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Details
Link-It Detail - Jax Mouse Phenotype - abnormal T cell selection
Debug Stats
  • ### Total Build Time: 75 ms 37.279 KB
  • CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 378 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 348 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 586 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 1.037 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 9.648 KB
  • CONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=72 ms Completed: 72 ms rowSize= 24.005 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.163 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
abnormal T cell selection MP:0004917
Definition (1)
any anomaly in the process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation
Parents (1)
img abnormal T cell differentiation MP:0002145
Children (2)
img abnormal positive T cell selection MP:0004919
img abnormal negative T cell selection MP:0004918
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539710img abnormal T cell differentiation MP:0002145
img mammalian phenotype MP:0000001img immune system phenotype MP:000538710img abnormal T cell differentiation MP:0002145
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:000539711img abnormal T cell differentiation MP:0002145
img mammalian phenotype MP:0000001img immune system phenotype MP:00053879img abnormal T cell differentiation MP:0002145
img mammalian phenotype MP:0000001img cellular phenotype MP:00053848img abnormal T cell differentiation MP:0002145
img mammalian phenotype MP:0000001img hematopoietic system phenotype MP:00053979img abnormal T cell differentiation MP:0002145
img mammalian phenotype MP:0000001img immune system phenotype MP:00053878img abnormal T cell differentiation MP:0002145
Genes (40)

Species:
human : 40
Page Size
Current 25
  Page 1 of 2
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanTHEMIS387357thymocyte selection associated
INFERRED
HumanBCL11B64919B-cell CLL/lymphoma 11B (zinc finger protein)
INFERRED
HumanSIT127240signaling threshold regulating transmembrane adaptor 1
img Jax MP, Pubmed Id: 14647385, MOUSE PHENOTYPE ID: MGI:99613
img Jax MP, Pubmed Id: 16107703, MOUSE PHENOTYPE ID: MGI:1889342
img Jax MP, Pubmed Id: 14770179, MOUSE PHENOTYPE ID: MGI:102853
img Jax MP
img Jax MP, Pubmed Id: 12065839, MOUSE PHENOTYPE ID: MGI:1342293
HumanLAT27040linker for activation of T cells
img Jax MP
img Jax MP, Pubmed Id: 16107703, MOUSE PHENOTYPE ID: MGI:1889342
img Jax MP, Pubmed Id: 14647385, MOUSE PHENOTYPE ID: MGI:99613
img Jax MP, Pubmed Id: 14770179, MOUSE PHENOTYPE ID: MGI:102853
img Jax MP, Pubmed Id: 12065839, MOUSE PHENOTYPE ID: MGI:1342293
HumanPRSS1610279protease, serine, 16 (thymus)
INFERRED
HumanRASGRP110125RAS guanyl releasing protein 1 (calcium and DAG-regulated)
INFERRED
HumanGIT29815G protein-coupled receptor kinase interacting ArfGAP 2
INFERRED
HumanTOX9760thymocyte selection-associated high mobility group box
INFERRED
HumanTNFRSF11A8792tumor necrosis factor receptor superfamily, member 11a, NFKB activator
INFERRED
HumanTNFSF108743tumor necrosis factor (ligand) superfamily, member 10
INFERRED
HumanTNFRSF258718tumor necrosis factor receptor superfamily, member 25
INFERRED
HumanFOXN18456forkhead box N1
INFERRED
HumanZAP707535zeta-chain (TCR) associated protein kinase 70kDa
img Jax MP, Pubmed Id: 12065839, MOUSE PHENOTYPE ID: MGI:1342293
img Jax MP, Pubmed Id: 14770179, MOUSE PHENOTYPE ID: MGI:102853
img Jax MP, Pubmed Id: 14647385, MOUSE PHENOTYPE ID: MGI:99613
img Jax MP, Pubmed Id: 16107703, MOUSE PHENOTYPE ID: MGI:1889342
img Jax MP
HumanVAV17409vav 1 guanine nucleotide exchange factor
INFERRED
HumanTAPBP6892TAP binding protein (tapasin)
INFERRED
HumanSLA6503Src-like-adaptor
INFERRED
HumanPTPRC5788protein tyrosine phosphatase, receptor type, C
INFERRED
HumanPTPN25771protein tyrosine phosphatase, non-receptor type 2
INFERRED
HumanMAPK15594mitogen-activated protein kinase 1
INFERRED
HumanPRKCQ5588protein kinase C, theta
INFERRED
HumanPRKCH5583protein kinase C, eta
INFERRED
HumanPPP3R15534protein phosphatase 3, regulatory subunit B, alpha
INFERRED
HumanPPP4C5531protein phosphatase 4, catalytic subunit
INFERRED
HumanLCP23937lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
INFERRED
HumanITK3702IL2-inducible T-cell kinase
INFERRED
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0004917abnormal T cell selection0self