Genes (41)
Species:
human : 41 | |
| Human | TRPM8 | 79054 | transient receptor potential cation channel, subfamily M, member 8 | TRPM8 axons diffusely innervate the skin and oral cavity of TRPM8 transgenic mice, terminating in nerve endings mediating distinct perceptions of innocuous cool, noxious cold, and first- and second-cold pain | | Human | WNK1 | 65125 | WNK lysine deficient protein kinase 1 | Impaired sensation in distal extremities (pain, temperature, position, touch) | | Human | TREM2 | 54209 | triggering receptor expressed on myeloid cells 2 | Pain and swelling in ankles and wrists after stress or injury beginning around age 20 years | | Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Ghrelin might ameliorate neuropathic pain by diminishing proinflammatory cytokines and regulating the pain system | | Human | GAL | 51083 | galanin/GMAP prepropeptide | The involvement of galanin is reviewed in the modulation of such functions as neurotransmitter release, memory, pain, depression, anxiety, obesity, gut motility, neuroendocrine regulation, development and neuroregeneration | | Human | SPTLC1 | 10558 | serine palmitoyltransferase, long chain base subunit 1 | Sharp, 'lightning'-like pain Distal sensory loss of all modalities (pain, temperature, touch, vibration) | | Human | MFN2 | 9927 | mitofusin 2 | Predominant loss of pain and temperature sensation | | Human | TRPA1 | 8989 | transient receptor potential cation channel, subfamily A, member 1 | trypsin or tryptase released in response to tissue inflammation might trigger the sensation of pain by TRPA1 activation | | Human | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | disruption of the RANKL-RANK axis with OPG inhibited tumor-induced osteoclastogenesis and decreased bone cancer pain | | Human | NPFF | 8620 | neuropeptide FF-amide peptide precursor | the findings from the early studies on the analgesic and morphine modulating activities suggested a role for NPFF in pain modulation--review | | Human | IKBKAP | 8518 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein | Decreased pain and temperature perception | | Human | TRPV1 | 7442 | transient receptor potential cation channel, subfamily V, member 1 | TRPV1 may be involved in pain mechanisms associated with cervical ripening and labor IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system These data provide the first clinical evidence that a TRPV1 antagonist may alleviate pain and hyperalgesia associated with inflammation and tissue injury | | Human | TYROBP | 7305 | TYRO protein tyrosine kinase binding protein | Pain and swelling in ankles and wrists after stress or injury beginning around age 20 years | | Human | TNF | 7124 | tumor necrosis factor | Polymorphisms in TNF-308G/A may be important modulators of pain treatment and control tumor necrosis factor alpha is not involved in the initiation of disc degeneration, but may be associated with further promotion of degenerative disarrangement and pain induction These findings support preclinical evidence that the local administration of tumor necrosis factor inhibitors may prove to be a safe and effective treatment for challenging pain conditions | | Human | TGFBI | 7045 | transforming growth factor, beta-induced, 68kDa | | | Human | TAC1 | 6863 | tachykinin, precursor 1 | Specific changes in CGRP and substance P at different levels of the central nervous system in the different models of pain (formalin test and nitroglycerin administration) | | Human | SCN9A | 6335 | sodium channel, voltage-gated, type IX, alpha subunit | Reddish discoloration, episodic, associated with pain review: Congenital Indifference to Pain patients assessed are homozygous or compound heterozygous for nonsense mutations at various locations throughout SCN9A, resulting in an early stop codon An SCN9A channelopathy causes congenital inability to experience pain Met1627Lys mutant SCN9A channels render dorsal root ganglion neurons hyperexcitable and provide a link between altered channel biophysics and pain in paroxysmal extreme pain disorder Reddish or purplish skin discoloration, episodic, associated with pain The contribution of Na(v)1.7 to acquired and inherited pain states and the absence of motor, cognitive and cardiac deficits in patients lacking this channel make it an attractive target for the treatment of neuropathic pain identified 10 mutations in the SCN9A gene encoding the sodium channel protein Nav1.7 in congenital indifference to pain variations of SCN9A can lead to complete inability to sense pain Skin flushing, episodic, associated with pain Mandibular and submandibular pain, episodic, triggered by eating and yawning | | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | This review covers factors influencing COX enzyme activity, the role of their products in the development and maintenance of pain and discusses recent safety concerns of COX-2 inhibitors Bupivacaine stimulates COX-2 gene expression after surgery, which is associated with higher PGE2 production and pain after the local anesthetic effect dissipates | | Human | PKLR | 5313 | pyruvate kinase, liver and RBC | congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency | | Human | P2RX7 | 5027 | purinergic receptor P2X, ligand-gated ion channel, 7 | the P2X(7) receptor, via regulation of mature IL-1beta production, plays a common upstream transductional role in the development of pain of neuropathic and inflammatory origin | | Human | OXT | 5020 | oxytocin/neurophysin I prepropeptide | reduced oxytocinergic function may be one of multiple biological factors contributing to the greater sensitivity to experimental ischemic pain, and to the greater burden of some types of clinical pain experienced by African Americans compared with Whites | | Human | OPRM1 | 4988 | opioid receptor, mu 1 | Fibromyalgia patients display reduced mu-opioid receptor availability in several brain regions associated with pain modulation, including nucleus accumbens, amygdala and the dorsal cingulate OPRM1 may be a pain-relevant gene Title:The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans.|Association:Y|Conclusion:The results indicate that the rare allele is associated with higher pressure pain thresholds. These results support previous contentions that OPRM1 may be a pain-relevant gene; however, replication of these findings is needed. Placebo treatment affected endogenous opioid activity in a number of predicted mu-opioid receptor-rich regions that play central roles in pain and affect Title:Anger Regulation Style, Postoperative Pain, and Relationship to the A118G Mu Opioid Receptor Gene Polymorphism: A Preliminary Study|Association:Not Found|Conclusion:These results suggest that the A118G SNP may moderate but not mediate the effects of anger-out on postoperative pain responses. | | Human | NTRK1 | 4914 | neurotrophic tyrosine kinase, receptor, type 1 | missense, insertion and deletion mutation in NTRK1 associated with congenital insensitivity to pain with anhidrosis congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive disorder caused by mutations in the neurotrophic tyrosine receptor kinase 1 (NTRK1) gene which encodes the receptor for nerve growth factor (NGF) | | Human | NGF | 4803 | nerve growth factor (beta polypeptide) | Both the annulus fibrosus and nucleus pulposus cells of the intervertebral disc (IVD) express the neurotrophins NGF and BDNF, factors that may influence and enhance innervation and pain in the degenerate IVD | | Human | KCNK2 | 3776 | potassium channel, subfamily K, member 2 | TREK1, the most thoroughly studied K(2P) channel, has a key role in the cellular mechanisms of neuroprotection, anaesthesia, pain and depression--{REVIEW} |
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