Human | PINK1 | 65018 | PTEN induced putative kinase 1 | PINK1 deficiency in humans results in mitochondrial abnormalities associated with cellular stress, a pathological phenotype, which can be ameliorated by enhanced expression of parkin |
Human | RETN | 56729 | resistin | data implicate resistin in the pathophysiology of the human insulin resistance syndrome, an effect mediated by the -180C>G promoter SNP and potentially cellular oxidative stress |
Human | UGT1A1 | 54658 | UDP glucuronosyltransferase 1 family, polypeptide A1 | Nrf2-Keap1-dependent UGT1A1 induction by prooxidants might represent a key adaptive response to cellular oxidative stress |
Human | PPP1R15A | 23645 | protein phosphatase 1, regulatory subunit 15A | During conditions of cell stress, GADD34 forms a stable complex with tuberous sclerosis complex (TSC) 1/2, causes TSC2 dephosphorylation, and inhibits signaling by mammalian target of the rapamycin (mTOR) |
Human | SIRT3 | 23410 | sirtuin 3 | Using a highly specific antibody against the N terminus of SirT3, we found that SirT3 is transported from the nucleus to the mitochondria upon cellular stress |
Human | TAB2 | 23118 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop; TAB1 and TAB2 were differentially involved in the phosphorylation of TAK1 |
Human | COPS5 | 10987 | COP9 signalosome subunit 5 | The S100A7-Jab1 pathway acts to enhance survival under conditions of cellular stress, such as anoikis, which may promote progression of breast cancer |
Human | HTATIP2 | 10553 | HIV-1 Tat interactive protein 2, 30kDa | results suggest that TIP30 is involved in cellular oxidative stress surveillance and induces apoptosis through stabilization of p53 mRNA in hepatocellular carcinoma cells |
Human | TAB1 | 10454 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 | characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop; TAB1 and TAB2 were differentially involved in the phosphorylation of TAK1 |
Human | KEAP1 | 9817 | kelch-like ECH-associated protein 1 | Nrf2-Keap1-dependent UGT1A1 induction by prooxidants might represent a key adaptive response to cellular oxidative stress |
Human | TRAF4 | 9618 | TNF receptor-associated factor 4 | TRAF4 may play a role in p53-mediated proapoptotic signaling in the response to cellular stress |
Human | ALDH4A1 | 8659 | aldehyde dehydrogenase 4 family, member A1 | ALDH4 is a p53-inducible gene with a protective role in cellular stresses |
Human | VCP | 7415 | valosin containing protein | valosin-containing protein (VCP) is an integral component of the endoplasmic reticulum associated degradation and cellular stress pathways induced by the unfolded protein response, which destroys the CFTR to cause cystic fibrosis |
Human | UCP2 | 7351 | uncoupling protein 2 (mitochondrial, proton carrier) | Mitochondrial UCPs precondition neurons by dissociating cellular energy production from that of free radicals to withstand the harmful effects of cellular stress occurring in a variety of neurodegenerative disorders, including epilepsy |
Human | UBE2V2 | 7336 | ubiquitin-conjugating enzyme E2 variant 2 | Ubc13-Mms2 and Lys63-polyubiquitin chains are associated with signaling cellular stress |
Human | UBE2N | 7334 | ubiquitin-conjugating enzyme E2N | Ubc13-Mms2 and Lys63-polyubiquitin chains are associated with signaling cellular stress |
Human | TP53 | 7157 | tumor protein p53 | These data indicate a novel p53-dependent mechanism in which cell stress mobilizes nucleolin for transient replication inhibition and DNA repair pivotal role of NO in the induction of cellular stress and the activation of a p53 response pathway during chronic inflammation stabilization of p53 mRNA in hepatocellular carcinoma cells is involved in TIP30 control of cellular oxidative stress and apoptosis induction |
Human | TNF | 7124 | tumor necrosis factor | Endogenous tumor necrosis factor promotes resistance to cellular stresses by inducing the metallothionein-1A gene |
Human | MAP3K7 | 6885 | mitogen-activated protein kinase kinase kinase 7 | characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop; TAB1 and TAB2 were differentially involved in the phosphorylation of TAK1 |
Human | RB1 | 5925 | retinoblastoma 1 | Expression of RB C pocket fragments in HSF induces delayed cell cycle progression and sensitizes to apoptosis upon cellular stresses |
Human | RAN | 5901 | RAN, member RAS oncogene family | Findings indicate that the decrease in ATP levels induced by cellular stress causes a decrease in RanGTP levels and a collapse of Ran distribution in the cytoplasmic and nuclear compartments |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | under specific conditions of cellular stress, a common variation in cyclooxygenase-2 promoter structure may enhance cyclooxygenase-2 transcription, and this may contribute to the proliferation of an inflammatory response in brain cells |
Human | PRNP | 5621 | prion protein | Cellular stress up-regulates both the transcription and translation of PrP through interaction with the HSEs on the PrP gene promoter, resulting in an increase in protein synthesis physiological level of endogenous PrPC plays a protective role against staurosporine-mediated cellular stress |
Human | PPP1R10 | 5514 | protein phosphatase 1, regulatory subunit 10 | Findings suggest that PNUTS may play an important role in controlling cell death in response to cellular stresses such as hypoxia through the post-translational modification of p53 and MDM2 |
Human | PIP4K2A | 5305 | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a |