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Details
Link-It Detail - Jax Mouse Phenotype - increased circulating interleukin-1 beta level
Debug Stats
  • ### Total Build Time: 155 ms 21.720 KB
  • CONCEPT_NAME gt=8 ms Completed: 8 ms rowSize= 420 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 458 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 195 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=8 ms Completed: 8 ms rowSize= 600 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=9 ms Completed: 9 ms rowSize= 4.322 KB
  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=115 ms Completed: 115 ms rowSize= 14.428 KB
  • CONCEPT_XREFS gt=13 ms Completed: 13 ms rowSize= 1.184 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
increased circulating interleukin-1 beta level MP:0008641
Definition (1)
increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane
Synonyms (1)
"increased circulating catabloin level" EXACT
Parents (1)
img abnormal circulating interleukin-1 beta level MP:0008640
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:000537610img abnormal circulating interleukin-1 beta level MP:0008640
img mammalian phenotype MP:0000001img immune system phenotype MP:000538710img abnormal circulating interleukin-1 beta level MP:0008640
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:000537611img abnormal circulating interleukin-1 beta level MP:0008640
Genes (24)

Species:
human : 24
SpeciesGeneGeneIdGene NameEvidence
HumanNLRP3114548NLR family, pyrin domain containing 3
Click here to display 34 evidence detail records.
HumanTNFAIP8L279626tumor necrosis factor, alpha-induced protein 8-like 2
Click here to display 34 evidence detail records.
HumanTBK129110TANK-binding kinase 1
Click here to display 34 evidence detail records.
HumanIL27RA9466interleukin 27 receptor, alpha
Click here to display 34 evidence detail records.
HumanSOCS28835suppressor of cytokine signaling 2
Click here to display 34 evidence detail records.
HumanSTX118676syntaxin 11
Click here to display 34 evidence detail records.
HumanNCOA38202nuclear receptor coactivator 3
Click here to display 34 evidence detail records.
HumanTHBD7056thrombomodulin
Click here to display 34 evidence detail records.
HumanBRD26046bromodomain containing 2
Click here to display 34 evidence detail records.
HumanRAB27A5873RAB27A, member RAS oncogene family
Click here to display 34 evidence detail records.
HumanPTPN65777protein tyrosine phosphatase, non-receptor type 6
Click here to display 34 evidence detail records.
HumanPRF15551perforin 1 (pore forming protein)
Click here to display 34 evidence detail records.
HumanPCSK15122proprotein convertase subtilisin/kexin type 1
Click here to display 34 evidence detail records.
HumanNFE2L24780nuclear factor, erythroid 2-like 2
Click here to display 34 evidence detail records.
HumanMEP1A4224meprin A, alpha (PABA peptide hydrolase)
Click here to display 34 evidence detail records.
HumanMEFV4210Mediterranean fever
Click here to display 34 evidence detail records.
HumanLIF3976leukemia inhibitory factor
Click here to display 34 evidence detail records.
HumanLDLR3949low density lipoprotein receptor
Click here to display 34 evidence detail records.
HumanIL10RA3587interleukin 10 receptor, alpha
Click here to display 34 evidence detail records.
HumanIL1R13554interleukin 1 receptor, type I
Click here to display 34 evidence detail records.
HumanELAVL11994ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
Click here to display 34 evidence detail records.
HumanCTSE1510cathepsin E
Click here to display 34 evidence detail records.
HumanCRY11407cryptochrome 1 (photolyase-like)
Click here to display 34 evidence detail records.
HumanC3AR1719complement component 3a receptor 1
Click here to display 34 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008641increased circulating interleukin-1 beta level0self