Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | MUC5B (mucin 5B) is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease |
Human | SFTPA1 | 653509 | surfactant protein A1 | Serum SP-A may represent a useful marker for predicting COPD in the preclinical stage |
Human | COPD | 260431 | Pulmonary disease, chronic obstructive, severe early-onset | Development of COPD correlates with mini- and microsatellite locus instability |
Human | IL27 | 246778 | interleukin 27 | Data suggest that polymorphisms in the IL-27 gene may play a role in the development of chronic obstructive pulmonary disease in Chinese population |
Human | FLCN | 201163 | folliculin | Genetic variation in folliculin does not appear to be a major risk factor for severe COPD |
Human | FBXO32 | 114907 | F-box protein 32 | Atrogin-1 mRNA expression was significantly increased in quadriceps of patients with COPD; transcriptional regulation of atrogin-1 and MuRF1 may occur via FoxO-1, but independently of AKT |
Human | TSLP | 85480 | thymic stromal lymphopoietin | There is distinct airways expression of TSLP and chemokines which preferentially attract T helper (Th) type 1- and Th2-type T cells, and influx of T cells bearing their receptors in asthma and chronic obstructive pulmonary disease human airway smooth muscle cells may play a role in chronic obstructive pulmonary disease airway inflammation via TSLP-dependent pathway |
Human | TRIM63 | 84676 | tripartite motif containing 63, E3 ubiquitin protein ligase | MuRF1 mRNA expression was significantly increased in quadriceps of patients with COPD; transcriptional regulation of atrogin-1 and MuRF1 may occur via FoxO-1, but independently of AKT |
Human | DUOX1 | 53905 | dual oxidase 1 | Results imply that the airway expression of Duox1 is diversely associated with smoking and chronic obstructive pulmonary disease |
Human | DUOX2 | 50506 | dual oxidase 2 | Results imply that the airway expression of Duox2 is diversely associated with smoking and chronic obstructive pulmonary disease |
Human | PLA2G2D | 26279 | phospholipase A2, group IID | These results suggest that sPLA2-IID may be one of the susceptibility genes that contribute to body weight loss in patients with COPD |
Human | SIRT1 | 23411 | sirtuin 1 | SIRT1 plays a pivotal role in regulation of NF-kappaB-dependent proinflammatory mediators in lungs of smokers and patients with COPD |
Human | ATF6 | 22926 | activating transcription factor 6 | Compared with COPD and donor lungs, protein levels of ER stress mediators, such as ATF-6 and ATF-4 and the apoptosis-inductor CHOP as well as XBP-1, were significantly elevated in lung homogenates and AECIIs of IPF lungs |
Human | GPR182 | 11318 | G protein-coupled receptor 182 | Hybridization in situ showed that ADMR mRNA expression was significantly higher in pulmonary artery walls in patients with chronic obstructive pulmonary disease |
Human | PARK7 | 11315 | parkinson protein 7 | the COPD patient lungs showed significantly decreased DJ-1 levels (a protein that stabilizes NRF2 protein) |
Human | CXCR6 | 10663 | chemokine (C-X-C motif) receptor 6 | Data show that CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity |
Human | SPAR | 9981 | | Title:[Surfactant protein A gene polymorphisms in chronic obstructive pulmonary disease]|Association:Y|Conclusion:Genetic polymorphism in SPA is associated with the development of COPD in the Chinese Hans. |
Human | GSTO1 | 9446 | glutathione S-transferase omega 1 | Glutathione S-transferase omega is abundant in alveolar macrophages and airway secretions, with the levels decreased in patients with chronic obstructive pulmonary disease |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Adiponectin expression by lung epithelium may modulate the inflammatory response in chronic obstructive pulmonary disease through autocrine or paracrine pathways Plasma adiponectin levels in patients with chronic obstructive pulmonary disease (COPD) were elevated and correlated with body weight loss, hyperinflation, and systemic inflammation |
Human | SLC16A4 | 9122 | solute carrier family 16, member 4 | MCT4 was reduced by 35% in vastus lateralis in chronic obstructive pulmonary disease |
Human | XDH | 7498 | xanthine dehydrogenase | XO is implicated in the exercise-induced muscle oxidative stress of COPD patients |
Human | XBP1 | 7494 | X-box binding protein 1 | Compared with COPD and donor lungs, protein levels of ER stress mediators, such as ATF-6 and ATF-4 and the apoptosis-inductor CHOP as well as XBP-1, were significantly elevated in lung homogenates and AECIIs of IPF lungs |
Human | VEGFA | 7422 | vascular endothelial growth factor A | These findings suggest the association of downregulation of bronchiolar VEGF and its receptors with cigarette smoking and COPD Title:Vascular endothelial growth factor and the risk of smoking-related COPD.|Association:Not Found|Conclusion:The 936 C/T polymorphism of the VEGF gene (including both homozygous and heterozygous) was not associated with the development of COPD (odds ratio, 1.23; 95% confidence interval, 0.760 to 1.995). Smoking is implicated as a potential cause of raised airway levels of vascular endothelial growth factor (VEGF) in the bronchitis type of chronic obstructive pulmonary disease (COPD) patients lacking alveolar destruction |
Human | SCGB1A1 | 7356 | secretoglobin, family 1A, member 1 (uteroglobin) | The genetic polymorphism in CC16 38 A/G is not associated with susceptibility to COPD in a southern Chinese population of Han nationality |
Human | TP53 | 7157 | tumor protein p53 | Title:[Development of chronic obstructive pulmonary disease correlates with mini- and microsatellite locus instability]|Association:Not Found|Conclusion:These findings suggest that rare alleles at the Hras1 locus may be associated with hereditary predisposition to COPD and the development of pneumofibrosis, while mutations in microsatellite markers result from exposure to tobacco smoke carcinogens and are not associated with the appearance of these pathologies. |