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Genes (88)
Species: human : 88 | |
Human | TPH2 | 121278 | tryptophan hydroxylase 2 | Absence of the Arg441His polymorphism in the tryptophan hydroxylase 2 gene in adults with anxiety disorders and depression Variant is not a major determinant of genetic risk for depression in aged patients | Human | DTNBP1 | 84062 | dystrobrevin binding protein 1 | DTNBP1 haplotypes, which have been found to be risk factors for schizophrenia, are unlikely to be risk factors for anxiety and depression | Human | GAL | 51083 | galanin/GMAP prepropeptide | The involvement of galanin is reviewed in the modulation of such functions as neurotransmitter release, memory, pain, depression, anxiety, obesity, gut motility, neuroendocrine regulation, development and neuroregeneration | Human | PDE11A | 50940 | phosphodiesterase 11A | Variants in PDE11A are not associated with citalopram response in patient with depression | Human | DISC1 | 27185 | disrupted in schizophrenia 1 | Altered DISC1-PDE4B interaction may thus underlie the symptoms of some cases of schizophrenia and depression.(Review) | Human | DKK1 | 22943 | dickkopf WNT signaling pathway inhibitor 1 | Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling | Human | TPPP | 11076 | tubulin polymerization promoting protein | GSK-3 is involved in the regulation of, and cross-talk between, two major forms of synaptic plasticity, N-methyl-D-aspartate receptor dependent long-term potentiation and NMDAR-dependent long-term depression--REVIEW | Human | CLOCK | 9575 | clock circadian regulator | compared to T/T homozygotes, bipolar depressed carriers of the C allele had a similar degree of severity of depression, but showed higher activity levels in the evening, a delayed sleep onset and a reduced amount of sleep during the night | Human | BAG4 | 9530 | BCL2-associated athanogene 4 | SODD/BAG-4 is not only a silencer of TNFR1 but also a modulator of CD95 activity, regulating the balance of both death-promoting and -depressing signals | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | HMW adiponectin complex is the active form, which can depress serum glucose levels | Human | SGCE | 8910 | sarcoglycan, epsilon | Severe myoclonus-dystonia syndrome characterized by obsessive-compulsive disorder, depression, and anxiety was shown to be associated with a novel truncating mutation located within exon 4 of SGCE | Human | WFS1 | 7466 | Wolfram syndrome 1 (wolframin) | The relative risk of psychiatric hospitalization for depression was estimated to be 7.1 (95% CI 1.9-26.6) for carriers of a single wolframin mutation compared to noncarriers | Human | UCP3 | 7352 | uncoupling protein 3 (mitochondrial, proton carrier) | Depressed UCP3 expression may be an important mechanism for reducing the formation of oxygen-derived free radicals | Human | TTR | 7276 | transthyretin | Serotonergic hypofunction in depression, reflected by low CSF 5-HIAA, may result in decreased choroid plexus transthyretin production, alterations in central thyroid hormone kinetics, and increased vulnerability to suicidal ideation and perhaps suicide | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | Title:Gene-environment interaction analysis of serotonin system markers with adolescent depression.|Association:Y|Conclusion:HTR2A and TPH significantly predicted the depression group, independent of the effects of sex, environmental risk group and their interaction. In addition, there was a trend for an effect of 5HTTLPR, which was significant in female subjects. Furthermore, there was a significant genotype-environmental risk interaction for 5HTTLPR in female subjects only, with the effect being in the same direction as another recent study, reaffirming that an important source of genetic heterogeneity is exposure to environmental risk. TPH1 gene is implicated in depression Title:Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity.|Association:Not Found|Conclusion:No significant finding was observed in the overall sample as well as in the pindolol group, while TPH*A/A was associated with a slower response to fluvoxamine treatment in subjects not taking pindolol (P = 0.001). This effect was independent from the previously reported influence of 5-HTTLPR polymorphism. If confirmed, these results may shed further light on the genetically determined component of the response to pharmacological treatments, thus helping the clinician to individualize each patient's therapy according to their genetic pattern. | Human | TP53 | 7157 | tumor protein p53 | A novel isochroman derivative inhibited apoptosis in vascular endothelial cells through depressing the levels of integrin beta4 and TP53 | Human | SNCA | 6622 | synuclein, alpha (non A4 component of amyloid precursor) | suggest a novel physiological role for alpha-Syn in regulating SERT activity and may be of relevance in certain mental illnesses and in depression, in which SERT function is believed to be dysregulated | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Click here to display 51 evidence detail records. | Human | SLC6A3 | 6531 | solute carrier family 6 (neurotransmitter transporter), member 3 | Using a gene-by-environment (G x E) design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting to predict first-onset episodes of depression | Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | Monocyte chemoattractant protein-1 (MCP1) may play a role in depression | Human | PSEN1 | 5663 | presenilin 1 | expression of mutant PS1 in cultured neurons depresses synaptic transmission by causing a physical reduction in the number of synapses | Human | PRKAR2B | 5577 | protein kinase, cAMP-dependent, regulatory, type II, beta | there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta | Human | PRKACB | 5567 | protein kinase, cAMP-dependent, catalytic, beta | there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta | Human | PPP3CB | 5532 | protein phosphatase 3, catalytic subunit, beta isozyme | depressed NCX activity might contribute to the etiology of in vivo cardiac hypertrophy and dysfunction occurring under conditions in which both calcineurin and protein kinase C are chronically activated | Human | PON1 | 5444 | paraoxonase 1 | Findings suggest that the association of PON1 Q192R with symptoms of depression in the occupationally exposed to toxins that everyone in the general population is exposed to rather than to toxins used by sheep dippers or Gulf War veterans |
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