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Details
Link-It Detail - Disease - Amyloidogenesis
Debug Stats
  • ### Total Build Time: 8 ms 10.306 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 328 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 509 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 1.112 KB
  • CONCEPT_GENES gt=4 ms Completed: 4 ms rowSize= 7.156 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.149 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
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Disease (1)
Amyloidogenesis C1706803
Definition (1)
Amyloidogenesis is the formation or growth of amyloid structures, implicated in many human diseases including Alzheimer s disease (AD), Parkinson s disease (PD), type II diabetes, and spongiform encephalopathies. In these disease states, normally soluble proteins aggregate as amyloidogenic insoluble fibrils that accumulate in affected tissues or organs.
Relationships (1)

Relation Types:
diso_​to_​phys : 1


Relationships:
isa : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHYSisaimg Inhibition of Amyloidogenesis C1708512
Genes (4)

Species:
human : 4
SpeciesGeneGeneIdGene NameEvidence
HumanTTR7276transthyretin
img GENERIF, Score=1000, Pubmed Id: 17143887, UMLKSK CUI: C1706803
img GENERIF, Score=1000, Pubmed Id: 12560553, UMLKSK CUI: C1706803
img GENERIF, Score=1000, Pubmed Id: 11478875, UMLKSK CUI: C1706803
img GENERIF, Score=1000, Pubmed Id: 12874414, UMLKSK CUI: C1706803
HumanSNCA6622synuclein, alpha (non A4 component of amyloid precursor)
img GENERIF, Score=1000, Pubmed Id: 17554782, UMLKSK CUI: C1706803
HumanFURIN5045furin (paired basic amino acid cleaving enzyme)
img GENERIF, Score=861, Pubmed Id: 14596804, UMLKSK CUI: C1706803
HumanAPP351amyloid beta (A4) precursor protein
img GENERIF, Score=861, Pubmed Id: 12079364, UMLKSK CUI: C1706803
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1706803Amyloidogenesis0self