Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | a putative role of Ik6 in the development of B-lineage acute lymphoblastic leukemia, by activating the JAK2-STAT5 pathway and thus stimulating the production of Bcl-xl.[IK6] |
Human | UHMK1 | 127933 | U2AF homology motif (UHM) kinase 1 | Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia |
Human | TSGA10 | 80705 | testis specific, 10 | The RT-PCR of TSGA10 expression may help in detection of residual clonal cells leading to early diagnosis and better prognostic qualification of the acute lymphoblastic leukemia |
Human | TBL1XR1 | 79718 | transducin (beta)-like 1 X-linked receptor 1 | the TBL1XR1 gene was significantly under-expressed in acute lymphoblastic leukemia |
Human | AICDA | 57379 | activation-induced cytidine deaminase | AID is a BCR-ABL1-induced mutator in Philadelphia chromosome(+) acute lymphoblastic leukemia cells, which may be relevant to the particularly unfavorable prognosis of this leukemia subset expression in acute lymphoblastic leukemia L2 with t(14;18)(q32;q21) |
Human | SMPD3 | 55512 | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | Nucleotide sequencing of the highly conserved SMPD3 gene in a large panel of human cancers revealed mutations in 5 (5%) of 92 acute myeloid leukemias (AMLs) and 8 (6%) of 131 acute lymphoid leukemias (ALLs), but not in other tumor types |
Human | TTC12 | 54970 | tetratricopeptide repeat domain 12 | the TTC12 gene is hypermethylated in acute lymphoblastic leukemia |
Human | TLX3 | 30012 | T-cell leukemia homeobox 3 | INFERRED, Score=800, UMLKSK CUI: C1961102 |
Human | B3GAT1 | 27087 | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | first pediatric case describing coexpression of CD57 on B-lineage acute lymphoblastic leukemia |
Human | RAPGEF3 | 10411 | Rap guanine nucleotide exchange factor (GEF) 3 | Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells |
Human | IKZF1 | 10320 | IKAROS family zinc finger 1 (Ikaros) | findings suggest that genetic lesions resulting in the loss of Ikaros function are an important event in the development of BCR-ABL1 acute lymphoblastic leukaemia BCR-ABL1 induces aberrant splicing of IKAROS, which interferes with lineage identity and differentiation of pre-B lymphoblastic leukemia cells Constitutional deletion of the ZNFN1A1 gene in a Greig cephalopolysyndactyly patient may have resulted in an increased risk of acute lymphoblastic leukemia |
Human | ABCG2 | 9429 | ATP-binding cassette, sub-family G (WHITE), member 2 | Higher ABCG2 expression is associated with T-lineage acute lymphoblastic leukemia |
Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | Cellular resistance to TRAIL could be developed through phosphorylation (activation) of Akt and phosphorylation (inactivation) of PTEN in acute lymphoblastic leukemia cells |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | complex interaction between signaling from the CXCR4 receptor on acute lymphoblastic leukemia cells with those initiated by IL-7 & IL-3, suggesting CXCL12 may facilitate ALL proliferation by enhancing cytokine-signaling pathways in responsive cases |
Human | WT1 | 7490 | Wilms tumor 1 | The WT1 Genes were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblastic leukemia (ALL) |
Human | TPMT | 7172 | thiopurine S-methyltransferase | Polymorphisms in TPMT are associated with acute lymphoblastic leukemia in Asians and whites study provides the first data on the frequency of common TPMT variants in the Turkish population, based on analysis of pediatric patients with acute lymphoblastic leukemia |
Human | TPD52 | 7163 | tumor protein D52 | INFERRED, Score=800, UMLKSK CUI: C1961102 |
Human | TP73 | 7161 | tumor protein p73 | p73 gene inactivation might play an important role in the pathogenesis of acute lymphoblastic leukemia . The main mechanism of the loss expression would be the hypermethylation of p73 gene |
Human | TP53 | 7157 | tumor protein p53 | The Aberrant expression of p53 Genes were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblastic leukemia (ALL) |
Human | TNFRSF1A | 7132 | tumor necrosis factor receptor superfamily, member 1A | High levels of the soluble, 55-kilodalton isoform of tumor necrosis factor receptor in bone marrow are correlated with the clinical outcome of children with acute lymphoblastic leukemia in first recurrence |
Human | TERT | 7015 | telomerase reverse transcriptase | INFERRED, Score=800, UMLKSK CUI: C1961102 |
Human | TRD@ | 6964 | | TCR delta rearrangements--most frequently found in B precursor acute lymphoblastic leukemia--have been studied in clones isolated from normal adult B cells; two D segments (D delta 2 and D delta 3) are involved in the V-D rearrangement of healthy donors |
Human | TAL1 | 6886 | T-cell acute lymphocytic leukemia 1 | INFERRED, Score=800, UMLKSK CUI: C1961102 |
Human | SP1 | 6667 | Sp1 transcription factor | dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding |
Human | SLC19A1 | 6573 | solute carrier family 19 (folate transporter), member 1 | use of the A1/A2 5'UTR of RFC1 in acute lymphoblastic leukemia may confer a transport phenotype distinct from the other 5'UTRs due to altered translation efficiency and transport properties |