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Details
Link-It Detail - Jax Mouse Phenotype - decreased solitary pulmonary neuroendocrine cell number
Debug Stats
  • ### Total Build Time: 11 ms 10.427 KB
  • CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 438 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.192 KB
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Jax Mouse Phenotype (1)
decreased solitary pulmonary neuroendocrine cell number MP:0010916
Definition (1)
decreased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis
Synonyms (1)
"reduced respiratory enterochromaffin cell number" EXACT
Parents (1)
img abnormal solitary pulmonary neuroendocrine cell morphology MP:0010914
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img nervous system phenotype MP:00036317img abnormal solitary pulmonary neuroendocrine cell morphology MP:0010914
img mammalian phenotype MP:0000001img endocrine/exocrine gland phenotype MP:00053797img abnormal solitary pulmonary neuroendocrine cell morphology MP:0010914
Genes (2)

Species:
human : 2
SpeciesGeneGeneIdGene NameEvidence
HumanNEUROD14760neuronal differentiation 1
img Jax MP, Pubmed Id: 10952889, MOUSE PHENOTYPE ID: MGI:96919
img Jax MP, Pubmed Id: 18339630, MOUSE PHENOTYPE ID: MGI:1339708
HumanASCL1429achaete-scute complex homolog 1 (Drosophila)
img Jax MP, Pubmed Id: 18339630, MOUSE PHENOTYPE ID: MGI:1339708
img Jax MP, Pubmed Id: 10952889, MOUSE PHENOTYPE ID: MGI:96919
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0010916decreased solitary pulmonary neuroendocrine cell number0self