Genes (68)
Species: human : 67 mouse : 1 | |
Mouse | SAT1 | 6303 | spermidine/spermine N1-acetyltransferase 1 | The finding that deletion of SSAT reduces tumorigenesis suggests that small-molecule inhibition of the enzyme may represent a nontoxic prevention and/or treatment strategy for gastrointestinal cancers. | Human | B4GALNT2 | 124872 | beta-1,4-N-acetyl-galactosaminyl transferase 2 | Introduction of sda carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis. In conclusion, a segment of the cDNA for betal,4GalNAcT which determines expression of the Sda carbohydrate structure was obtained, and reduced transcription of this beta 1,4GalNAcT resulted in the disappearance of the Sda epitope in gastrointestinal cancer. | Human | DCD | 117159 | dermcidin | We report the expression of PIF in gastrointestinal cancers, and a correlation between PIF expression in tumours, its detection in urine and weight-loss. | Human | DYNLRB1 | 83658 | dynein, light chain, roadblock-type 1 | Bombesin-like peptides (BLP) and their receptors are widely distributed throughout the intestine and are potential mitogens for gastrointestinal cancers. | Human | XAF1 | 54739 | XIAP associated factor 1 | The expression of XAF1 and HSF1 was negatively correlated in gastrointestinal cancer cell lines. XAF1 expression was lower in gastrointestinal cancers than in normal tissues with the mechanism unclear. | Human | CPSF3 | 51692 | cleavage and polyadenylation specific factor 3, 73kDa | To identify CTL-directed antigens in gastrointestinal cancer, we have investigated antigens recognized by the HLA-A2-restricted CTL line established from T cells infiltrating into colon cancer and report herein cleavage and polyadenylation specificity factor (CPSF) as a potent antigen holding peptides capable of inducing CTLs. Five peptides at amino acid positions 250-258, 392-400, 534-542, 1296-1304 and 1359-1368 of CPSF, which were recognized by the CTL line, were found to have the ability to induce HLA-A2-restricted and tumor-specific CTLs in peripheral blood mononuclear cells of the majority (69%, 11/16) of gastrointestinal cancer patients with different HLA-A2 subtypes. | Human | CPSF1 | 29894 | cleavage and polyadenylation specific factor 1, 160kDa | Cleavage and polyadenylation specificity factor (CPSF)-derived peptides can induce HLA-A2-restricted and tumor-specific CTLs in the majority of gastrointestinal cancer patients. To identify CTL-directed antigens in gastrointestinal cancer, we have investigated antigens recognized by the HLA-A2-restricted CTL line established from T cells infiltrating into colon cancer and report herein cleavage and polyadenylation specificity factor (CPSF) as a potent antigen holding peptides capable of inducing CTLs. | Human | TXNIP | 10628 | thioredoxin interacting protein | Vitamin D3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and its relation to stage of disease. We employed TaqMan RT-PCR assay to investigate VDUP1 expression in surgical specimens of primary tumors and their adjacent normal tissues from gastrointestinal cancer patients, 40 with colorectal and 12 with gastric cancers. These results suggest a possible role of VDUP1 in the pathogenesis of gastrointestinal cancer, as well as its clinical significance. | Human | GPA33 | 10223 | glycoprotein A33 (transmembrane) | Organ-specific expression of the intestinal epithelium-related antigen A33, a cell surface target for antibody-based imaging and treatment in gastrointestinal cancer. A33 is the first example of a constitutively expressed, organ-specific epithelial membrane antigen permitting highly specific tumor targeting in patients with gastrointestinal cancer. The A33 cognate antigen is a promising target for immunotherapy of gastrointestinal cancers. | Human | RAD50 | 10111 | RAD50 homolog (S. cerevisiae) | Frameshift mutations at coding mononucleotide repeats of the hRAD50 gene in gastrointestinal carcinomas with microsatellite instability. | Human | BAG3 | 9531 | BCL2-associated athanogene 3 | When BAG-3 mRNA was analyzed in other gastrointestinal cancers (hepatocellular carcinoma; esophageal, stomach and colon cancer), no difference was found from their corresponding normal controls. | Human | BAG4 | 9530 | BCL2-associated athanogene 4 | In contrast, SODD mRNA levels were not different (P > 0.05) in four other gastrointestinal cancers (liver, esophagus, stomach, colon) compared with the corresponding normal tissues. | Human | BCL10 | 8915 | B-cell CLL/lymphoma 10 | Frameshift mutations in Fas, Apaf-1, and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype. | Human | EIF2S2 | 8894 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas. | Human | ZNF148 | 7707 | zinc finger protein 148 | ZBP-89 protein is elevated in a variety of gastrointestinal cancers as well as the pancreas. | Human | UGT1A | 7361 | UDP glucuronosyltransferase 1 family, polypeptide A complex locus | In conclusion, induction of gastrointestinal UGT enzyme activities after consumption of dietary anticarcinogens may contribute to a better detoxification of potentially carcinogenic compounds and subsequently to the prevention of gastrointestinal cancer. | Human | TXN | 7295 | thioredoxin | Surgical stress during operation for gastrointestinal cancer increases plasma thioredoxin levels and decreases mitochondrial membrane potential in peripheral blood lymphocytes. In the present study, we examined plasma levels of TRX in cases undergoing operations for gastrointestinal cancer. | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | Studies on the expression of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in various human cancer tissues have further demonstrated that activation of proMMP-2 mediated by a combination of TIMP-2 and MT1-MMP (the proMMP-2/TIMP-2/MT1-MMP system) correlates well with the progression of most of these cancers such as the breast carcinomas, thyroid papillary carcinomas, gastric adenocarcinomas, oral squamous cell carcinomas and gliomas, whereas MMP-7 plays an important role in the metastases of endometrial and gastrointestinal carcinomas. | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | In the present study, to clarify the significance of CRTF in gastrointestinal cancers we measured the binding activity of CRTF to HTE using an electrophoretic mobility shift assay (EMSA), and the TIMP-1 concentration by ELISA after various stimulation of six cancer cell lines (KE-3, TE-9, MKN-28, MKN-45, KM12SM, SW620). These results suggested that IL-I0, and unknown factors in addition to IL-10, induced TIMP-1 synthesis via an increase in the binding activity of CRTF in gastrointestinal cancers, and that interaction between cancer cells and fibroblasts may play an important role in TIMP-1 synthesis through a signal transduction pathway consisting of CRTF phosphorylation and HTE activation. Significance of cysteine rich transcription factor (CRTF) in the synthesis of tissue inhibitor of metalloproteinases 1 (TIMP-1) in gastrointestinal cancers. | Human | TFF2 | 7032 | trefoil factor 2 | TFF1, TFF2 and TFF3 proteins might be applicable for chemoprevention of gastrointestinal cancer associated with chronic persistent inflammation. | Human | TFF1 | 7031 | trefoil factor 1 | TFF1, TFF2 and TFF3 proteins might be applicable for chemoprevention of gastrointestinal cancer associated with chronic persistent inflammation. | Human | TCF7L2 | 6934 | transcription factor 7-like 2 (T-cell specific, HMG-box) | Genetic alterations in the human Tcf-4 gene in Japanese patients with sporadic gastrointestinal cancers with microsatellite instability. | Human | TCF4 | 6925 | transcription factor 4 | Genetic alterations in the human Tcf-4 gene in Japanese patients with sporadic gastrointestinal cancers with microsatellite instability. | Human | STK11 | 6794 | serine/threonine kinase 11 | Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal recessive colorectal tumors; STK11 mutations and Peutz-Jeghers syndrome; TGFbeta and gastrointestinal cancer; BMPR1A mutations and juvenile polyposis; FGF/FGFR alterations in gastrointestinal neoplasms; PTCH mutations and gastrointestinal neoplasms; RUNX3 expression and gastric cancer; role of mucins in gastric carcinogenesis; KIT, PDGFRalpha, and gastrointestinal stromal tumors; intestinal neurofibromatosis; and gastrointestinal tumors in other disorders. Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability. These findings suggest that STK11 is a tumor suppressor gene regulating the development of hamartomas, and that somatic mutation of p53 subsequently promotes gastrointestinal cancer at a later stage in PJS. | Human | SPINK1 | 6690 | serine peptidase inhibitor, Kazal type 1 | Tumor-associated trypsin inhibitor, TATI, in gastrointestinal cancer and related benign diseases. |
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