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Genes (10)
Species: human : 10 | |
Human | AKR1C3 | 8644 | aldo-keto reductase family 1, member C3 | Title:Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia.|Association:Not Found|Conclusion:Polymorphisms in HSD3B1, CYP19, AKR1C3 genes may be associated with an enlarged prostate in older men. These data provide insights into genes that should be examined further for their potential role in the pathogenesis of BPH. (c) 2005 Wiley-Liss, Inc. | Human | SRD5A2 | 6716 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | Title:Impact of constitutional genetic variation in androgen/oestrogen-regulating genes on age-related changes in human prostate.|Association:Not Found|Conclusion:These results suggested that common variants of the CYP17 gene are associated with prostate enlargement and therefore may increase the risk of development of BPH in this population, while infrequent variants of the aromatase gene (CYP19) could be of a protective nature. Title:A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH.|Association:Not Found|Conclusion:The process(es) in which these silent single-nucleotide polymorphisms (SNPs) influence BPH phenotypes is unknown and additional studies will be needed to assess whether these SNPs have direct functional consequences. The characterization of additional molecular factors that contribute to static and dynamic obstruction may help predict response to pharmacotherapy and serve to identify novel drug targets for the clinical management of BPH. Title:Polymorphisms in the 5alpha reductase type 2 gene and urologic measures of BPH.|Association:Not Found|Conclusion:These findings do not demonstrate consistent associations between SRD5A2 genotypes and BPH. However, they suggest that the associations of V89L polymorphisms and prostate volume should be investigated further. | Human | SRD5A1 | 6715 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | Title:A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH.|Association:Not Found|Conclusion:The process(es) in which these silent single-nucleotide polymorphisms (SNPs) influence BPH phenotypes is unknown and additional studies will be needed to assess whether these SNPs have direct functional consequences. The characterization of additional molecular factors that contribute to static and dynamic obstruction may help predict response to pharmacotherapy and serve to identify novel drug targets for the clinical management of BPH. | Human | HSD3B1 | 3283 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Title:Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia.|Association:Not Found|Conclusion:Polymorphisms in HSD3B1, CYP19, AKR1C3 genes may be associated with an enlarged prostate in older men. These data provide insights into genes that should be examined further for their potential role in the pathogenesis of BPH. (c) 2005 Wiley-Liss, Inc. | Human | CYP19A1 | 1588 | cytochrome P450, family 19, subfamily A, polypeptide 1 | Title:Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia.|Association:Not Found|Conclusion:Polymorphisms in HSD3B1, CYP19, AKR1C3 genes may be associated with an enlarged prostate in older men. These data provide insights into genes that should be examined further for their potential role in the pathogenesis of BPH. (c) 2005 Wiley-Liss, Inc. | Human | CYP17A1 | 1586 | cytochrome P450, family 17, subfamily A, polypeptide 1 | Title:Impact of constitutional genetic variation in androgen/oestrogen-regulating genes on age-related changes in human prostate.|Association:Y|Conclusion:These results suggested that common variants of the CYP17 gene are associated with prostate enlargement and therefore may increase the risk of development of BPH in this population, while infrequent variants of the aromatase gene (CYP19) could be of a protective nature. | Human | CYP3A4 | 1576 | cytochrome P450, family 3, subfamily A, polypeptide 4 | Title:CYP3A4 and VDR gene polymorphisms and the risk of prostate cancer in men with benign prostate hyperplasia.|Association:Not Found|Conclusion:While independent confirmation is required in further studies, these results provide a potential tool to assist prediction strategies for this important disease. | Human | AR | 367 | androgen receptor | Title:A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH.|Association:Not Found|Conclusion:The process(es) in which these silent single-nucleotide polymorphisms (SNPs) influence BPH phenotypes is unknown and additional studies will be needed to assess whether these SNPs have direct functional consequences. The characterization of additional molecular factors that contribute to static and dynamic obstruction may help predict response to pharmacotherapy and serve to identify novel drug targets for the clinical management of BPH. Title:Impact of constitutional genetic variation in androgen/oestrogen-regulating genes on age-related changes in human prostate.|Association:Not Found|Conclusion:These results suggested that common variants of the CYP17 gene are associated with prostate enlargement and therefore may increase the risk of development of BPH in this population, while infrequent variants of the aromatase gene (CYP19) could be of a protective nature. | Human | KLK3 | 354 | kallikrein-related peptidase 3 | Title:Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia.|Association:Not Found|Conclusion:Polymorphisms in HSD3B1, CYP19, AKR1C3 genes may be associated with an enlarged prostate in older men. These data provide insights into genes that should be examined further for their potential role in the pathogenesis of BPH. (c) 2005 Wiley-Liss, Inc. | Human | ADRA1A | 148 | adrenoceptor alpha 1A | Title:A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH.|Association:Not Found|Conclusion:The process(es) in which these silent single-nucleotide polymorphisms (SNPs) influence BPH phenotypes is unknown and additional studies will be needed to assess whether these SNPs have direct functional consequences. The characterization of additional molecular factors that contribute to static and dynamic obstruction may help predict response to pharmacotherapy and serve to identify novel drug targets for the clinical management of BPH. |
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