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Details
Link-It Detail - Jax Mouse Phenotype - abnormal regulatory T cell physiology
Debug Stats
  • ### Total Build Time: 41 ms 21.440 KB
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Jax Mouse Phenotype (1)
abnormal regulatory T cell physiology MP:0004946
Definition (1)
any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function
Parents (1)
img abnormal T cell physiology MP:0002444
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal T cell physiology MP:0002444
Genes (26)

Species:
human : 26
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Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanRNF12879589ring finger protein 128, E3 ubiquitin protein ligase
Click here to display 40 evidence detail records.
HumanFOXP350943forkhead box P3
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HumanCD27429126CD274 molecule
Click here to display 40 evidence detail records.
HumanLAT27040linker for activation of T cells
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HumanDICER123405dicer 1, ribonuclease type III
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HumanIKZF222807IKAROS family zinc finger 2 (Helios)
Click here to display 40 evidence detail records.
HumanZAP707535zeta-chain (TCR) associated protein kinase 70kDa
Click here to display 40 evidence detail records.
HumanTNFRSF47293tumor necrosis factor receptor superfamily, member 4
Click here to display 40 evidence detail records.
HumanSTAT5B6777signal transducer and activator of transcription 5B
Click here to display 40 evidence detail records.
HumanSELL6402selectin L
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HumanCCL16346chemokine (C-C motif) ligand 1
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HumanRXRA6256retinoid X receptor, alpha
Click here to display 40 evidence detail records.
HumanIL103586interleukin 10
Click here to display 40 evidence detail records.
HumanIL9R3581interleukin 9 receptor
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HumanIL2RA3559interleukin 2 receptor, alpha
Click here to display 40 evidence detail records.
HumanIL23558interleukin 2
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HumanFOXO12308forkhead box O1
Click here to display 40 evidence detail records.
HumanEMR12015egf-like module containing, mucin-like, hormone receptor-like 1
Click here to display 40 evidence detail records.
HumanDTX11840deltex homolog 1 (Drosophila)
Click here to display 40 evidence detail records.
HumanCTLA41493cytotoxic T-lymphocyte-associated protein 4
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HumanCCR71236chemokine (C-C motif) receptor 7
Click here to display 40 evidence detail records.
HumanCD28940CD28 molecule
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HumanCD247919CD247 molecule
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HumanCD3E916CD3e molecule, epsilon (CD3-TCR complex)
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HumanAIRE326autoimmune regulator
Click here to display 40 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0004946abnormal regulatory T cell physiology0self