Human | DHFRL1 | 200895 | dihydrofolate reductase-like 1 | The results of this study suggest that genetic variants of methionine metabolism are associated with meningioma formation |
Human | NDRG2 | 57447 | NDRG family member 2 | Data identify NDRG2 as the first specific candidate tumor suppressor gene on chromosome 14q that is inactivated during meningioma progression |
Human | CADM1 | 23705 | cell adhesion molecule 1 | TSLC1 plays an important role in meningioma pathogenesis |
Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | genetic alterations in the methylation status of p73 or RASSF1A along with 1p LOH may result in the malignant transformation of a meningioma |
Human | YAP1 | 10413 | Yes-associated protein 1 | results represent the first demonstration that merlin regulates cell growth in meningioma cells by suppressing YAP |
Human | MSLN | 10232 | mesothelin | These findings suggest that mesothelin is expressed in at least some arachnoid and meningioma cells |
Human | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Title:Genotyping of patients with sporadic and radiation-associated meningiomas.|Association:Not Found|Conclusion:Our findings suggest that Ki-ras and ERCC2 SNPs are possible markers for meningioma formation, whereas cyclin D1 and p16 SNPs may be markers of genes that have an inverse effect on the risk to develop meningioma in irradiated and nonirradiated populations. |
Human | XRCC3 | 7517 | X-ray repair complementing defective repair in Chinese hamster cells 3 | Title:Genotyping of patients with sporadic and radiation-associated meningiomas.|Association:Not Found|Conclusion:Our findings suggest that Ki-ras and ERCC2 SNPs are possible markers for meningioma formation, whereas cyclin D1 and p16 SNPs may be markers of genes that have an inverse effect on the risk to develop meningioma in irradiated and nonirradiated populations. |
Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | Title:Genotyping of patients with sporadic and radiation-associated meningiomas.|Association:Not Found|Conclusion:Our findings suggest that Ki-ras and ERCC2 SNPs are possible markers for meningioma formation, whereas cyclin D1 and p16 SNPs may be markers of genes that have an inverse effect on the risk to develop meningioma in irradiated and nonirradiated populations. |
Human | WRN | 7486 | Werner syndrome, RecQ helicase-like | Osteosarcoma and meningioma especially |
Human | VHL | 7428 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | Germline mutation of the VHL gene and loss of heterozygosity on the VHL gene locus in 3p were detected in a meningioma in VHL disease associated with multiple cerebellar hemangioblastomas |
Human | TP73 | 7161 | tumor protein p73 | genetic alterations in the methylation status of p73 or RASSF1A along with 1p LOH may result in the malignant transformation of a meningioma |
Human | TP53 | 7157 | tumor protein p53 | study found associations of risk haplotypes and protective haplotypes in p53 for glioblastoma and in ATM for meningioma; study provides new data that could add to our understanding of brain tumour susceptibility |
Human | TGFBR2 | 7048 | transforming growth factor, beta receptor II (70/80kDa) | Title:Genotyping of patients with sporadic and radiation-associated meningiomas.|Association:Not Found|Conclusion:Our findings suggest that Ki-ras and ERCC2 SNPs are possible markers for meningioma formation, whereas cyclin D1 and p16 SNPs may be markers of genes that have an inverse effect on the risk to develop meningioma in irradiated and nonirradiated populations. |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:Genotyping of patients with sporadic and radiation-associated meningiomas.|Association:Not Found|Conclusion:Our findings suggest that Ki-ras and ERCC2 SNPs are possible markers for meningioma formation, whereas cyclin D1 and p16 SNPs may be markers of genes that have an inverse effect on the risk to develop meningioma in irradiated and nonirradiated populations. |
Human | TERT | 7015 | telomerase reverse transcriptase | Ki-67 and hTERT have roles in meningioma cell proliferation, but only hTERT has a role in disease recurrence Senescence of a Grade III derived meningioma cell line was overcome by expression of the telomerase catalytic subunit (hTERT) |
Human | SMARCB1 | 6598 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour |
Human | RFC1 | 5981 | replication factor C (activator 1) 1, 145kDa | The results of this study suggest that genetic variants of methionine metabolism are associated with meningioma formation |
Human | RB1 | 5925 | retinoblastoma 1 | These data shed more light on the molecular biology of meningioma cells and suggest that survivin and proteins of the RB pathway could play a determinant role in the development and the treatment of meningiomas |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | The majority of meningioma cases studied were positive for COX2 overexpression |
Human | PTEN | 5728 | phosphatase and tensin homolog | Title:Genotyping of patients with sporadic and radiation-associated meningiomas.|Association:Not Found|Conclusion:Our findings suggest that Ki-ras and ERCC2 SNPs are possible markers for meningioma formation, whereas cyclin D1 and p16 SNPs may be markers of genes that have an inverse effect on the risk to develop meningioma in irradiated and nonirradiated populations. |
Human | PLAUR | 5329 | plasminogen activator, urokinase receptor | Intratumoral injections of the plasmid vector expressing siRNA for uPAR resulted in regression of pre-established, subcutaneous meningioma tumors |
Human | PLAU | 5328 | plasminogen activator, urokinase | Intratumoral injections of the plasmid vector expressing siRNA for uPA resulted in regression of pre-established, subcutaneous meningioma tumors |
Human | NF2 | 4771 | neurofibromin 2 (merlin) | Title:Genotyping of patients with sporadic and radiation-associated meningiomas.|Association:Not Found|Conclusion:Our findings suggest that Ki-ras and ERCC2 SNPs are possible markers for meningioma formation, whereas cyclin D1 and p16 SNPs may be markers of genes that have an inverse effect on the risk to develop meningioma in irradiated and nonirradiated populations. There is a higher frequency of biallelic NF2 inactivation in fibroblastic (52%) versus meningothelial (18%) tumors, presence of macro-mutations on 22q also shows marked differences between fibroblastic (86%) and meningothelial (39%) meningioma subtypes results represent the first demonstration that merlin regulates cell growth in meningioma cells by suppressing YAP |
Human | MTRR | 4552 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | The MTRR A66G and GG genotypes were significantly associated with risk of meningioma but not glioma |