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Details
Link-It Detail - Jax Mouse Phenotype - retinal ganglion cell degeneration
Debug Stats
  • ### Total Build Time: 25 ms 17.001 KB
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Jax Mouse Phenotype (1)
retinal ganglion cell degeneration MP:0008067
Definition (1)
degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain
Parents (2)
img neuron degeneration MP:0003224
img abnormal retinal ganglion cell morphology MP:0008056
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img nervous system phenotype MP:00036316img neuron degeneration MP:0003224
img mammalian phenotype MP:0000001img nervous system phenotype MP:00036317img abnormal retinal ganglion cell morphology MP:0008056
img mammalian phenotype MP:0000001img nervous system phenotype MP:00036318img abnormal retinal ganglion cell morphology MP:0008056
img mammalian phenotype MP:0000001img vision/eye phenotype MP:000539111img abnormal retinal ganglion cell morphology MP:0008056
Genes (13)

Species:
human : 13
SpeciesGeneGeneIdGene NameEvidence
HumanPRSS56646960protease, serine, 56
Click here to display 24 evidence detail records.
HumanMPP564398membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Click here to display 24 evidence detail records.
HumanLGR455366leucine-rich repeat containing G protein-coupled receptor 4
Click here to display 24 evidence detail records.
HumanTRIM223321tripartite motif containing 2
Click here to display 24 evidence detail records.
HumanGPNMB10457glycoprotein (transmembrane) nmb
Click here to display 24 evidence detail records.
HumanASIC39311acid-sensing (proton-gated) ion channel 3
Click here to display 24 evidence detail records.
HumanAIFM19131apoptosis-inducing factor, mitochondrion-associated, 1
Click here to display 24 evidence detail records.
HumanVAV27410vav 2 guanine nucleotide exchange factor
Click here to display 24 evidence detail records.
HumanPOU4F25458POU class 4 homeobox 2
Click here to display 24 evidence detail records.
HumanNTRK34916neurotrophic tyrosine kinase, receptor, type 3
Click here to display 24 evidence detail records.
HumanISL13670ISL LIM homeobox 1
Click here to display 24 evidence detail records.
HumanBCL2596B-cell CLL/lymphoma 2
Click here to display 24 evidence detail records.
HumanFASLG356Fas ligand (TNF superfamily, member 6)
Click here to display 24 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0008067retinal ganglion cell degeneration0self