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Details
Link-It Detail - Jax Mouse Phenotype - abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology
Debug Stats
  • ### Total Build Time: 45 ms 33.093 KB
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  • CONCEPT_XREFS gt=9 ms Completed: 9 ms rowSize= 1.214 KB
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Jax Mouse Phenotype (1)
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology MP:0008397
Definition (1)
any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release
Synonyms (1)
"abnormal suppressor T-cell morphology" BROAD
Parents (2)
img abnormal regulatory T cell morphology MP:0004941
img abnormal CD4-positive T cell morphology MP:0002432
Children (2)
img decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number MP:0010169
img increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number MP:0010168
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:000538710img abnormal regulatory T cell morphology MP:0004941
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539711img abnormal regulatory T cell morphology MP:0004941
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539710img abnormal regulatory T cell morphology MP:0004941
img mammalian phenotype MP:0000001img immune system phenotype MP:000538711img abnormal CD4-positive T cell morphology MP:0002432
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539712img abnormal CD4-positive T cell morphology MP:0002432
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539711img abnormal CD4-positive T cell morphology MP:0002432
Genes (9)

Species:
human : 9
SpeciesGeneGeneIdGene NameEvidence
HumanCARD1184433caspase recruitment domain family, member 11
img Jax MP, Pubmed Id: 12612578, MOUSE PHENOTYPE ID: MGI:1891436
img Jax MP, Pubmed Id: 19260764, MOUSE PHENOTYPE ID: MGI:1916978
img Jax MP, Pubmed Id: 14764671
img Jax MP, Pubmed Id: 16709807, MOUSE PHENOTYPE ID: MGI:103070
img Jax MP, Pubmed Id: 17060023
img Jax MP, Pubmed Id: 18195075, MOUSE PHENOTYPE ID: MGI:2181659
HumanGMNN51053geminin, DNA replication inhibitor
INFERRED
HumanFOXP350943forkhead box P3
img Jax MP, Pubmed Id: 16709807, MOUSE PHENOTYPE ID: MGI:103070
img Jax MP, Pubmed Id: 14764671
img Jax MP, Pubmed Id: 19260764, MOUSE PHENOTYPE ID: MGI:1916978
img Jax MP, Pubmed Id: 12612578, MOUSE PHENOTYPE ID: MGI:1891436
img Jax MP, Pubmed Id: 17060023
img Jax MP, Pubmed Id: 18195075, MOUSE PHENOTYPE ID: MGI:2181659
HumanBATF10538basic leucine zipper transcription factor, ATF-like
INFERRED
HumanTOX9760thymocyte selection-associated high mobility group box
img Jax MP, Pubmed Id: 18195075, MOUSE PHENOTYPE ID: MGI:2181659
img Jax MP, Pubmed Id: 17060023
img Jax MP, Pubmed Id: 14764671
img Jax MP, Pubmed Id: 16709807, MOUSE PHENOTYPE ID: MGI:103070
img Jax MP, Pubmed Id: 12612578, MOUSE PHENOTYPE ID: MGI:1891436
img Jax MP, Pubmed Id: 19260764, MOUSE PHENOTYPE ID: MGI:1916978
HumanSTAT5B6777signal transducer and activator of transcription 5B
INFERRED
HumanLAIR13903leukocyte-associated immunoglobulin-like receptor 1
INFERRED
HumanIL23558interleukin 2
INFERRED
HumanHLA-DQB13119
img Jax MP, Pubmed Id: 14764671
img Jax MP, Pubmed Id: 12612578, MOUSE PHENOTYPE ID: MGI:1891436
img Jax MP, Pubmed Id: 17060023
img Jax MP, Pubmed Id: 18195075, MOUSE PHENOTYPE ID: MGI:2181659
img Jax MP, Pubmed Id: 16709807, MOUSE PHENOTYPE ID: MGI:103070
img Jax MP, Pubmed Id: 19260764, MOUSE PHENOTYPE ID: MGI:1916978
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008397abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology0self