Genes (49)
Species: human : 49 | |
Human | TLR10 | 81793 | toll-like receptor 10 | common haplotype in the TLR10-TLR1-TLR6 gene cluster influences prostate cancer risk and clearly supports the need for further investigation of TLR genes in other populations The observed multiple associated SNPs at the TLR6-TLR1-TLR10 gene cluster were dependent and suggest the presence of a founder prostate cancer risk variant on this haplotype background | Human | CYP3A43 | 64816 | cytochrome P450, family 3, subfamily A, polypeptide 43 | Finds CYP3A43-Pro(340)Ala polymorphism prevalence differs by race and contributes to prostate cancer risk in African Americans | Human | ELAC2 | 60528 | elaC ribonuclease Z 2 | HPC2/ELAC2 and RNASEL may play a role, however minor, in prostate cancer risk among African American men polymorphism of the ELAC2 gene is associated with prostatic cancer risk in Japanese men | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | In a relatively genetically homogenous Tasmanian population, there is evidence for a significant association between variants within the AMACR gene and prostate cancer risk | Human | LZTS1 | 11178 | leucine zipper, putative tumor suppressor 1 | variation in the germline sequence is associated with prostate cancer risk | Human | ALDH1L1 | 10840 | aldehyde dehydrogenase 1 family, member L1 | None of the snps that defined 3 separate haplotype blocks in the FTHFD gene, rs2365004, rs11923466, rs2886059, rs10934751, rs2276731, rs1823213 and rs4646701 were associated with prostate cancer risk | Human | TLR6 | 10333 | toll-like receptor 6 | common haplotype in the TLR10-TLR1-TLR6 gene cluster influences prostate cancer risk and clearly supports the need for further investigation of TLR genes in other populations | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes are not associated with prostate cancer, while allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis | Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | evaluated prostate cancer risk in men with polymorphisms in the XRCC1 gene, a key player in base excision repair, across different strata of antioxidant intake | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | no correlation of VDR gene polymorphisms, as detected by Apal and Taql restriction fragments, in multiethnic Brazilian men (165 patients and 200 controls) with prostate cancer risk and parameters of disease severity was found various block C SNPs are associated with prostate cancer risk via a mechanism involving exposure to sunlight | Human | UGT2B17 | 7367 | UDP glucuronosyltransferase 2 family, polypeptide B17 | The UGT2B17 deletion polymorphism is associated with prostate cancer risk These findings show that the UGT2B17 deletion polymorphism is not associated with prostate cancer risk in Caucasians | Human | TP53 | 7157 | tumor protein p53 | Alleles and smoking play a significant role in modified prostate cancer risk in this study population | Human | TNF | 7124 | tumor necrosis factor | study does not support an association between TNF variants and prostate cancer risk Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes are not associated with prostate cancer, while allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis | Human | TLR1 | 7096 | toll-like receptor 1 | common haplotype in the TLR10-TLR1-TLR6 gene cluster influences prostate cancer risk and clearly supports the need for further investigation of TLR genes in other populations | Human | SRD5A2 | 6716 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | Distribution of polymorphisms in SRD5A2 and androgen receptor differed between prostate cancer low-risk population from Greenland and relatively high-risk Swedish male population SRD5A2 V89L polymorphism may modify the prostate cancer risk conferred by polymorphism of HSD3B2 After evaluating more than 6000 cases and 6000 controls, there is little evidence of a role for the SRD5A2 A49T variant in prostate cancer risk Association among polymorphisms in the steroid 5alpha-reductase type II (SRD5A2) gene, prostate cancer risk, and pathologic characteristics of prostate tumors Polymorphisms of SRD5A2 is associated with prostate cancer risk | Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | No overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms | Human | ABCE1 | 6059 | ATP-binding cassette, sub-family E (OABP), member 1 | common variation in the putative prostate cancer susceptibility gene, RNASEL, or its inhibitor does not contribute significantly to prostate cancer risk in Tobago Afro-Caribbean population | Human | RNASEL | 6041 | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) | Studies report an association between the RNASEL G1385A variant and prostate cancer risk; this variant does not appear to be implicated in the development of breast cancer The variant Arg462Gln has 3X less enzymatic activity than the wildtype and is significantly associated with prostate cancer risk (P=0.007) Compared with the genotype Asp/Asp, the Glu variant at the Asp541Glu polymorphism increases prostate cancer risk by <2-fold in Caucasians, regardless of family history of the disease common variation in the putative prostate cancer susceptibility gene, RNASEL, or its inhibitor does not contribute significantly to prostate cancer risk in Tobago Afro-Caribbean population polymorphic changes within the RNASEL gene may be associated with familial prostate cancer risk | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | large study of five PTGS2 SNPs does not support a strong association between PTGS2 variants and prostate cancer risk in non-Hispanic white men Our findings suggest that variation in COX2 is associated with prostate cancer risk | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | PPAR-gamma may play a role in prostate carcinogenesis; however, the Pro12Ala polymorphism does not appear to play a significant role in prostate cancer risk in this large cohort of male Finnish smokers | Human | OGG1 | 4968 | 8-oxoguanine DNA glycosylase | hOGG1 may have a role in the repair of 8-OH-dG adducts in prostate tissue and hOGG1 Ser326Cys polymorphism is associated with prostate cancer risk | Human | MUTYH | 4595 | mutY homolog (E. coli) | MYH mutations are unlikely to contribute to prostate cancer risk | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | our results do not provide strong support for the hypothesis that the MTHFR 677C-->T polymorphism is related to prostate cancer risk | Human | MSR1 | 4481 | macrophage scavenger receptor 1 | Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk | Human | LRP2 | 4036 | low density lipoprotein receptor-related protein 2 | Polymorphisms within the megalin gene for associations with prostate cancer risk and outcomes |
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