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Details
Link-It Detail - Jax Mouse Phenotype - absent B-1 B cells
Debug Stats
  • ### Total Build Time: 74 ms 35.911 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 364 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 585 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=23 ms Completed: 23 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 1.016 KB
  • CONCEPT_CHILDREN gt=4 ms Completed: 4 ms rowSize= 1.004 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=5 ms Completed: 5 ms rowSize= 17.649 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=27 ms Completed: 27 ms rowSize= 14.015 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.156 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
absent B-1 B cells MP:0008202
Definition (1)
absence of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas
Parents (2)
img absent mature B cells MP:0008212
img decreased B-1 B cell number MP:0004978
Children (2)
img absent B-1b cells MP:0008204
img absent B-1a cells MP:0008203
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539713img absent mature B cells MP:0008212
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539712img absent mature B cells MP:0008212
img mammalian phenotype MP:0000001img immune system phenotype MP:000538712img absent mature B cells MP:0008212
img mammalian phenotype MP:0000001img immune system phenotype MP:000538713img absent mature B cells MP:0008212
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539714img absent mature B cells MP:0008212
img mammalian phenotype MP:0000001img immune system phenotype MP:00053879img absent mature B cells MP:0008212
img mammalian phenotype MP:0000001img immune system phenotype MP:000538710img decreased B-1 B cell number MP:0004978
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539713img decreased B-1 B cell number MP:0004978
img mammalian phenotype MP:0000001img immune system phenotype MP:000538713img decreased B-1 B cell number MP:0004978
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539714img decreased B-1 B cell number MP:0004978
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539712img decreased B-1 B cell number MP:0004978
img mammalian phenotype MP:0000001img immune system phenotype MP:000538712img decreased B-1 B cell number MP:0004978
img mammalian phenotype MP:0000001img immune system phenotype MP:00053879img decreased B-1 B cell number MP:0004978
Genes (10)

Species:
human : 10
SpeciesGeneGeneIdGene NameEvidence
HumanPIK3AP1118788phosphoinositide-3-kinase adaptor protein 1
INFERRED
HumanCARD1184433caspase recruitment domain family, member 11
INFERRED
HumanBLNK29760B-cell linker
INFERRED
HumanMALT110892mucosa associated lymphoid tissue lymphoma translocation gene 1
INFERRED
HumanIKZF110320IKAROS family zinc finger 1 (Ikaros)
INFERRED
HumanPIK3CD5293phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
img Jax MP, Pubmed Id: 12538695, MOUSE PHENOTYPE ID: MGI:96495
img Jax MP, Pubmed Id: 7542362, MOUSE PHENOTYPE ID: MGI:95275
img Jax MP, Pubmed Id: 14758357, MOUSE PHENOTYPE ID: MGI:96442
img Jax MP, Pubmed Id: 9586639, MOUSE PHENOTYPE ID: MGI:3053738
img Jax MP, Pubmed Id: 12538695, MOUSE PHENOTYPE ID: MGI:96495
img Jax MP, Pubmed Id: 12446777, MOUSE PHENOTYPE ID: MGI:1098211
HumanETS12113v-ets avian erythroblastosis virus E26 oncogene homolog 1
INFERRED
HumanEBF11879early B-cell factor 1
img Jax MP, Pubmed Id: 12446777, MOUSE PHENOTYPE ID: MGI:1098211
img Jax MP, Pubmed Id: 12538695, MOUSE PHENOTYPE ID: MGI:96495
img Jax MP, Pubmed Id: 14758357, MOUSE PHENOTYPE ID: MGI:96442
img Jax MP, Pubmed Id: 9586639, MOUSE PHENOTYPE ID: MGI:3053738
img Jax MP, Pubmed Id: 12538695, MOUSE PHENOTYPE ID: MGI:96495
img Jax MP, Pubmed Id: 7542362, MOUSE PHENOTYPE ID: MGI:95275
HumanCD79A973CD79a molecule, immunoglobulin-associated alpha
INFERRED
HumanBTK695Bruton agammaglobulinemia tyrosine kinase
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008202absent B-1 B cells0self