Human | CITED4 | 163732 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | mutational study of CITED4 in 24 glial tumors (22 primary glioblastomas, 1 low-grade astrocytoma & its recurrent secondary glioblastoma) |
Human | THEM4 | 117145 | thioesterase superfamily member 4 | Because loss of CTMP function and/or expression may remove the inhibitory effects on Akt and promote tumorigenesis, we studied 93 primary glioblastomas and nine glioblastoma cell lines for CTMP deletion, mutation, promoter hypermethylation, and mRNA expression. |
Human | AGAP2 | 116986 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | Here, we investigated two further Pi3k/Akt pathway genes, namely PIK3CA (3q26.3) and phosphatidylinositol-3-kinase enhancer (PIKE) (CENTG1, 12q14), for genetic alteration and aberrant expression in a series of 97 primary glioblastomas. an important role of PIKE gene aberrations in the molecular pathogenesis of primary glioblastomas |
Human | MARK4 | 57787 | MAP/microtubule affinity-regulating kinase 4 | Following our previous studies on structural 19q chromosome rearrangements in gliomas, we have undertaken a detailed FISH analysis of the breakpoints and identified a 19q13.2 intrachromosomal amplification of the MAP/microtubule affinity-regulating kinase 4 (MARK4) gene in three primary glioblastoma cell lines. |
Human | NDRG2 | 57447 | NDRG family member 2 | NDRG2 as a candidate tumor suppressor gene that is epigenetically silenced in the majority of primary glioblastomas, but not in lower grade astrocytomas and secondary glioblastomas |
Human | DKK3 | 27122 | dickkopf WNT signaling pathway inhibitor 3 | RIG expression was either not detected or detected only at low levels in cultured glioma cells and primary glioblastoma specimens compared to normal brain cells. |
Human | CHEK2 | 11200 | checkpoint kinase 2 | a role of CHEK2 in the pathway of alternative TP53 inactivation in primary glioblastoma CHEK2 mutations in primary glioblastomas. |
Human | HRK | 8739 | harakiri, BCL2 interacting protein (contains only BH3 domain) | The region around the HRK transcription start site was methylated in 19% of diffuse astrocytomas, in 22% of anaplastic astrocytomas, in 27% of primary glioblastomas, and in 43% of secondary glioblastomas. |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | RESULTS: Expression analysis indicated that CXCR-4 is overexpressed in 57% of the primary glioblastoma tissues and in 88% of the glioblastoma cell lines analyzed. |
Human | VIM | 7431 | vimentin | Vimentin expression correlates with the cytoplasmic localization of wild-type p53 in human primary glioblastoma |
Human | UNG | 7374 | uracil-DNA glycosylase | Genetic alterations of UNG may play a role in the development of a subset of primary glioblastomas. |
Human | TP53 | 7157 | tumor protein p53 | p53 protein expression in vivo does not correlate with the outcome of patients with primary in primary glioblastoma |
Human | PRKCA | 5578 | protein kinase C, alpha | Human glioblastoma U-87 has many of the distinguishing phenotypic features of primary glioblastoma, including an autocrine form of proliferation, high levels of protein kinase C alpha (PKC alpha), and infiltration via white matter tracts. |
Human | PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | an important role of PIK3CA gene aberrations in the molecular pathogenesis of primary glioblastomas |
Human | OSM | 5008 | oncostatin M | We conclude that OSM inhibits proliferation of human astroglioma cells and primary glioblastoma cells via the gp130/OSMRbeta receptor complex. OSM suppressed the proliferation of primary glioblastoma cells, but not that of normal astrocytes. |
Human | MGMT | 4255 | O-6-methylguanine-DNA methyltransferase | High incidence of MGMT promoter methylation in primary glioblastomas without correlation with TP53 gene mutations is reporterd |
Human | ITGAV | 3685 | integrin, alpha V | significant difference in the expression of the beta(3) integrin subunit between primary glioblastomas compared with low-grade gliomas |
Human | IGF1R | 3480 | insulin-like growth factor 1 receptor | Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling |
Human | GPR26 | 2849 | G protein-coupled receptor 26 | Study has identified GPR26 to be a genetic indicator of primary glioblastoma, suggesting that it could be a suppressor of primary glioblastoma development |
Human | GFAP | 2670 | glial fibrillary acidic protein | GFAP expression correlates with cytoplasmic expression of wild-type p53 in human primary glioblastoma |
Human | EPHA2 | 1969 | EPH receptor A2 | We demonstrate in the current study that the EphA2 protein is restrictedly expressed in primary glioblastoma multiforme and anaplastic astrocytoma tissues in comparison to normal brain tissues. |
Human | CCND3 | 896 | cyclin D3 | Amplification and overexpression of the CCND3 gene was detected in the glioblastoma cell line CCF-STTG1, as well as in one primary glioblastoma and in the sarcomatous component of one gliosarcoma. |
Human | BIRC5 | 332 | baculoviral IAP repeat containing 5 | Expression in primary glioblastomas |