Human | MIR21 | 406991 | microRNA 21 | The combination of assays presented here supports a role for miR-17-92 polycistron and miR-21 in the maintenance of the malignant transformation of hepatocytes |
Human | MIR17 | 406952 | microRNA 17 | The combination of assays presented here supports a role for miR-17-92 polycistron and miR-21 in the maintenance of the malignant transformation of hepatocytes |
Human | NCR3 | 259197 | natural cytotoxicity triggering receptor 3 | NKG2D, NKp30, NKp44, and NKp46 acitvation affected by ligand-negative phenotype in bone marrow-derived progenitor cells, acquisition of cell-surface ligands during myeloid differentiation, defective expression of ligands on malignant transformation |
Human | RUNDC3B | 154661 | RUN domain containing 3B | activation of Rap2-binding protein 9 (RPIP9) occurs during the malignant breast epithelial transformation and increases with progression toward an invasive phenotype |
Human | MYOCD | 93649 | myocardin | Myocardin is frequently repressed during malignant transformation, contributing to a differentiation defect |
Human | MYST1 | 84148 | | hMOF is an important component of many cellular processes and plays role the in cell malignant transformation |
Human | EAPP | 55837 | E2F-associated phosphoprotein | EAPP modulates E2F-regulated transcription, stimulates proliferation, and may be involved in the malignant transformation of cells |
Human | TRPV6 | 55503 | transient receptor potential cation channel, subfamily V, member 6 | there is growing evidence that transcriptional regulation of TRPV6 in certain tissues undergoing malignant transformation, such as prostate cancer, is linked to cancer progression--{REVIEW} |
Human | UBAP1 | 51271 | ubiquitin associated protein 1 | Decreased expression of UBAP1 protein is a possible point of dysfunction along the pathogenesis pathway for nasopharyngeal carcinoma that may contribute to malignant transformation |
Human | FOXP3 | 50943 | forkhead box P3 | Increase of functional FOXP3 in T cells in cancer patients is a response to the process of malignant transformation |
Human | RHBDD3 | 25807 | rhomboid domain containing 3 | Loss of PTAG contributes to a blunted apoptotic response and is likely to predispose cells toward malignant transformation and resistance to chemotherapeutic interventions |
Human | EPB41L3 | 23136 | erythrocyte membrane protein band 4.1-like 3 | protein 4.1B in mouse small intestine & DAL-1 in human colon showed similar distributions in normal intestinal epithelial cells; expression reduced in intestinal carcinoma; may function in preventing malignant transformation of intestinal epithelial cells |
Human | TPX2 | 22974 | TPX2, microtubule-associated | Aberrant expression of TPX2 may play important role(s) in both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer and could serve as a prognostic predictor for the disease |
Human | KLRK1 | 22914 | killer cell lectin-like receptor subfamily K, member 1 | NKG2D, NKp30, NKp44, and NKp46 acitvation affected by ligand-negative phenotype in bone marrow-derived progenitor cells, acquisition of cell-surface ligands during myeloid differentiation, defective expression of ligands on malignant transformation |
Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | genetic alterations in the methylation status of p73 or RASSF1A along with 1p LOH may result in the malignant transformation of a meningioma |
Human | UBE2C | 11065 | ubiquitin-conjugating enzyme E2C | UbcH10 is highly expressed in various human primary tumors and UbcH10 has an ability to promote cell growth and malignant transformation |
Human | NCR1 | 9437 | natural cytotoxicity triggering receptor 1 | NKG2D, NKp30, NKp44, and NKp46 acitvation affected by ligand-negative phenotype in bone marrow-derived progenitor cells, acquisition of cell-surface ligands during myeloid differentiation, defective expression of ligands on malignant transformation |
Human | NCR2 | 9436 | natural cytotoxicity triggering receptor 2 | NKG2D, NKp30, NKp44, and NKp46 acitvation affected by ligand-negative phenotype in bone marrow-derived progenitor cells, acquisition of cell-surface ligands during myeloid differentiation, defective expression of ligands on malignant transformation |
Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | High-level expression of RCAS1 is involved in the malignant transformation of endometrium, and RCAS1 coexpression with ER-alpha may be associated with development and metastasis of endometrial carcinoma |
Human | NRP1 | 8829 | neuropilin 1 | NRP-1 expression was augmented threefold during malignant transformation of ovarian epithelial cells with oncogene ras, suggesting an association between NRP-1 and oncogenesis |
Human | HMGA2 | 8091 | high mobility group AT-hook 2 | findings suggest that amplification and overexpression of HMGIC and possibly MDM2 might be important genetic events that may contribute to malignant transformation of benign pleomorphic adenoma HMGA2-dependent tumorigenesis is caused by a disturbed equilibrium in the co-expression of the HMGA2 splice variants leading to aberrant cell proliferation and/or malignant transformation of cells |
Human | SEMA3B | 7869 | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | SEMA3B gene alterations may play a important role in the malignant transformation of NSCLC via a two-hit mechanism, including epigenetic changes and allelic loss, for tumor suppressor gene inactivation |
Human | PAX8 | 7849 | paired box 8 | PAX8PPARgamma increases thyroid cell viability and has opposite effects on thyroid-specific gene expression, suggesting that the presence of this rearrangement may contribute to the malignant transformation of thyroid follicular cells |
Human | YES1 | 7525 | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | activation of the protooncogene product c-Yes may play a significant role in the malignant transformation of hepatocytes |
Human | WT1 | 7490 | Wilms tumor 1 | Data suggest that WT1 protein expression is maintained during angiogenesis and malignant transformation of endothelial cells and can be considered as a new endothelial marker |