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Details
Link-It Detail - Jax Mouse Phenotype - abnormal circulating interleukin-4 level
Debug Stats
  • ### Total Build Time: 36 ms 22.622 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 408 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 450 bytes
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  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
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  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=25 ms Completed: 25 ms rowSize= 14.331 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.178 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
abnormal circulating interleukin-4 level MP:0008601
Definition (1)
anomaly in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells
Synonyms (1)
"abnormal circulating B-cell growth factor-1 level" EXACT
Parents (1)
img abnormal circulating interleukin level MP:0008588
Children (2)
img decreased circulating interleukin-4 level MP:0008603
img increased circulating interleukin-4 level MP:0008602
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal circulating interleukin level MP:0008588
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053769img abnormal circulating interleukin level MP:0008588
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053768img abnormal circulating interleukin level MP:0008588
Genes (24)

Species:
human : 24
SpeciesGeneGeneIdGene NameEvidence
HumanGIMAP1-GIMAP5100527949
INFERRED
HumanTSLP85480thymic stromal lymphopoietin
INFERRED
HumanNFATC2IP84901nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
INFERRED
HumanCARD1184433caspase recruitment domain family, member 11
INFERRED
HumanCXCL1658191chemokine (C-X-C motif) ligand 16
INFERRED
HumanFOXP350943forkhead box P3
INFERRED
HumanICOS29851inducible T-cell co-stimulator
INFERRED
HumanEBI310148Epstein-Barr virus induced 3
INFERRED
HumanIL27RA9466interleukin 27 receptor, alpha
INFERRED
HumanMTA29219metastasis associated 1 family, member 2
INFERRED
HumanMAP3K149020mitogen-activated protein kinase kinase kinase 14
INFERRED
HumanSTAT66778signal transducer and activator of transcription 6, interleukin-4 induced
img Jax MP, Pubmed Id: 12807824, MOUSE PHENOTYPE ID: MGI:96590
img Jax MP, Pubmed Id: 9500796, MOUSE PHENOTYPE ID: MGI:103034
HumanRELB5971v-rel avian reticuloendotheliosis viral oncogene homolog B
INFERRED
HumanPPIA5478peptidylprolyl isomerase A (cyclophilin A)
INFERRED
HumanIRF13659interferon regulatory factor 1
img Jax MP, Pubmed Id: 9500796, MOUSE PHENOTYPE ID: MGI:103034
img Jax MP, Pubmed Id: 12807824, MOUSE PHENOTYPE ID: MGI:96590
HumanIL4R3566interleukin 4 receptor
INFERRED
HumanIL23558interleukin 2
INFERRED
HumanHEXB3074hexosaminidase B (beta polypeptide)
INFERRED
HumanGNAI22771guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
INFERRED
HumanGATA12623GATA binding protein 1 (globin transcription factor 1)
INFERRED
HumanFCER1A2205Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
INFERRED
HumanCCR31232chemokine (C-C motif) receptor 3
INFERRED
HumanCD28940CD28 molecule
INFERRED
HumanCD19930CD19 molecule
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008601abnormal circulating interleukin-4 level0self