Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | association of Lp-PLA(2) levels with arterial disease events implies a role for this enzyme in atherogenesis, our findings suggest that it is not prothrombotic[Lipoprotein-associated phospholipase A2] |
Human | STARD5 | 80765 | StAR-related lipid transfer (START) domain containing 5 | The presence of StarD5 different human liver cells that are related to inflammatory processes provides new clues to its role of in free sterol transport in the cells and in lipid-mediated atherogenesis |
Human | GPBP1 | 65056 | GC-rich promoter binding protein 1 | Vasculin is a novel vascular protein differentially expressed in human atherogenesis |
Human | CXCL16 | 58191 | chemokine (C-X-C motif) ligand 16 | Soluble CXCL16 could be linked to atherogenesis not only as a marker of inflammation, but also as a potential inflammatory mediator |
Human | RETN | 56729 | resistin | resistin -420C>G polymorphism may be potentially involved in the inflammatory component of atherogenesis through an enhanced production of C-reactive protein |
Human | TLR9 | 54106 | toll-like receptor 9 | Data indicate that the two TLR-9 promotor polymorphisms are not involved in atherogenesis |
Human | F11R | 50848 | F11 receptor | functional contribution of JAM-A to atherogenesis |
Human | KLF2 | 10365 | Kruppel-like factor 2 (lung) | up-regulation of CD59 via ERK5/KLF2 activation leads to endothelial resistance to complement-mediated injury and protects from atherogenesis in regions of laminar shear stress |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Studies published indicate that polymorphisms at the adiponectin locus are predictors of circulating adiponectin levels, insulin sensitivity, and atherosclerosis, having a pivotal role of this adipokine in the modulation of metabolism and atherogenesis review: low levels of adiponectin associated with obesity favors the recruitment of T lymphocytes, which are key contributors to adaptive immune response during atherogenesis low levels of adiponectin associated with obesity, the metabolic syndrome, and diabetes favor T-lymphocyte recruitment and contribute to adaptive immune response during atherogenesis |
Human | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | Based on their role in atherogenesis, this enhanced expression of RANKL and RANK could contribute to the increased risk of cardiovascular disease in hyperhomocystinemia |
Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | Based on their role in atherogenesis, this enhanced expression of RANKL and RANK could contribute to the increased risk of cardiovascular disease in hyperhomocystinemia |
Human | NR4A3 | 8013 | nuclear receptor subfamily 4, group A, member 3 | Nur77, Nurr1, and NOR-1 are expressed in human atherosclerotic lesion macrophages and reduce human macrophage lipid loading and inflammatory responses, providing further evidence for a protective role of these factors in atherogenesis |
Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | If Lp-PLA(2) independently influences clinical events, it does so by promoting atherosclerotic plaque instability rather than by stimulating atherogenesis |
Human | RAB7A | 7879 | RAB7A, member RAS oncogene family | may be involved in the process of atherogenesis |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | By activating CXCR4, macrophage migration inhibitory factordisplays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis |
Human | VTN | 7448 | vitronectin | Plasma vitronectin level potentially represents a pathogenic factor for atherogenesis and thrombus formation in patients with coronary artery disease |
Human | UCP2 | 7351 | uncoupling protein 2 (mitochondrial, proton carrier) | Our results suggest a role of UCP2 in atherogenesis |
Human | CX3CL1 | 6376 | chemokine (C-X3-C motif) ligand 1 | CX3CL1/CX3CR1 dyad may contribute to atherogenesis and plaque destabilization in human coronary artery disease |
Human | CCL7 | 6354 | chemokine (C-C motif) ligand 7 | These results suggest that oxLDL delivers its signal for MCP-3 expression via PPARgamma, which may be further related to the atherogenesis |
Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | role of inflammation also in the early stages of atherogenesis possibly involving monocyte-derived RANTES as an important mediator |
Human | S100A9 | 6280 | S100 calcium binding protein A9 | S100A8 and S100A9 in atherosclerotic plaque and calcifying matrix vesicles may significantly influence redox- and Ca2+-dependent processes during atherogenesis |
Human | S100A8 | 6279 | S100 calcium binding protein A8 | S100A8 and S100A9 in atherosclerotic plaque and calcifying matrix vesicles may significantly influence redox- and Ca2+-dependent processes during atherogenesis |
Human | PTGER4 | 5734 | prostaglandin E receptor 4 (subtype EP4) | endogenous PGE(2) may modulate inflammation during atherogenesis and other inflammatory diseases by suppressing macrophage-derived chemokine production via the EP4 receptor |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | In atherogenesis, oxidized lipid-driven activation of macrophage PPARgamma in the intima may result in a proadhesive chemokine receptor switch-CCR2 off |
Human | PON2 | 5445 | paraoxonase 2 | PON2 stimulation may represent a compensatory mechanism against the increase in cellular superoxide anion production and atherogenesis |