Human | LOC100507436 | 100507436 | | MICA is released as a soluble form from the cell surface of tumor cells and can be detected at high levels in sera of patients with gastrointestinal malignancies |
Human | CD24 | 100133941 | CD24 molecule | As a putative new oncogene that is overexpressed in gastrointestinal malignancies early in the carcinogenesis process, CD24 my be a potential target for early intervention in the prevention and treatment of cancer |
Human | GSDMB | 55876 | gasdermin B | GSDML may be a secretory or metabolic product involved in a secretory pathway, and changes in the regulation of GSDML splicing variant transcription and translation may be seen in the development and/or progression of gastrointestinal and hepatic cancers |
Human | ITLN1 | 55600 | intelectin 1 (galactofuranose binding) | Intelectin is consistently and highly overexpressed in a proportion of mesothelioma and gastrointestinal malignancies at the protein level |
Human | EML4 | 27436 | echinoderm microtubule associated protein like 4 | EML4-ALK fusion transcript is not present in gastrointestinal or breast cancers and is specific to NSCLC |
Human | DKK2 | 27123 | dickkopf WNT signaling pathway inhibitor 2 | Down-regulation of the Dkks associated to promoter hypermethylation appears to be frequently involved in gastrointestinal tumorigenesis |
Human | CLCA4 | 22802 | chloride channel accessory 4 | CLCA1 and CLCA4 may have roles as modulators of the gastrointestinal basic defect in cystic fibrosis |
Human | B3GNT2 | 10678 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | beta 3Gal-T5 plays a relevant role in gastrointestinal and pancreatic tissues counteracting the glycosylation pattern associated with malignancy |
Human | SOCS1 | 8651 | suppressor of cytokine signaling 1 | Although the methylation frequency of SOCS-1 is low, the data of Fujitake et al. indicate role of JAK/STAT/SOCS pathway in gastrointestinal tumorigenesis |
Human | VEGFA | 7422 | vascular endothelial growth factor A | VEGF levels in blood could play a role as an angiogenic marker of malignant gastrointestinal transformation |
Human | TLR5 | 7100 | toll-like receptor 5 | The interaction of TLR5 with S. typhimurium fliC in the initiation of the inflammatory and apoptotic response of gastrointestinal epithelial cells is reported |
Human | TLR2 | 7097 | toll-like receptor 2 | dominant innate immune receptor for recognition of gastrointestinal Helicobacter species |
Human | TFF1 | 7031 | trefoil factor 1 | The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis |
Human | SHH | 6469 | sonic hedgehog | Dignaling is clearly upregulated in gastrointestinal neuroendocrine carcinomas in a Gli1-dependent manner |
Human | RPL13 | 6137 | ribosomal protein L13 | Ribosomal protein L13 plays an essential role in the progression of some gastrointestinal malignancies |
Human | RAF1 | 5894 | v-raf-1 murine leukemia viral oncogene homolog 1 | Activation of the ras/raf-1 signal transduction pathway leads to prominent phenotypic changes that resemble differentiation of gastrointestinal carcinoid cells in vitro |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | There is a correlation between the genetic expression of PPARgamma from gastrointestinal tissue and body mass index, with increasing obesity correlating with a decrease in PPARgamma expression |
Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | Detection of P-glycoprotein and metallothionein seems to add certain prognostic value in gastrointestinal stromal neoplasms (MT) or gastrointestinal leiomyosarcomas (P-GP) |
Human | PDGFRA | 5156 | platelet-derived growth factor receptor, alpha polypeptide | Multiple gastrointestinal stromal and other tumors may be caused by germline PDGFRA gene mutations (V561D |
Human | MLH1 | 4292 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | This work availably evaluated the functional consequences of some missense mutations not previously determined in the hMLH1 gene and might be useful for the clinical diagnosis of hereditary gastrointestinal cancer, especially in East Asians |
Human | MBL2 | 4153 | mannose-binding lectin (protein C) 2, soluble | mbl2 gene expression may be relevant in local immune defense, particularly in restricted areas of the gastrointestinal and reproductive tracts |
Human | KIT | 3815 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumors Kit mutatation is associated with gastrointestinal mesenchymal tumors gain-of-function mutation in exon 11 of the c-kit gene is an important prognostic factor for gastrointestinal mesenchymal tumors, including myogenic and neurogenic tumors as well as GISTs |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | Data show that serum IL-6 values correlate significantly with IL-6-174 genotypes in nonfunctioning pancreatic neuroendocrine tumors (PETs) and gastrointestinal NETs (p<0.05), but not in functioning PETs |
Human | IGH@ | 3492 | | among gastrointestinal MALT lymphomas, t(14;18)-(IgH;Bcl-2) translocation clusters in hepatitis C-positive patients sustaining the role of HCV infection in the lymphoma development |
Human | HLA-G | 3135 | | review focuses on the role of HLA-G in inflammatory conditions of the bowel, which can serve as an initiator of neoplastic alterations, and examines HLA-G expression and function in a variety of gastrointestinal malignancies [review] |