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Details
Link-It Detail - Jax Mouse Phenotype - increased circulating tumor necrosis factor level
Debug Stats
  • ### Total Build Time: 530 ms 24.768 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 426 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 502 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 195 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=10 ms Completed: 10 ms rowSize= 603 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=10 ms Completed: 10 ms rowSize= 4.328 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=498 ms Completed: 498 ms rowSize= 17.415 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.187 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
increased circulating tumor necrosis factor level MP:0008553
Definition (1)
greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Synonyms (1)
"increased circulating cachectin level" EXACT
Parents (1)
img abnormal circulating tumor necrosis factor level MP:0008552
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053768img abnormal circulating tumor necrosis factor level MP:0008552
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal circulating tumor necrosis factor level MP:0008552
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053769img abnormal circulating tumor necrosis factor level MP:0008552
Genes (67)

Species:
human : 67
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SpeciesGeneGeneIdGene NameEvidence
HumanNLRC3197358NLR family, CARD domain containing 3
Click here to display 102 evidence detail records.
HumanSLAMF6114836SLAM family member 6
Click here to display 102 evidence detail records.
HumanNLRP3114548NLR family, pyrin domain containing 3
Click here to display 102 evidence detail records.
HumanUNC93B181622unc-93 homolog B1 (C. elegans)
Click here to display 102 evidence detail records.
HumanZC3H12A80149zinc finger CCCH-type containing 12A
Click here to display 102 evidence detail records.
HumanTNFAIP8L279626tumor necrosis factor, alpha-induced protein 8-like 2
Click here to display 102 evidence detail records.
HumanNOD264127nucleotide-binding oligomerization domain containing 2
Click here to display 102 evidence detail records.
HumanMAVS57506mitochondrial antiviral signaling protein
Click here to display 102 evidence detail records.
HumanTBC1D2355773TBC1 domain family, member 23
Click here to display 102 evidence detail records.
HumanTREM154210triggering receptor expressed on myeloid cells 1
Click here to display 102 evidence detail records.
HumanFOXP350943forkhead box P3
Click here to display 102 evidence detail records.
HumanTBK129110TANK-binding kinase 1
Click here to display 102 evidence detail records.
HumanRPL13A23521ribosomal protein L13a
Click here to display 102 evidence detail records.
HumanSIRT323410sirtuin 3
Click here to display 102 evidence detail records.
HumanMERTK10461c-mer proto-oncogene tyrosine kinase
Click here to display 102 evidence detail records.
HumanCLEC4M10332C-type lectin domain family 4, member M
Click here to display 102 evidence detail records.
HumanRAMP110267receptor (G protein-coupled) activity modifying protein 1
Click here to display 102 evidence detail records.
HumanIL27RA9466interleukin 27 receptor, alpha
Click here to display 102 evidence detail records.
HumanRPS6KA59252ribosomal protein S6 kinase, 90kDa, polypeptide 5
Click here to display 102 evidence detail records.
HumanSTX118676syntaxin 11
Click here to display 102 evidence detail records.
HumanIKBKG8517inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Click here to display 102 evidence detail records.
HumanPARG8505poly (ADP-ribose) glycohydrolase
Click here to display 102 evidence detail records.
HumanNCOA38202nuclear receptor coactivator 3
Click here to display 102 evidence detail records.
HumanLAT27462linker for activation of T cells family, member 2
Click here to display 102 evidence detail records.
HumanTYRO37301TYRO3 protein tyrosine kinase
Click here to display 102 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008553increased circulating tumor necrosis factor level0self