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Details
Link-It Detail - Jax Mouse Phenotype - abnormal type II pneumocyte morphology
Debug Stats
  • ### Total Build Time: 302 ms 24.083 KB
  • CONCEPT_NAME gt=9 ms Completed: 9 ms rowSize= 404 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
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  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 210 bytes
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  • CONCEPT_PARENTS gt=14 ms Completed: 14 ms rowSize= 609 bytes
  • CONCEPT_CHILDREN gt=12 ms Completed: 12 ms rowSize= 1.508 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=108 ms Completed: 108 ms rowSize= 2.974 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=150 ms Completed: 150 ms rowSize= 16.444 KB
  • CONCEPT_XREFS gt=5 ms Completed: 5 ms rowSize= 1.176 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
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Jax Mouse Phenotype (1)
abnormal type II pneumocyte morphology MP:0002275
Definition (1)
any structural anomaly of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored
Synonyms (1)
"abnormal type 2 alveolar epithelial cells morphology" EXACT
Parents (1)
img abnormal pulmonary alveolus epithelial cell morphology MP:0002273
Children (3)
img increased type II pneumocyte number MP:0010810
img decreased type II pneumocyte number MP:0010811
img abnormal alveolar lamellar body morphology MP:0010813
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img respiratory system phenotype MP:000538810img abnormal pulmonary alveolus epithelial cell morphology MP:0002273
img mammalian phenotype MP:0000001img respiratory system phenotype MP:00053888img abnormal pulmonary alveolus epithelial cell morphology MP:0002273
Genes (51)

Species:
human : 51
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Current 25
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanGPR116221395G protein-coupled receptor 116
Click here to display 43 evidence detail records.
HumanBMPER168667BMP binding endothelial regulator
INFERRED
HumanLRRK2120892leucine-rich repeat kinase 2
Click here to display 43 evidence detail records.
HumanHOPX84525HOP homeobox
Click here to display 43 evidence detail records.
HumanITCH83737itchy E3 ubiquitin protein ligase
Click here to display 43 evidence detail records.
HumanNABP279035nucleic acid binding protein 2
Click here to display 43 evidence detail records.
HumanTMEM38B55151transmembrane protein 38B
Click here to display 43 evidence detail records.
HumanERRFI154206ERBB receptor feedback inhibitor 1
INFERRED
HumanABCA1226154ATP-binding cassette, sub-family A (ABC1), member 12
Click here to display 43 evidence detail records.
HumanCBY125776chibby homolog 1 (Drosophila)
Click here to display 43 evidence detail records.
HumanRAB3823682RAB38, member RAS oncogene family
Click here to display 43 evidence detail records.
HumanFSTL111167follistatin-like 1
Click here to display 43 evidence detail records.
HumanPTGES310728prostaglandin E synthase 3 (cytosolic)
INFERRED
HumanCITED210370Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Click here to display 43 evidence detail records.
HumanDOK29046docking protein 2, 56kDa
INFERRED
HumanAP3B18546adaptor-related protein complex 3, beta 1 subunit
Click here to display 43 evidence detail records.
HumanNKX2-17080
Click here to display 43 evidence detail records.
HumanTCF216943transcription factor 21
INFERRED
HumanSTAT36774signal transducer and activator of transcription 3 (acute-phase response factor)
INFERRED
HumanSFTPC6440surfactant protein C
INFERRED
HumanSFTPB6439surfactant protein B
Click here to display 43 evidence detail records.
HumanPTHLH5744parathyroid hormone-like hormone
Click here to display 43 evidence detail records.
HumanPTEN5728phosphatase and tensin homolog
Click here to display 43 evidence detail records.
HumanMAPK65597mitogen-activated protein kinase 6
Click here to display 43 evidence detail records.
HumanNOS34846nitric oxide synthase 3 (endothelial cell)
Click here to display 43 evidence detail records.
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0002275abnormal type II pneumocyte morphology0self