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Details
Link-It Detail - Jax Mouse Phenotype - abnormal antigen presentation via MHC class II
Debug Stats
  • ### Total Build Time: 108 ms 20.900 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 420 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=1 ms Completed: 1 ms rowSize= 317 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=12 ms Completed: 12 ms rowSize= 1.038 KB
  • CONCEPT_CHILDREN gt=13 ms Completed: 13 ms rowSize= 1.053 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=34 ms Completed: 34 ms rowSize= 5.633 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=39 ms Completed: 39 ms rowSize= 11.129 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.184 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
abnormal antigen presentation via MHC class II MP:0005041
Definition (1)
anomaly in the process by which peptide, bound to major histocompatibility complex class II, is presented to lymphocytes at the surface of antigen presenting cells
Parents (2)
img abnormal antigen presentation MP:0001835
img abnormal B lymphocyte antigen presentation MP:0002453
Children (2)
img abnormal level of surface class II molecules MP:0005042
img defective assembly of class II molecules MP:0005043
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053875img abnormal antigen presentation MP:0001835
img mammalian phenotype MP:0000001img immune system phenotype MP:00053876img abnormal B lymphocyte antigen presentation MP:0002453
img mammalian phenotype MP:0000001img immune system phenotype MP:00053879img abnormal B lymphocyte antigen presentation MP:0002453
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal B lymphocyte antigen presentation MP:0002453
Genes (22)

Species:
human : 22
SpeciesGeneGeneIdGene NameEvidence
HumanTIRAP114609toll-interleukin 1 receptor (TIR) domain containing adaptor protein
INFERRED
HumanUNC93B181622unc-93 homolog B1 (C. elegans)
Click here to display 18 evidence detail records.
HumanMARCH155016membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
INFERRED
HumanTLR47099toll-like receptor 4
INFERRED
HumanSTAT66778signal transducer and activator of transcription 6, interleukin-4 induced
INFERRED
HumanSTAT26773signal transducer and activator of transcription 2, 113kDa
INFERRED
HumanSTAT16772signal transducer and activator of transcription 1, 91kDa
INFERRED
HumanRFX55993regulatory factor X, 5 (influences HLA class II expression)
INFERRED
HumanRAG15896recombination activating gene 1
INFERRED
HumanPRKDC5591protein kinase, DNA-activated, catalytic polypeptide
INFERRED
HumanPRF15551perforin 1 (pore forming protein)
INFERRED
HumanCIITA4261class II, major histocompatibility complex, transactivator
INFERRED
HumanLYN4067v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
INFERRED
HumanIL103586interleukin 10
INFERRED
HumanIL23558interleukin 2
INFERRED
HumanIFNG3458interferon, gamma
INFERRED
HumanHLA-DQB13119
INFERRED
HumanHLA-DQA13117
INFERRED
HumanHLA-DOA3111
Click here to display 18 evidence detail records.
HumanHLA-DMA3108
Click here to display 18 evidence detail records.
HumanCSF21437colony stimulating factor 2 (granulocyte-macrophage)
INFERRED
HumanCD74972CD74 molecule, major histocompatibility complex, class II invariant chain
Click here to display 18 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0005041abnormal antigen presentation via MHC class II0self