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Genes (51)
Species: human : 51 | |
Human | GOLM1 | 51280 | golgi membrane protein 1 | increased expression of GP73 in hepatocytes appears to be a general feature of advanced liver disease, and may be regulated via distinct pathways that involve hepatotropic viruses or cytokines | Human | GNMT | 27232 | glycine N-methyltransferase | compound heterzygotes in the gene that encodes GNMT have evidence of mild liver disease | Human | PEMT | 10400 | phosphatidylethanolamine N-methyltransferase | Title:Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).|Association:Not Found|Conclusion:Not Found | Human | H6PD | 9563 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | Mutations found in beta thassemia patients complicated by liver disease | Human | TP53 | 7157 | tumor protein p53 | P-53 over-expression can occur in initial stages of HCV-related liver disease | Human | TNF | 7124 | tumor necrosis factor | study found no evidence of an interaction between alcohol consumption and TNF-alpha gene polymorphisms in relation to TNF-alpha levels; carriers of the TNF -238A allele tended to have a higher prevalence of advanced liver disease than -238G homozygotes TNF-alpha secreted by host cells other than antigen-specific cytotoxic T lymphocytes (CTL) plays a critical role in the acute progression of necroinflammatory liver disease, and it may cause acute hepatitis to develop into lethal liver disease Title:Are genetic polymorphisms of tumour necrosis factor alpha, interleukin-10, CD14 endotoxin receptor or manganese superoxide dismutase associated with alcoholic liver disease?|Association:Not Found|Conclusion:No association was found between the previously implicated polymorphisms of TNF-alpha, IL-10, CD14 and MnSOD, either individually or simultaneously, and the presence of established ALD. | Human | TAP2 | 6891 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | Title:[Involvement of TAP2 and LMP7 gene polymorphisms in HCV infection]|Association:Y|Conclusion:The TAP2 polymorphism may be closely associated with low hepatitis activity, whereas the LMP7 polymorphism influences the efficacy of IFN treatment and can be a useful predictive parameter in HCV patients with a low viral load. | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | Title:Are genetic polymorphisms of tumour necrosis factor alpha, interleukin-10, CD14 endotoxin receptor or manganese superoxide dismutase associated with alcoholic liver disease?|Association:Not Found|Conclusion:No association was found between the previously implicated polymorphisms of TNF-alpha, IL-10, CD14 and MnSOD, either individually or simultaneously, and the presence of established ALD. | Human | PSMB8 | 5696 | proteasome (prosome, macropain) subunit, beta type, 8 | Title:[Involvement of TAP2 and LMP7 gene polymorphisms in HCV infection]|Association:Not Found|Conclusion:The TAP2 polymorphism may be closely associated with low hepatitis activity, whereas the LMP7 polymorphism influences the efficacy of IFN treatment and can be a useful predictive parameter in HCV patients with a low viral load. | Human | RELN | 5649 | reelin | data show that Reelin's levels and glycosylation are altered in plasma from patients with cirrhosis, thereby supporting that Reelin is involved in the pathogenesis of liver disease | Human | SERPINA1 | 5265 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | single nucleotide polymorphism confers a significant risk for liver disease in homozygous ZZ children Title:Chronic liver disease in heterozygous alpha1-antitrypsin deficiency PiZ.|Association:Not Found|Conclusion:Patients with heterozygous AATD of PiZ type bear an increased risk for chronic liver disease. If at all, this genetic defect will become clinically relevant only in middle-aged or old adults. It rarely causes liver cirrhosis even without concurrent liver disease. It can aggravate or can be aggravated by advanced coexistent chronic liver diseases. PiZ immunohistochemistry is an easy, highly specific method to detect this metabolic defect on liver biopsies. The PiMZ alpha1ATD heterozygous state may have a role in worsening liver disease due to hepatitis C virus or nonalcoholic fatty liver disease | Human | PAK2 | 5062 | p21 protein (Cdc42/Rac)-activated kinase 2 | The opposing effects of Core protein on the transcription pf P21 might be important in the progression of liver disease in HCV-positive patients | Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | Increased intrahepatic iNOS expression and nitrotyrosine accumulation in biliary cirrhosis and autoimmune hepatitis, related to histological severity of liver disease | Human | MPO | 4353 | myeloperoxidase | Title:A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection.|Association:Y|Conclusion:We found that patients with the MPO GA/AA genotype were more likely to have advanced fibrosis scores | Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Title:Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease.|Association:Not Found|Conclusion:These findings suggest that MMP-1, MMP-3, and MMP-9 gene polymorphisms account for some of the variability in the progression of HCV-related chronic liver diseases. | Human | LMAN1 | 3998 | lectin, mannose-binding, 1 | Title:The mannose binding lectin gene influences the severity of chronic liver disease in cystic fibrosis|Association:Not Found|Conclusion:These data highlight the crucial role of mannose binding lectin in the clinical outcome of cystic fibrosis, as it has recently been shown that the mannose binding lectin gene is a modulating gene of the respiratory involvement in cystic fibrosis patients. | Human | KRT18 | 3875 | keratin 18 | Mutation of this protein is a risk factor for liver disease of multiple etiologies | Human | KRT8 | 3856 | keratin 8 | A study of 1668 liver disease patients showed that there is no association between the KRT8 mutations Y54H and G62C and chronic liver disease Title:Keratins as susceptibility genes for end-stage liver disease.|Association:Not Found|Conclusion:The overall frequency of keratin 8 and 18 variants was 12.4% in 467 liver disease explants and 3.7% in 349 blood bank controls (P < .0001). Variants can alter keratin solubility or phosphorylation and may render individuals susceptible to end-stage liver disease, depending on their genetic background and exposure to other insults, such as alcohol or viral infection. | Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | IL-18 serum concentrations are associated in apparently healthy humans with plasma concentrations of various liver chemistry tests; IL-18 could contribute to the development of liver disease associated with insulin resistance | Human | IL10 | 3586 | interleukin 10 | Title:Are genetic polymorphisms of tumour necrosis factor alpha, interleukin-10, CD14 endotoxin receptor or manganese superoxide dismutase associated with alcoholic liver disease?|Association:Not Found|Conclusion:No association was found between the previously implicated polymorphisms of TNF-alpha, IL-10, CD14 and MnSOD, either individually or simultaneously, and the presence of established ALD. Title:Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease|Association:Not Found|Conclusion:In conclusion, antigenic stimulation by HER-modified CYP2E1 combined with an impaired control of T-cell proliferation by CTLA-4 mutation promotes the development of anti-CYP2E1 autoantibodies that might contribute to alcohol-induced liver injury. | Human | IGFBP6 | 3489 | insulin-like growth factor binding protein 6 | determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation | Human | IGFBP3 | 3486 | insulin-like growth factor binding protein 3 | determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation | Human | IGFBP2 | 3485 | insulin-like growth factor binding protein 2, 36kDa | determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation | Human | IGFBP1 | 3484 | insulin-like growth factor binding protein 1 | determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation Elevation of IGFBP-1 is associated with the metabolic disturbances in liver disease | Human | IGF2 | 3481 | insulin-like growth factor 2 (somatomedin A) | determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation |
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