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Details
Link-It Detail - Jax Mouse Phenotype - abnormal circulating interleukin-18 level
Debug Stats
  • ### Total Build Time: 15 ms 15.582 KB
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Jax Mouse Phenotype (1)
abnormal circulating interleukin-18 level MP:0008634
Definition (1)
anomaly in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity
Synonyms (1)
"abnormal circulating interferon-gamma inducing factor" EXACT
Parents (1)
img abnormal circulating interleukin level MP:0008588
Children (2)
img increased circulating interleukin-18 level MP:0008635
img decreased circulating interleukin-18 level MP:0008636
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053768img abnormal circulating interleukin level MP:0008588
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal circulating interleukin level MP:0008588
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053769img abnormal circulating interleukin level MP:0008588
Genes (15)

Species:
human : 15
SpeciesGeneGeneIdGene NameEvidence
HumanCASP12100506742caspase 12 (gene/pseudogene)
INFERRED
HumanNLRP6171389NLR family, pyrin domain containing 6
INFERRED
HumanGBP5115362guanylate binding protein 5
INFERRED
HumanNLRP3114548NLR family, pyrin domain containing 3
INFERRED
HumanPYCARD29108PYD and CARD domain containing
INFERRED
HumanNLRP122861NLR family, pyrin domain containing 1
INFERRED
HumanAIM29447absent in melanoma 2
INFERRED
HumanPRF15551perforin 1 (pore forming protein)
INFERRED
HumanIL183606interleukin 18 (interferon-gamma-inducing factor)
INFERRED
HumanIL1R13554interleukin 1 receptor, type I
INFERRED
HumanIFNAR13454interferon (alpha, beta and omega) receptor 1
INFERRED
HumanF2RL12150coagulation factor II (thrombin) receptor-like 1
INFERRED
HumanDNASE21777deoxyribonuclease II, lysosomal
INFERRED
HumanCTSE1510cathepsin E
INFERRED
HumanCASP4837caspase 4, apoptosis-related cysteine peptidase
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008634abnormal circulating interleukin-18 level0self