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Details
Link-It Detail - Disease - Primary Glioblastoma
Debug Stats
  • ### Total Build Time: 111 ms 44.482 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 338 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 457 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=68 ms Completed: 68 ms rowSize= 15.240 KB
  • CONCEPT_GENES gt=33 ms Completed: 33 ms rowSize= 27.241 KB
  • CONCEPT_XREFS gt=6 ms Completed: 6 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Primary Glioblastoma C1514422
Definition (1)
A glioblastoma arising de novo, with no prior evidence of lower grade astrocytoma. It occurs mostly in older patients and is associated with specific molecular abnormalities, notably epidermal growth factor receptor (EGFR) overexpression and also mouse double minute 2 (MDM2) gene amplification. -- 2004
Relationships (39)

Relation Types:
diso_​to_​anat : 17
diso_​to_​diso : 21
diso_​to_​phen : 1


Relationships:
is_​abnormal_​cell_​of_​disease : 7
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 7
is_​normal_​cell_​origin_​of_​disease : 4
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​finding_​of_​disease : 3
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 1
may_​be_​abnormal_​cell_​of_​disease : 2
may_​be_​cytogenetic_​abnormality_​of_​disease : 5
may_​be_​finding_​of_​disease : 3
may_​be_​molecular_​abnormality_​of_​disease : 3
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Astrocytes C0004112
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Cell, Neuroepithelial C1449624
DISO_to_ANATis_associated_anatomic_site_ofimg Central Nervous System C0927232
DISO_to_ANATmay_be_abnormal_cell_of_diseaseimg Fibrillary Neoplastic Astrocyte C1517170
DISO_to_ANATmay_be_abnormal_cell_of_diseaseimg Gemistocyte C0333735
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Astrocyte C1513925
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Glial Cell C1513978
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Neuroepithelial Cell C1514048
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell C1514049
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Nerve Cell, Neuroepithelial Cell, and Supporting Cell of the Nervous System C1518293
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths C1518250
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Nervous System C0027763
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Neuroepithelial Tissue C1518281
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Neuroglia C0027836
DISO_to_ANATis_abnormal_cell_of_diseaseimg Poorly Differentiated Neoplastic Astrocyte C1514224
DISO_to_DISOis_finding_of_diseaseimg Anaplasia C0002793
DISO_to_DISOisaimg Brain Stem Glioblastoma C1332610
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg EGFR Gene Activation C1512116
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg EGFR Protein Overexpression C1512117
DISO_to_DISOmay_be_cytogenetic_abnormality_of_diseaseimg Gain of Chromosome 7q C1517420
DISO_to_DISOmay_be_finding_of_diseaseimg Headache C0018681
DISO_to_DISOis_not_finding_of_diseaseimg Indolent Clinical Course C1334168
DISO_to_DISOis_finding_of_diseaseimg Infiltrative Growth C1512752
Genes (23)

Species:
human : 23
SpeciesGeneGeneIdGene NameEvidence
HumanCITED4163732Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
img GENERIF, Score=884, Pubmed Id: 18722883, UMLKSK CUI: C1514422
HumanTHEM4117145thioesterase superfamily member 4
img NCI, Score=801, Pubmed Id: 15026474, UMLKSK CUI: C1514422
HumanAGAP2116986ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
img GENERIF, Score=983, Pubmed Id: 16150119, UMLKSK CUI: C1514422
img NCI, Score=801, Pubmed Id: 16150119, UMLKSK CUI: C1514422
HumanMARK457787MAP/microtubule affinity-regulating kinase 4
img NCI, Score=801, Pubmed Id: 12735302, UMLKSK CUI: C1514422
HumanNDRG257447NDRG family member 2
img GENERIF, Score=983, Pubmed Id: 18709645, UMLKSK CUI: C1514422
HumanDKK327122dickkopf WNT signaling pathway inhibitor 3
img NCI, Score=801, Pubmed Id: 9070656, UMLKSK CUI: C1514422
HumanCHEK211200checkpoint kinase 2
img GENERIF, Score=1000, Pubmed Id: 16078115, UMLKSK CUI: C1514422
img NCI, Score=801, Pubmed Id: 16078115, UMLKSK CUI: C1514422
HumanHRK8739harakiri, BCL2 interacting protein (contains only BH3 domain)
img NCI, Score=801, Pubmed Id: 16155764, UMLKSK CUI: C1514422
HumanCXCR47852chemokine (C-X-C motif) receptor 4
img NCI, Score=801, Pubmed Id: 9808513, UMLKSK CUI: C1514422
HumanVIM7431vimentin
img GENERIF, Score=901, Pubmed Id: 12084347, UMLKSK CUI: C1514422
HumanUNG7374uracil-DNA glycosylase
img NCI, Score=801, Pubmed Id: 9852992, UMLKSK CUI: C1514422
HumanTP537157tumor protein p53
img GENERIF, Score=1000, Pubmed Id: 15756520, UMLKSK CUI: C1514422
HumanPRKCA5578protein kinase C, alpha
img NCI, Score=801, Pubmed Id: 8700129, UMLKSK CUI: C1514422
HumanPIK3CA5290phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
img GENERIF, Score=983, Pubmed Id: 16150119, UMLKSK CUI: C1514422
HumanOSM5008oncostatin M
img NCI, Score=801, Pubmed Id: 16206166, UMLKSK CUI: C1514422
img NCI, Score=801, Pubmed Id: 16206166, UMLKSK CUI: C1514422
HumanMGMT4255O-6-methylguanine-DNA methyltransferase
img GENERIF, Score=983, Pubmed Id: 19100509, UMLKSK CUI: C1514422
HumanITGAV3685integrin, alpha V
img GENERIF, Score=983, Pubmed Id: 18394009, UMLKSK CUI: C1514422
HumanIGF1R3480insulin-like growth factor 1 receptor
img GENERIF, Score=708, Pubmed Id: 11782378, UMLKSK CUI: C1514422
HumanGPR262849G protein-coupled receptor 26
img GENERIF, Score=1000, Pubmed Id: 18037267, UMLKSK CUI: C1514422
HumanGFAP2670glial fibrillary acidic protein
img GENERIF, Score=901, Pubmed Id: 12084347, UMLKSK CUI: C1514422
HumanEPHA21969EPH receptor A2
img NCI, Score=801, Pubmed Id: 16207473, UMLKSK CUI: C1514422
HumanCCND3896cyclin D3
img NCI, Score=801, Pubmed Id: 10416984, UMLKSK CUI: C1514422
HumanBIRC5332baculoviral IAP repeat containing 5
img GENERIF, Score=983, Pubmed Id: 12073047, UMLKSK CUI: C1514422
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1514422Primary Glioblastoma0self