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Details
Link-It Detail - Jax Mouse Phenotype - abnormal circulating tumor necrosis factor level
Debug Stats
  • ### Total Build Time: 64 ms 26.308 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 424 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 194 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
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  • CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 1.038 KB
  • CONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 1.066 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=3 ms Completed: 3 ms rowSize= 6.993 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=48 ms Completed: 48 ms rowSize= 14.779 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.186 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
abnormal circulating tumor necrosis factor level MP:0008552
Definition (1)
anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
Synonyms (1)
"abnormal circulating cachectin level" EXACT
Parents (2)
img abnormal tumor necrosis factor level MP:0008752
img abnormal circulating cytokine level MP:0010210
Children (2)
img increased circulating tumor necrosis factor level MP:0008553
img decreased circulating tumor necrosis factor level MP:0008554
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal tumor necrosis factor level MP:0008752
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053768img abnormal tumor necrosis factor level MP:0008752
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053767img abnormal circulating cytokine level MP:0010210
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal circulating cytokine level MP:0010210
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053768img abnormal circulating cytokine level MP:0010210
Genes (103)

Species:
human : 103
Page Size
Current 25
  Page 1 of 5
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanNLRC3197358NLR family, CARD domain containing 3
INFERRED
HumanBBS12166379Bardet-Biedl syndrome 12
INFERRED
HumanTICAM1148022toll-like receptor adaptor molecule 1
Click here to display 6 evidence detail records.
HumanSLAMF6114836SLAM family member 6
INFERRED
HumanNLRP3114548NLR family, pyrin domain containing 3
INFERRED
HumanUNC93B181622unc-93 homolog B1 (C. elegans)
INFERRED
HumanZC3H12A80149zinc finger CCCH-type containing 12A
INFERRED
HumanRHBDF279651rhomboid 5 homolog 2 (Drosophila)
INFERRED
HumanTNFAIP8L279626tumor necrosis factor, alpha-induced protein 8-like 2
INFERRED
HumanNOD264127nucleotide-binding oligomerization domain containing 2
INFERRED
HumanMAVS57506mitochondrial antiviral signaling protein
INFERRED
HumanPELI157162pellino E3 ubiquitin protein ligase 1
INFERRED
HumanTBC1D2355773TBC1 domain family, member 23
INFERRED
HumanTREM154210triggering receptor expressed on myeloid cells 1
INFERRED
HumanIRAK451135interleukin-1 receptor-associated kinase 4
INFERRED
HumanFOXP350943forkhead box P3
INFERRED
HumanIL2250616interleukin 22
INFERRED
HumanPILRB29990paired immunoglobin-like type 2 receptor beta
INFERRED
HumanTBK129110TANK-binding kinase 1
INFERRED
HumanCLIC425932chloride intracellular channel 4
INFERRED
HumanRPL13A23521ribosomal protein L13a
INFERRED
HumanSIRT323410sirtuin 3
INFERRED
HumanMERTK10461c-mer proto-oncogene tyrosine kinase
INFERRED
HumanCLEC4M10332C-type lectin domain family 4, member M
INFERRED
HumanRAMP110267receptor (G protein-coupled) activity modifying protein 1
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008552abnormal circulating tumor necrosis factor level0self