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Details
Link-It Detail - Jax Mouse Phenotype - abnormal podocyte motility
Debug Stats
  • ### Total Build Time: 11 ms 7.716 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 380 bytes
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Jax Mouse Phenotype (1)
abnormal podocyte motility MP:0011865
Definition (1)
any anomaly in the ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM); motility refers to the dynamic reorganization of the interdigitating FP structure in vivo , and to the cell migration of cultured podocytes in vitro that is seen as surrogate for the former; alterations in podocyte motility are considered to underlie foot process effacement, with changes in the leading edge of the cell and its interactions with the GBM; a rather stationary podocyte phenotype is believed to reflect a stable FP structure with intact slit diaphragms, whereas hypermotility is believed to promote the development of FP effacement and proteinuria
Synonyms (1)
"abnormal podocyte foot process motility" NARROW
Parents (2)
img abnormal podocyte physiology MP:0011863
img abnormal cell migration MP:0003091
Children (2)
img increased podocyte motility MP:0011866
img decreased podocyte motility MP:0011867
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img renal/urinary system phenotype MP:00053676img abnormal podocyte physiology MP:0011863
img mammalian phenotype MP:0000001img cellular phenotype MP:00053845img abnormal cell migration MP:0003091
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0011865abnormal podocyte motility0self