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Details
Link-It Detail - Disease - Brain Edema
Debug Stats
  • ### Total Build Time: 197 ms 38.258 KB
  • CONCEPT_NAME gt=10 ms Completed: 10 ms rowSize= 320 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 710 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=11 ms Completed: 11 ms rowSize= 550 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.516 KB
  • CONCEPT_RELATIONSHIPS gt=145 ms Completed: 145 ms rowSize= 13.915 KB
  • CONCEPT_GENES gt=23 ms Completed: 23 ms rowSize= 19.920 KB
  • CONCEPT_XREFS gt=8 ms Completed: 8 ms rowSize= 1.146 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Brain Edema C1527311
Definition (1)
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Semantic Types (1)
Pathologic Function (T046)
Parents (1)
img Brain Diseases C0006111
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076824img Brain Diseases C0006111
Relationships (152)

Relation Types:
diso_​to_​anat : 13
diso_​to_​chem : 62
diso_​to_​diso : 70
diso_​to_​phen : 2
diso_​to_​phys : 5


Relationships:
none : 104
associated_​with : 1
location_​of : 1
mapped_​to : 2
may_​treat : 43
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 7
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO109img Brain Injuries C0270611
DISO_to_DISO96img Brain Injuries C0270611
DISO_to_ANAT94img Brain C0006104
DISO_to_ANAT91img Brain C0006104
DISO_to_DISO75img Cerebral Hemorrhage C2937358
DISO_to_ANAT73img Blood - brain barrier anatomy C0005854
DISO_to_DISO69img Complication Aspects C1171258
DISO_to_DISO66img chemically induced C0007994
DISO_to_DISO62img Brain Ischemia C0007786
DISO_to_CHEM61img Aquaporin 4 C0292777
DISO_to_DISO56img Complication Aspects C1171258
DISO_to_DISO53img Brain Ischemia C0007786
DISO_to_DISO53img Brain Neoplasms C0006118
DISO_to_DISO52img chemically induced C0007994
DISO_to_DISO51img Brain Neoplasms C0006118
DISO_to_DISO50img Cerebral Hemorrhage C2937358
DISO_to_ANAT46img Blood - brain barrier anatomy C0005854
DISO_to_DISO42img Diabetic Ketoacidosis C0011880
DISO_to_DISO41img Intracranial Hypertension C0151740
DISO_to_DISO40img Cerebrovascular accident C0038454
DISO_to_DISO40img Diabetic Ketoacidosis C0011880
DISO_to_DISO39img Intracranial Hypertension C0151740
DISO_to_DISO36img Meningioma C0025286
DISO_to_CHEM34img Neuroprotective Agents C0242912
DISO_to_DISO33img Infarction, Middle Cerebral Artery C0740392
Genes (19)

Species:
human : 19
SpeciesGeneGeneIdGene NameEvidence
HumanNDUFAF291942NADH dehydrogenase (ubiquinone) complex I, assembly factor 2
img OMIM, Score=1000, UMLKSK CUI: C1527311
HumanC20orf779133
img OMIM, Score=1000, UMLKSK CUI: C1527311
HumanNDUFAF429078NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
img OMIM, Score=1000, UMLKSK CUI: C1527311
HumanSLC7A1123657solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
img GENERIF, Score=1000, Pubmed Id: 18469825, UMLKSK CUI: C1527311
HumanVEGFA7422vascular endothelial growth factor A
img GENERIF, Score=901, Pubmed Id: 18317686, UMLKSK CUI: C1527311
img GENERIF, Score=901, Pubmed Id: 12425822, UMLKSK CUI: C1527311
HumanNPPB4879natriuretic peptide B
img GENERIF, Score=1000, Pubmed Id: 18219371, UMLKSK CUI: C1527311
HumanNDUFS64726NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
img OMIM, Score=1000, UMLKSK CUI: C1527311
HumanNDUFS44724NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
img OMIM, Score=1000, UMLKSK CUI: C1527311
HumanNDUFV14723NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
img OMIM, Score=1000, UMLKSK CUI: C1527311
HumanNDUFS24720NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
img OMIM, Score=1000, UMLKSK CUI: C1527311
HumanNDUFS14719NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
img OMIM, Score=1000, UMLKSK CUI: C1527311
HumanNDUFA14694NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
img OMIM, Score=1000, UMLKSK CUI: C1527311
HumanIL1RN3557interleukin 1 receptor antagonist
img GENERIF, Score=734, Pubmed Id: 14753487, UMLKSK CUI: C1527311
HumanEDN11906endothelin 1
img GENERIF, Score=901, Pubmed Id: 18436890, UMLKSK CUI: C1527311
HumanCRP1401C-reactive protein, pentraxin-related
img GENERIF, Score=1000, Pubmed Id: 18219371, UMLKSK CUI: C1527311
HumanCPT21376carnitine palmitoyltransferase 2
img GENERIF, Score=1000, Pubmed Id: 18306170, UMLKSK CUI: C1527311
HumanATP1A2477ATPase, Na+/K+ transporting, alpha 2 polypeptide
img OMIM, Score=882, UMLKSK CUI: C1527311
HumanAQP4361aquaporin 4
img GENERIF, Score=734, Pubmed Id: 18309154, UMLKSK CUI: C1527311
img GENERIF, Score=901, Pubmed Id: 17890008, UMLKSK CUI: C1527311
HumanAGER177advanced glycosylation end product-specific receptor
img GENERIF, Score=1000, Pubmed Id: 18775683, UMLKSK CUI: C1527311
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1527311Brain Edema0self