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Details
Link-It Detail - Jax Mouse Phenotype - chromosomal instability
Debug Stats
  • ### Total Build Time: 376 ms 20.879 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 374 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 179 bytes
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  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
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  • CONCEPT_PARENTS gt=9 ms Completed: 9 ms rowSize= 584 bytes
  • CONCEPT_CHILDREN gt=10 ms Completed: 10 ms rowSize= 576 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=8 ms Completed: 8 ms rowSize= 1.569 KB
  • CONCEPT_RELATIONSHIPS gt=2 ms Completed: 2 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=338 ms Completed: 338 ms rowSize= 15.854 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.161 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
chromosomal instability MP:0008866
Definition (1)
abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity
Synonyms (1)
"genomic instability" RELATED
Parents (1)
img abnormal chromosome stability MP:0010094
Children (1)
img chromosome breakage MP:0004028
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img cellular phenotype MP:00053845img abnormal chromosome stability MP:0010094
Genes (85)

Species:
human : 85
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Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanMCM9254394minichromosome maintenance complex component 9
INFERRED
HumanNEK7140609NIMA-related kinase 7
Click here to display 101 evidence detail records.
HumanASZ1136991ankyrin repeat, SAM and basic leucine zipper domain containing 1
Click here to display 101 evidence detail records.
HumanMCM884515minichromosome maintenance complex component 8
INFERRED
HumanSLX484464SLX4 structure-specific endonuclease subunit
Click here to display 101 evidence detail records.
HumanUSP4484101ubiquitin specific peptidase 44
Click here to display 101 evidence detail records.
HumanMUS8180198MUS81 structure-specific endonuclease subunit
INFERRED
HumanCTC180169CTS telomere maintenance complex component 1
Click here to display 101 evidence detail records.
HumanATAD579915ATPase family, AAA domain containing 5
Click here to display 101 evidence detail records.
HumanNHEJ179840nonhomologous end-joining factor 1
INFERRED
HumanMCPH179648microcephalin 1
INFERRED
HumanRNASEH2B79621ribonuclease H2, subunit B
Click here to display 101 evidence detail records.
HumanNABP279035nucleic acid binding protein 2
Click here to display 101 evidence detail records.
HumanDCLRE1C64421DNA cross-link repair 1C
Click here to display 101 evidence detail records.
HumanAICDA57379activation-induced cytidine deaminase
Click here to display 101 evidence detail records.
HumanCHFR55743checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
INFERRED
HumanPINX154984PIN2/TERF1 interacting, telomerase inhibitor 1
Click here to display 101 evidence detail records.
HumanUIMC151720ubiquitin interaction motif containing 1
INFERRED
HumanSIRT651548sirtuin 6
INFERRED
HumanLATS226524large tumor suppressor kinase 2
INFERRED
HumanPOT125913protection of telomeres 1
INFERRED
HumanCOPS510987COP9 signalosome subunit 5
INFERRED
HumanPOLQ10721polymerase (DNA directed), theta
INFERRED
HumanRAD5010111RAD50 homolog (S. cerevisiae)
INFERRED
HumanPARP210038poly (ADP-ribose) polymerase 2
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008866chromosomal instability0self