Human | KIF2C | 11004 | kinesin family member 2C | Elevated expression of MCAK may be associated with lymphatic invasion, lymph node metastasis, and poor prognosis in gastric cancer |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | In node-negative breast cancers CXCR4 membrane expression is prognostic and probably plays a key role in vascular invasion by cancer cells and a role in lymphatic invasion |
Human | VEGFC | 7424 | vascular endothelial growth factor C | VEGF-C has an important role in lymphatic invasion via the preexisting lymphatic vessels in the tumor margin in breast cancer, VEGF-C and VEGF-D are involved in lymphatic vessel invasion prior to lymph node metastasis, and their expression decreases after lymph node metastasis occurs |
Human | SNAI2 | 6591 | snail family zinc finger 2 | Tumors with positive Slug expression invaded deeper, had more lymph node metastasis, and had more lymphatic invasion than the tumors with negative Slug expression |
Human | PTPRZ1 | 5803 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | PTPRA and PTPRZ may have roles in gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination |
Human | PTPRA | 5786 | protein tyrosine phosphatase, receptor type, A | PTPRA and PTPRZ may have roles in gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | CCR7 and the EP2/EP4 receptor signaling pathway are down-stream targets for COX-2 to enhance the migration of breast cancer cells toward LECs and to promote lymphatic invasion |
Human | PTGER4 | 5734 | prostaglandin E receptor 4 (subtype EP4) | CCR7 and the EP2/EP4 receptor signaling pathway are down-stream targets for COX-2 to enhance the migration of breast cancer cells toward LECs and to promote lymphatic invasion |
Human | PTGER2 | 5732 | prostaglandin E receptor 2 (subtype EP2), 53kDa | CCR7 and the EP2/EP4 receptor signaling pathway are down-stream targets for COX-2 to enhance the migration of breast cancer cells toward LECs and to promote lymphatic invasion |
Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | There is an inverse correlation between nm23-H1 gene product expression and lymphatic vessel invasion in esophageal squamous cell carcinoma |
Human | MUC1 | 4582 | mucin 1, cell surface associated | Lack of MUC1 polymorphism in breast cancer is significantly related to neoplasm aggressiveness, especially lymphatic vessel invasion and lymph node metastasis |
Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | The expression level of Matrix Metalloproteinase 2 mRNA showed an increasing trend according to differentiation, lymphatic invasion and Dukes' stage in colon cancer tissues |
Human | HMOX1 | 3162 | heme oxygenase (decycling) 1 | study shows HO-1 expression rate of 41.8% in colorectal cancer & 36.8% in colon adenoma; expression associated with lower rate of lymphatic invasion & tendency of fewer lymph node metastases; patients with HO-1 expressing colon cancer had better survival |
Human | GJB2 | 2706 | gap junction protein, beta 2, 26kDa | Cx26 expression is associated with lymphatic vessel invasion, large tumor size, high histological grade, and poor prognosis in human breast cancers |
Human | FOS | 2353 | FBJ murine osteosarcoma viral oncogene homolog | A loss of c-fos expression is correlated with a more advanced stage, lymph node metastasis, lymphatic invasion and shorter survival in gastric carcinoma |
Human | FIGF | 2277 | c-fos induced growth factor (vascular endothelial growth factor D) | in breast cancer, VEGF-C and VEGF-D are involved in lymphatic vessel invasion prior to lymph node metastasis, and their expression decreases after lymph node metastasis occurs |
Human | EPOR | 2057 | erythropoietin receptor | Increased erythropoietin receptor expression is associated with advanced-stage disease, lymphovascular invasion, lymph node metastasis of endometrial carcinoma |
Human | COL7A1 | 1294 | collagen, type VII, alpha 1 | The expression of COL7A1 mrna was higher in malignant tissue and was correlated with depth of tumor invasion and lymphatic invasion in ESCC |
Human | CNN1 | 1264 | calponin 1, basic, smooth muscle | expression of vascular CNN1 in the peripheral region of colon cancer tissues was significantly reduced in association with tumor progression, lymphatic invasion, vascular invasion and recurrence |
Human | CCR7 | 1236 | chemokine (C-C motif) receptor 7 | CCR7 and the EP2/EP4 receptor signaling pathway are down-stream targets for COX-2 to enhance the migration of breast cancer cells toward LECs and to promote lymphatic invasion |
Human | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | Tumors with reduced E-cadherin expression invaded deeper, had more lymph node metastasis, and had more lymphatic invasion than the tumors with preserved E-cadherin expression Micrometastasis was significantly correlated with the depth of invasion, tumor size, operation method, Lauren classification, lymphovascular invasion and loss of E-cadherin expression in primary tumor |
Human | BCL9 | 607 | B-cell CLL/lymphoma 9 | Overexpression and altered subcellular localization of ATG16L1 protein in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis are reported |
Human | CCND1 | 595 | cyclin D1 | cyclin D1-positive tumors tend to have perineural invasion more frequently.lymph vessel invasion is another factor related to cyclin D1 reactivity of the cells |