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Details
Link-It Detail - Jax Mouse Phenotype - decreased tumor necrosis factor secretion
Debug Stats
  • ### Total Build Time: 429 ms 22.241 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 410 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 513 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 595 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=4 ms Completed: 4 ms rowSize= 1.585 KB
  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=420 ms Completed: 420 ms rowSize= 17.660 KB
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.179 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
decreased tumor necrosis factor secretion MP:0008561
Definition (1)
reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Synonyms (1)
"decreased cachectin secretion" EXACT
Parents (1)
img abnormal tumor necrosis factor secretion MP:0008556
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal tumor necrosis factor secretion MP:0008556
Genes (93)

Species:
human : 93
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SpeciesGeneGeneIdGene NameEvidence
HumanGIMAP1-GIMAP5100527949
Click here to display 160 evidence detail records.
HumanTICAM1148022toll-like receptor adaptor molecule 1
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HumanSLC15A4121260solute carrier family 15 (oligopeptide transporter), member 4
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HumanCLEC6A93978C-type lectin domain family 6, member A
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HumanTIMD491937T-cell immunoglobulin and mucin domain containing 4
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HumanUNC93B181622unc-93 homolog B1 (C. elegans)
Click here to display 160 evidence detail records.
HumanRHBDF279651rhomboid 5 homolog 2 (Drosophila)
Click here to display 160 evidence detail records.
HumanDHX5879132DEXH (Asp-Glu-X-His) box polypeptide 58
Click here to display 160 evidence detail records.
HumanCARD964170caspase recruitment domain family, member 9
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HumanNOD264127nucleotide-binding oligomerization domain containing 2
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HumanSELK58515selenoprotein K
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HumanCCAR257805cell cycle and apoptosis regulator 2
Click here to display 160 evidence detail records.
HumanMAVS57506mitochondrial antiviral signaling protein
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HumanPELI157162pellino E3 ubiquitin protein ligase 1
Click here to display 160 evidence detail records.
HumanMARCH155016membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Click here to display 160 evidence detail records.
HumanTOLLIP54472toll interacting protein
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HumanSASH354440SAM and SH3 domain containing 3
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HumanTLR954106toll-like receptor 9
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HumanIRAK451135interleukin-1 receptor-associated kinase 4
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HumanPILRB29990paired immunoglobin-like type 2 receptor beta
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HumanPYCARD29108PYD and CARD domain containing
Click here to display 160 evidence detail records.
HumanCLEC4E26253C-type lectin domain family 4, member E
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HumanCLIC425932chloride intracellular channel 4
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HumanLY9623643lymphocyte antigen 96
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HumanCORO1A11151coronin, actin binding protein, 1A
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XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008561decreased tumor necrosis factor secretion0self