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Details
Link-It Detail - Jax Mouse Phenotype - abnormal circulating interferon level
Debug Stats
  • ### Total Build Time: 50 ms 37.053 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 402 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 567 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 188 bytes
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  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 1.027 KB
  • CONCEPT_CHILDREN gt=4 ms Completed: 4 ms rowSize= 1.523 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=1 ms Completed: 1 ms rowSize= 6.972 KB
  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=40 ms Completed: 40 ms rowSize= 25.081 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.175 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
abnormal circulating interferon level MP:0008548
Definition (1)
anomaly in the amount in the blood of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions
Synonyms (1)
"abnormal circulating IFN level" EXACT
Parents (2)
img abnormal circulating cytokine level MP:0010210
img abnormal interferon level MP:0008750
Children (3)
img abnormal circulating interferon-gamma level MP:0008551
img abnormal circulating interferon-alpha level MP:0008549
img abnormal circulating interferon-beta level MP:0008550
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053767img abnormal circulating cytokine level MP:0010210
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal circulating cytokine level MP:0010210
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053768img abnormal circulating cytokine level MP:0010210
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal interferon level MP:0008750
img mammalian phenotype MP:0000001img homeostasis/metabolism phenotype MP:00053768img abnormal interferon level MP:0008750
Genes (74)

Species:
human : 74
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Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanGIMAP1-GIMAP5100527949
INFERRED
HumanIRGM345611immunity-related GTPase family, M
INFERRED
HumanTMEM173340061transmembrane protein 173
INFERRED
HumanTICAM1148022toll-like receptor adaptor molecule 1
INFERRED
HumanRSAD291543radical S-adenosyl methionine domain containing 2
INFERRED
HumanBCL2L1283596BCL2-like 12 (proline rich)
img Jax MP, Pubmed Id: 11070172, MOUSE PHENOTYPE ID: MGI:1922986
img Jax MP, Pubmed Id: 20140199, MOUSE PHENOTYPE ID: MGI:2444773
img Jax MP, Pubmed Id: 23416614, MOUSE PHENOTYPE ID: MGI:2180849
img Jax MP, Pubmed Id: 11070172, MOUSE PHENOTYPE ID: MGI:1859179
img Jax MP, Pubmed Id: 16415873, MOUSE PHENOTYPE ID: MGI:1859307
HumanUNC93B181622unc-93 homolog B1 (C. elegans)
img Jax MP, Pubmed Id: 23416614, MOUSE PHENOTYPE ID: MGI:2180849
img Jax MP, Pubmed Id: 16415873, MOUSE PHENOTYPE ID: MGI:1859307
img Jax MP, Pubmed Id: 20140199, MOUSE PHENOTYPE ID: MGI:2444773
img Jax MP, Pubmed Id: 11070172, MOUSE PHENOTYPE ID: MGI:1859179
img Jax MP, Pubmed Id: 11070172, MOUSE PHENOTYPE ID: MGI:1922986
HumanDHX5879132DEXH (Asp-Glu-X-His) box polypeptide 58
INFERRED
HumanNOD264127nucleotide-binding oligomerization domain containing 2
INFERRED
HumanSAMSN164092SAM domain, SH3 domain and nuclear localization signals 1
INFERRED
HumanCXCL1658191chemokine (C-X-C motif) ligand 16
INFERRED
HumanMAVS57506mitochondrial antiviral signaling protein
img Jax MP, Pubmed Id: 20140199, MOUSE PHENOTYPE ID: MGI:2444773
img Jax MP, Pubmed Id: 11070172, MOUSE PHENOTYPE ID: MGI:1859179
img Jax MP, Pubmed Id: 23416614, MOUSE PHENOTYPE ID: MGI:2180849
img Jax MP, Pubmed Id: 16415873, MOUSE PHENOTYPE ID: MGI:1859307
img Jax MP, Pubmed Id: 11070172, MOUSE PHENOTYPE ID: MGI:1922986
HumanPELI157162pellino E3 ubiquitin protein ligase 1
INFERRED
HumanTLR954106toll-like receptor 9
INFERRED
HumanTLR751284toll-like receptor 7
INFERRED
HumanIRAK451135interleukin-1 receptor-associated kinase 4
INFERRED
HumanFOXP350943forkhead box P3
INFERRED
HumanPACSIN129993protein kinase C and casein kinase substrate in neurons 1
INFERRED
HumanPILRB29990paired immunoglobin-like type 2 receptor beta
INFERRED
HumanICOS29851inducible T-cell co-stimulator
INFERRED
HumanSIRT323410sirtuin 3
INFERRED
HumanUSP1811274ubiquitin specific peptidase 18
INFERRED
HumanRAMP110267receptor (G protein-coupled) activity modifying protein 1
INFERRED
HumanEBI310148Epstein-Barr virus induced 3
INFERRED
HumanIL27RA9466interleukin 27 receptor, alpha
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008548abnormal circulating interferon level0self