Human | MIR21 | 406991 | microRNA 21 | miR-21 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Rac1-dependent Noxs play a critical role in activating c-Src following hypoxia/reoxygenation injury[NADPH oxidase 2] |
Human | LOC145908 | 145908 | | the combination of hypoxia and reoxygenation results in a G2 checkpoint response that is dependent on the tumor suppressor Chk2 and that this checkpoint response is essential for tumor cell adaptation to changes |
Human | DCD | 117159 | dermcidin | Expression of dermcidin in human primary tumours appears highly variable and is not induced substantially by hypoxia/oxidative stress in cell line model systems |
Human | EGLN3 | 112399 | egl-9 family hypoxia-inducible factor 3 | Mechanism underlying the regulation of PHD3 availability and activity in hypoxia by the E3 ligase Siah2 PHD-dependent oxygen-sensing recruits both the hypoxia-inducible factor (HIF) and ATF-4 systems PHD1, PHD2, and PHD3 have roles in the regulation of hypoxia-inducible factor Chronic hypoxia not only increases the pool of PHDs but also overactivates the three PHD isoforms |
Human | EGLN2 | 112398 | egl-9 family hypoxia-inducible factor 2 | PHD1, PHD2, and PHD3 have roles in the regulation of hypoxia-inducible factor hypoxia releases repression of NFkappaB activity through decreased prolyl hydroxylase-dependent hydroxylation of IKKbeta |
Human | CHRDL1 | 91851 | chordin-like 1 | Hypoxia-induced upregulation of CHL-1 alters the homeostatic balance between BMP-4 and VEGF to synergize with VEGF in driving retinal angiogenesis |
Human | COL18A1 | 80781 | collagen, type XVIII, alpha 1 | Hypoxia down-regulates endostatin production by microvascular endothelial cells and pericytes Hypoxia downregulates the concentration of endostatin in the culture media of human endometrial stromal cells |
Human | SPHKAP | 80309 | SPHK1 interactor, AKAP domain containing | HIF-1 and HIF-2 have roles in SK1 upregulation during hypoxia in glioma cells |
Human | BHLHE41 | 79365 | basic helix-loop-helix family, member e41 | DEC1 and DEC2 may play a crucial role in the adaptation to hypoxia MLH1 is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2 |
Human | PDIA2 | 64714 | protein disulfide isomerase family A, member 2 | PDI has a role in conferring resistance to apoptosis under hypoxia and a potential role in the oxygen-sensing apparatus |
Human | HAMP | 57817 | hepcidin antimicrobial peptide | hypoxia lowers circulating prohepcidin concentrations in humans |
Human | TRIB3 | 57761 | tribbles homolog 3 (Drosophila) | This protein, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia |
Human | NDRG2 | 57447 | NDRG family member 2 | This study suggests that NDRG2 is a Hif-1 target gene and closely related with hypoxia-induced apoptosis in A549 cells |
Human | KDM3A | 55818 | lysine (K)-specific demethylase 3A | These findings demonstrate that JMJD1A can be stimulated by hypoxia both in vitro and in vivo involving binding of HIF-1 to a specific HRE in the JMJD1A promoter Results show that many genes regulated by hypoxia and HIF-1alpha show patterns of induction with JMJD (Jumonji-domain containing)1A and JMJD2B demonstrating robust, and JMJD2C more modest, up-regulation by hypoxia |
Human | HIF1AN | 55662 | hypoxia inducible factor 1, alpha subunit inhibitor | functional inactivation of HIF-alpha by stimulation of FIH-dependent p300 contributes to the YC-1-induced deregulation of hypoxia-induced genes FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor |
Human | MNS1 | 55329 | meiosis-specific nuclear structural 1 | A rat homologous protein was among the the nuclear proteins that change in abundance or form in response to prolonged hypoxia in the rat kidney fibroblasts |
Human | P4HTM | 54681 | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | This review summarizes recent progress in elucidating the molecular mechanisms of hypoxia-inducible factor (HIF)-1 activation, focusing on the role of oxygen-dependent asparaginyl hydroxylase in hypoxia signal transduction Data suggest that PH-4 is a novel hypoxia-inducible factor-prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia |
Human | EGLN1 | 54583 | egl-9 family hypoxia-inducible factor 1 | Critical for normal regulation of hypoxia-inducible factor Accumulated EGLN1 in hypoxia acts as a negative-feedback mechanism to modulate HIF-1alpha target gene expression PHD1, PHD2, and PHD3 have roles in the regulation of hypoxia-inducible factor |
Human | DDIT4 | 54541 | DNA-damage-inducible transcript 4 | co-transfection with antisense Sp1 oligonucleotide suggests that hypoxia induction of the RTP801 promoter is mediated by Sp1 |
Human | ERRFI1 | 54206 | ERBB receptor feedback inhibitor 1 | |
Human | CECR1 | 51816 | cat eye syndrome chromosome region, candidate 1 | findings show ADA2 is encoded by the CECR1 gene & belongs to novel family of ADA-related growth factors;ADA2 may be active in sites of inflammation during hypoxia & in areas of tumour growth where adenosine is elevated & extracellular pH is acidic |
Human | ANGPT4 | 51378 | angiopoietin 4 | the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma |
Human | KCNK9 | 51305 | potassium channel, subfamily K, member 9 | Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation |
Human | NRN1 | 51299 | neuritin 1 | By Northern blot, we confirm hypoxia-induced expression of insulin-like growth factor binding protein 3 (igfbp3), thioredoxin-interacting protein (txnip), neuritin (nrn1) |