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Details
Link-It Detail - Jax Mouse Phenotype - optic nerve atrophy
Debug Stats
  • ### Total Build Time: 74 ms 89.882 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 366 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 511 bytes
  • CONCEPT_SYNONYM gt=0 Completed: 0 ms rowSize= 180 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=27 ms Completed: 27 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=8 ms Completed: 8 ms rowSize= 586 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 2.916 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=31 ms Completed: 31 ms rowSize= 84.052 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.157 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Jax Mouse Phenotype (1)
optic nerve atrophy MP:0001059
Definition (1)
acquired diminution of the size of the second cranial nerve which is responsible for conveying visual information from the retina to the brain, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
Synonyms (1)
"atrophy of optic nerve" EXACT
Parents (1)
img abnormal optic nerve morphology MP:0001330
Ancestral Roots
RootRoot Plus OneDepthParent
img mammalian phenotype MP:0000001img vision/eye phenotype MP:00053916img abnormal optic nerve morphology MP:0001330
img mammalian phenotype MP:0000001img nervous system phenotype MP:00036317img abnormal optic nerve morphology MP:0001330
Genes (9)

Species:
human : 9
SpeciesGeneGeneIdGene NameEvidence
HumanPRSS56646960protease, serine, 56
img Jax MP, Pubmed Id: 19109949, MOUSE PHENOTYPE ID: MGI:102524
img Jax MP, Pubmed Id: 8589526, MOUSE PHENOTYPE ID: MGI:1915443
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 16794820, MOUSE PHENOTYPE ID: MGI:2143311
img Jax MP, Pubmed Id: 21532570, MOUSE PHENOTYPE ID: MGI:1916703
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 17470285, MOUSE PHENOTYPE ID: MGI:1929059
img Jax MP, Pubmed Id: 22922231, MOUSE PHENOTYPE ID: MGI:1914544
HumanRYBP23429RING1 and YY1 binding protein
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 19109949, MOUSE PHENOTYPE ID: MGI:102524
img Jax MP, Pubmed Id: 8589526, MOUSE PHENOTYPE ID: MGI:1915443
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 17470285, MOUSE PHENOTYPE ID: MGI:1929059
img Jax MP, Pubmed Id: 16794820, MOUSE PHENOTYPE ID: MGI:2143311
img Jax MP, Pubmed Id: 22922231, MOUSE PHENOTYPE ID: MGI:1914544
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 21532570, MOUSE PHENOTYPE ID: MGI:1916703
HumanGPNMB10457glycoprotein (transmembrane) nmb
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 22922231, MOUSE PHENOTYPE ID: MGI:1914544
img Jax MP, Pubmed Id: 16794820, MOUSE PHENOTYPE ID: MGI:2143311
img Jax MP, Pubmed Id: 19109949, MOUSE PHENOTYPE ID: MGI:102524
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 21532570, MOUSE PHENOTYPE ID: MGI:1916703
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 8589526, MOUSE PHENOTYPE ID: MGI:1915443
img Jax MP, Pubmed Id: 17470285, MOUSE PHENOTYPE ID: MGI:1929059
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
HumanIKBKAP8518inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
img Jax MP, Pubmed Id: 21532570, MOUSE PHENOTYPE ID: MGI:1916703
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 16794820, MOUSE PHENOTYPE ID: MGI:2143311
img Jax MP, Pubmed Id: 17470285, MOUSE PHENOTYPE ID: MGI:1929059
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 8589526, MOUSE PHENOTYPE ID: MGI:1915443
img Jax MP, Pubmed Id: 19109949, MOUSE PHENOTYPE ID: MGI:102524
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 22922231, MOUSE PHENOTYPE ID: MGI:1914544
HumanRPL246152ribosomal protein L24
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 19109949, MOUSE PHENOTYPE ID: MGI:102524
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 22922231, MOUSE PHENOTYPE ID: MGI:1914544
img Jax MP, Pubmed Id: 17470285, MOUSE PHENOTYPE ID: MGI:1929059
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 21532570, MOUSE PHENOTYPE ID: MGI:1916703
img Jax MP, Pubmed Id: 16794820, MOUSE PHENOTYPE ID: MGI:2143311
img Jax MP, Pubmed Id: 8589526, MOUSE PHENOTYPE ID: MGI:1915443
HumanPOU4F25458POU class 4 homeobox 2
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 22922231, MOUSE PHENOTYPE ID: MGI:1914544
img Jax MP, Pubmed Id: 21532570, MOUSE PHENOTYPE ID: MGI:1916703
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 17470285, MOUSE PHENOTYPE ID: MGI:1929059
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 19109949, MOUSE PHENOTYPE ID: MGI:102524
img Jax MP, Pubmed Id: 16794820, MOUSE PHENOTYPE ID: MGI:2143311
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 8589526, MOUSE PHENOTYPE ID: MGI:1915443
HumanNDUFS44724NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
img Jax MP, Pubmed Id: 22922231, MOUSE PHENOTYPE ID: MGI:1914544
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 8589526, MOUSE PHENOTYPE ID: MGI:1915443
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 19109949, MOUSE PHENOTYPE ID: MGI:102524
img Jax MP, Pubmed Id: 21532570, MOUSE PHENOTYPE ID: MGI:1916703
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 16794820, MOUSE PHENOTYPE ID: MGI:2143311
img Jax MP, Pubmed Id: 17470285, MOUSE PHENOTYPE ID: MGI:1929059
HumanCLCN71186chloride channel, voltage-sensitive 7
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 21532570, MOUSE PHENOTYPE ID: MGI:1916703
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 8589526, MOUSE PHENOTYPE ID: MGI:1915443
img Jax MP, Pubmed Id: 16794820, MOUSE PHENOTYPE ID: MGI:2143311
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 17470285, MOUSE PHENOTYPE ID: MGI:1929059
img Jax MP, Pubmed Id: 19109949, MOUSE PHENOTYPE ID: MGI:102524
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 22922231, MOUSE PHENOTYPE ID: MGI:1914544
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
HumanBBS4585Bardet-Biedl syndrome 4
img Jax MP, Pubmed Id: 8589526, MOUSE PHENOTYPE ID: MGI:1915443
img Jax MP, Pubmed Id: 17470285, MOUSE PHENOTYPE ID: MGI:1929059
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 16794820, MOUSE PHENOTYPE ID: MGI:2143311
img Jax MP, Pubmed Id: 19109949, MOUSE PHENOTYPE ID: MGI:102524
img Jax MP, Pubmed Id: 11207362, MOUSE PHENOTYPE ID: MGI:1347048
img Jax MP, Pubmed Id: 10192392, MOUSE PHENOTYPE ID: MGI:1934765
img Jax MP, Pubmed Id: 20534480, MOUSE PHENOTYPE ID: MGI:1343135
img Jax MP, Pubmed Id: 21532570, MOUSE PHENOTYPE ID: MGI:1916703
img Jax MP, Pubmed Id: 22922231, MOUSE PHENOTYPE ID: MGI:1914544
XRefs (1)

XRef Types:
mp : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
MPimg MP:0001059optic nerve atrophy0self