Human | UTS2D | 257313 | | vascular remodelling processes in conjunction with enhanced vasoconstriction are involved in the pathogenesis of pulmonary hypertension; UII may play a novel role in the pathogenesis of this disorder |
Human | NOX4 | 50507 | NADPH oxidase 4 | In lungs from patients with idiopathic pulmonary arterial hypertension, NOX4 expression in the tunica media was 2.5-fold upregulated, supporting an important role for NOX4 in the vascular remodeling associated with pulmonary hypertension |
Human | GREM1 | 26585 | gremlin 1, DAN family BMP antagonist | the mechanisms of pulmonary hypertension and vascular loss in chronic lung disease and identifies gremlin 1 as a potentially important mediator of vascular changes in hypoxic pulmonary hypertension |
Human | UTS2 | 10911 | urotensin 2 | hU-II may play a novel role in pulmonary hypertension by promoting remodeling processes via activation of NADPH oxidases |
Human | ARHGEF6 | 9459 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | Data suggest that Rac-dependent activation of the NFkappaB pathway may be a critical element promoting thrombin-induced tissue factor expression and activity, and thus a prothrombotic state in pulmonary hypertension |
Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | The increased values of VEGF, PLA2-LDL and P-selectin in patients with long standing pulmonary hypertension are related to severe endothelial dysfunction and may have prognostic values |
Human | VWF | 7450 | von Willebrand factor | data suggest a common mechanism for platelet and vWF abnormalities in these chronically hypoxic pulmonary hypertension patients |
Human | AVSD1 | 7446 | atrioventricular septal defect 1 | |
Human | TRPC6 | 7225 | transient receptor potential cation channel, subfamily C, member 6 | TRPC channel overexpression may be partially responsible for the increased pulmonary artert smooth muscle cell proliferation and pulmonary vascular medial hypertrophy in pulmonary hypertension patients |
Human | TGFA | 7039 | transforming growth factor, alpha | Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing human transforming growth factor-alpha |
Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | 5-HTT gene polymorphism appears to determine the severity of pulmonary hypertension in hypoxemic patients with COPD |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | PPARgamma expression is reduced or lacking in all of the angiogenic plexiform lesions of pulmonary hypertensive lungs and in the vascular lesions of a rat model of severe PH (pulmonary hypertension) Peroxisome proliferator-activated receptor gamma is expressed in the lung and pulmonary vasculature, and its expression is reduced in the vascular lesions of patients with pulmonary hypertension Results describe an antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension |
Human | NPPB | 4879 | natriuretic peptide B | Pulmonary hypertension is associated with NT-proBNP elevation and diastolic impairment in congenital diaphragmatic hernia infants BNP levels parallel changes in pulmonary hemodynamics and functional parameters in pulmonary hypertension |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Title:Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD.|Association:Y|Conclusion:In conclusion, BB-type polymorphism of the eNOS gene has been associated with PH in addition to hypoxemia. However, ACE gene polymorphism was not found to be associated with PH. |
Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | The observed decrease in pulmonary expression of iNOS in patients with CDH suggests a potential role in the pathogenesis of pulmonary hypertension in newborns with congenital diaphragmatic hernia |
Human | JUN | 3725 | jun proto-oncogene | The Ca2+-mediated increase in AP-1 binding may play an important role in upregulating AP-1-responsive gene expression, in stimulating pulmonary vascular cell proliferation and in pulmonary vascular remodeling in hypoxia-mediated pulmonary hypertension |
Human | TNC | 3371 | tenascin C | Link between BMPR2 mutations and induction of Prx 1-dependent tenascin-c gene transcription in familial pulmonary hypertension smooth muscle cells |
Human | GJA1 | 2697 | gap junction protein, alpha 1, 43kDa | |
Human | GBA | 2629 | glucosidase, beta, acid | |
Human | SLC37A4 | 2542 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | |
Human | FLNA | 2316 | filamin A, alpha | |
Human | EDN1 | 1906 | endothelin 1 | These data suggest that secreted HIV gp120 proteins induce lung endothelial cell injury and could contribute to the development of HIV-associated pulmonary hypertension Assessment of ET plasmatic levels for detection and monitoring of pulmonary hypertension during systemic sclerosis is warranted in larger prospective studies |
Human | CTGF | 1490 | connective tissue growth factor | CTGF upregulation in arterial vascular smooth muscle cells of the lung is associated with the pathogenesis of pulmonary hypertension |
Human | COL1A2 | 1278 | collagen, type I, alpha 2 | |