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Details
Link-It Detail - Jax Mouse Phenotype - decreased Langerhans cell number
Debug Stats
  • ### Total Build Time: 15 ms 90.928 KB
  • CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 392 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 572 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 194 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 1.041 KB
  • CONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 579 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 19.174 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=10 ms Completed: 10 ms rowSize= 67.702 KB
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.170 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
decreased Langerhans cell number MP:0008119
Definition (1)
reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus
Synonyms (1)
"decreased number of Langerhans cells" EXACT
Parents (2)
img abnormal Langerhans cell morphology MP:0008117
img decreased myeloid dendritic cell number MP:0008122
Children (1)
img absent Langerhans cell MP:0008118
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053879img abnormal Langerhans cell morphology MP:0008117
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539710img abnormal Langerhans cell morphology MP:0008117
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:00053979img abnormal Langerhans cell morphology MP:0008117
img mammalian phenotype MP:0000001img immune system phenotype MP:000538710img abnormal Langerhans cell morphology MP:0008117
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539711img abnormal Langerhans cell morphology MP:0008117
img mammalian phenotype MP:0000001img immune system phenotype MP:000538711img abnormal Langerhans cell morphology MP:0008117
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539712img abnormal Langerhans cell morphology MP:0008117
img mammalian phenotype MP:0000001img immune system phenotype MP:000538710img decreased myeloid dendritic cell number MP:0008122
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539711img decreased myeloid dendritic cell number MP:0008122
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539710img decreased myeloid dendritic cell number MP:0008122
img mammalian phenotype MP:0000001img immune system phenotype MP:000538711img decreased myeloid dendritic cell number MP:0008122
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539712img decreased myeloid dendritic cell number MP:0008122
img mammalian phenotype MP:0000001img immune system phenotype MP:000538712img decreased myeloid dendritic cell number MP:0008122
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539713img decreased myeloid dendritic cell number MP:0008122
Genes (10)

Species:
human : 10
SpeciesGeneGeneIdGene NameEvidence
HumanIL34146433interleukin 34
img Jax MP, Pubmed Id: 17638889, MOUSE PHENOTYPE ID: MGI:102768
img Jax MP, Pubmed Id: 17353357, MOUSE PHENOTYPE ID: MGI:96615
img Jax MP, Pubmed Id: 15057277, MOUSE PHENOTYPE ID: MGI:3802582
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 11756160, MOUSE PHENOTYPE ID: MGI:1339758
img Jax MP, Pubmed Id: 15894281, MOUSE PHENOTYPE ID: MGI:2180021
img Jax MP, Pubmed Id: 22729249, MOUSE PHENOTYPE ID: MGI:1923777
img Jax MP, Pubmed Id: 18606662, MOUSE PHENOTYPE ID: MGI:1100089
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
HumanB9D280776B9 protein domain 2
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 17353357, MOUSE PHENOTYPE ID: MGI:96615
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 15057277, MOUSE PHENOTYPE ID: MGI:3802582
img Jax MP, Pubmed Id: 15894281, MOUSE PHENOTYPE ID: MGI:2180021
img Jax MP, Pubmed Id: 22729249, MOUSE PHENOTYPE ID: MGI:1923777
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 11756160, MOUSE PHENOTYPE ID: MGI:1339758
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17638889, MOUSE PHENOTYPE ID: MGI:102768
img Jax MP, Pubmed Id: 18606662, MOUSE PHENOTYPE ID: MGI:1100089
HumanCD20750489CD207 molecule, langerin
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17638889, MOUSE PHENOTYPE ID: MGI:102768
img Jax MP, Pubmed Id: 11756160, MOUSE PHENOTYPE ID: MGI:1339758
img Jax MP, Pubmed Id: 15057277, MOUSE PHENOTYPE ID: MGI:3802582
img Jax MP, Pubmed Id: 15894281, MOUSE PHENOTYPE ID: MGI:2180021
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 18606662, MOUSE PHENOTYPE ID: MGI:1100089
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 17353357, MOUSE PHENOTYPE ID: MGI:96615
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 22729249, MOUSE PHENOTYPE ID: MGI:1923777
HumanTNFSF118600tumor necrosis factor (ligand) superfamily, member 11
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 22729249, MOUSE PHENOTYPE ID: MGI:1923777
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 18606662, MOUSE PHENOTYPE ID: MGI:1100089
img Jax MP, Pubmed Id: 11756160, MOUSE PHENOTYPE ID: MGI:1339758
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 15894281, MOUSE PHENOTYPE ID: MGI:2180021
img Jax MP, Pubmed Id: 15057277, MOUSE PHENOTYPE ID: MGI:3802582
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17353357, MOUSE PHENOTYPE ID: MGI:96615
img Jax MP, Pubmed Id: 17638889, MOUSE PHENOTYPE ID: MGI:102768
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
HumanTGFB17040transforming growth factor, beta 1
INFERRED
HumanMFGE84240milk fat globule-EGF factor 8 protein
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17353357, MOUSE PHENOTYPE ID: MGI:96615
img Jax MP, Pubmed Id: 11756160, MOUSE PHENOTYPE ID: MGI:1339758
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 22729249, MOUSE PHENOTYPE ID: MGI:1923777
img Jax MP, Pubmed Id: 17638889, MOUSE PHENOTYPE ID: MGI:102768
img Jax MP, Pubmed Id: 15894281, MOUSE PHENOTYPE ID: MGI:2180021
img Jax MP, Pubmed Id: 15057277, MOUSE PHENOTYPE ID: MGI:3802582
img Jax MP, Pubmed Id: 18606662, MOUSE PHENOTYPE ID: MGI:1100089
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
HumanITGB63694integrin, beta 6
img Jax MP, Pubmed Id: 15894281, MOUSE PHENOTYPE ID: MGI:2180021
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 11756160, MOUSE PHENOTYPE ID: MGI:1339758
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17638889, MOUSE PHENOTYPE ID: MGI:102768
img Jax MP, Pubmed Id: 15057277, MOUSE PHENOTYPE ID: MGI:3802582
img Jax MP, Pubmed Id: 18606662, MOUSE PHENOTYPE ID: MGI:1100089
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 22729249, MOUSE PHENOTYPE ID: MGI:1923777
img Jax MP, Pubmed Id: 17353357, MOUSE PHENOTYPE ID: MGI:96615
HumanCSF1R1436colony stimulating factor 1 receptor
img Jax MP, Pubmed Id: 15057277, MOUSE PHENOTYPE ID: MGI:3802582
img Jax MP, Pubmed Id: 18606662, MOUSE PHENOTYPE ID: MGI:1100089
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 15894281, MOUSE PHENOTYPE ID: MGI:2180021
img Jax MP, Pubmed Id: 22729249, MOUSE PHENOTYPE ID: MGI:1923777
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:2387643
img Jax MP, Pubmed Id: 11756160, MOUSE PHENOTYPE ID: MGI:1339758
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17638889, MOUSE PHENOTYPE ID: MGI:102768
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17938236, MOUSE PHENOTYPE ID: MGI:3761648
img Jax MP, Pubmed Id: 17353357, MOUSE PHENOTYPE ID: MGI:96615
HumanCSF11435colony stimulating factor 1 (macrophage)
INFERRED
HumanRUNX3864runt-related transcription factor 3
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008119decreased Langerhans cell number0self