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Details
Link-It Detail - Jax Mouse Phenotype - abnormal B cell physiology
Debug Stats
  • ### Total Build Time: 1,503 ms 26.409 KB
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  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
abnormal B cell physiology MP:0002459
Definition (1)
any functional anomaly of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens
Synonyms (1)
"B-cell dysfunction" EXACT
Parents (2)
img abnormal lymphocyte physiology MP:0003945
img abnormal professional antigen presenting cell physiology MP:0002452
Children (9)
img abnormal B lymphocyte antigen presentation MP:0002453
img abnormal class switch recombination MP:0004816
img abnormal memory B cell physiology MP:0008194
img abnormal B cell apoptosis MP:0008781
img abnormal immunoglobulin level MP:0002490
img abnormal marginal zone B cell physiology MP:0008193
img abnormal follicular B cell physiology MP:0008191
img abnormal B cell activation MP:0008217
img abnormal germinal center B cell physiology MP:0008192
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img immune system phenotype MP:00053877img abnormal lymphocyte physiology MP:0003945
img mammalian phenotype MP:0000001img immune system phenotype MP:00053876img abnormal professional antigen presenting cell physiology MP:0002452
Genes (477)

Species:
human : 477
Page Size
Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanCOMMD3-BMI1100532731
INFERRED
HumanGIMAP1-GIMAP5100527949
Click here to display 203 evidence detail records.
HumanIGLL5100423062immunoglobulin lambda-like polypeptide 5
INFERRED
HumanCCR2729230chemokine (C-C motif) receptor 2
INFERRED
HumanPIM3415116pim-3 oncogene
INFERRED
HumanINCA1388324inhibitor of CDK, cyclin A1 interacting protein 1
INFERRED
HumanNLRP10338322NLR family, pyrin domain containing 10
INFERRED
HumanATP11C286410ATPase, class VI, type 11C
INFERRED
HumanTAB3257397TGF-beta activated kinase 1/MAP3K7 binding protein 3
Click here to display 203 evidence detail records.
HumanGAPT202309GRB2-binding adaptor protein, transmembrane
INFERRED
HumanAPLF200558aprataxin and PNKP like factor
INFERRED
HumanNLRP6171389NLR family, pyrin domain containing 6
INFERRED
HumanBTLA151888B and T lymphocyte associated
INFERRED
HumanRC3H1149041ring finger and CCCH-type domains 1
INFERRED
HumanTICAM1148022toll-like receptor adaptor molecule 1
Click here to display 203 evidence detail records.
HumanDSG4147409desmoglein 4
INFERRED
HumanIL31RA133396interleukin 31 receptor A
INFERRED
HumanFCRLB127943Fc receptor-like B
INFERRED
HumanGABPB2126626GA binding protein transcription factor, beta subunit 2
INFERRED
HumanSPNS2124976spinster homolog 2 (Drosophila)
Click here to display 203 evidence detail records.
HumanPIK3AP1118788phosphoinositide-3-kinase adaptor protein 1
INFERRED
HumanTNFRSF13C115650tumor necrosis factor receptor superfamily, member 13C
Click here to display 203 evidence detail records.
HumanTIRAP114609toll-interleukin 1 receptor (TIR) domain containing adaptor protein
INFERRED
HumanIL17F112744interleukin 17F
INFERRED
HumanFNIP196459folliculin interacting protein 1
Click here to display 203 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0002459abnormal B cell physiology0self