Human | CITED4 | 163732 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | mutational study of CITED4 in 24 glial tumors (22 primary glioblastomas, 1 low-grade astrocytoma & its recurrent secondary glioblastoma) |
Human | THEM4 | 117145 | thioesterase superfamily member 4 | Because loss of CTMP function and/or expression may remove the inhibitory effects on Akt and promote tumorigenesis, we studied 93 primary glioblastomas and nine glioblastoma cell lines for CTMP deletion, mutation, promoter hypermethylation, and mRNA expression. |
Human | AGAP2 | 116986 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | Here, we investigated two further Pi3k/Akt pathway genes, namely PIK3CA (3q26.3) and phosphatidylinositol-3-kinase enhancer (PIKE) (CENTG1, 12q14), for genetic alteration and aberrant expression in a series of 97 primary glioblastomas. an important role of PIKE gene aberrations in the molecular pathogenesis of primary glioblastomas |
Human | MARK4 | 57787 | MAP/microtubule affinity-regulating kinase 4 | Following our previous studies on structural 19q chromosome rearrangements in gliomas, we have undertaken a detailed FISH analysis of the breakpoints and identified a 19q13.2 intrachromosomal amplification of the MAP/microtubule affinity-regulating kinase 4 (MARK4) gene in three primary glioblastoma cell lines. |
Human | NDRG2 | 57447 | NDRG family member 2 | NDRG2 as a candidate tumor suppressor gene that is epigenetically silenced in the majority of primary glioblastomas, but not in lower grade astrocytomas and secondary glioblastomas |
Human | DKK3 | 27122 | dickkopf WNT signaling pathway inhibitor 3 | RIG expression was either not detected or detected only at low levels in cultured glioma cells and primary glioblastoma specimens compared to normal brain cells. |
Human | CHEK2 | 11200 | checkpoint kinase 2 | CHEK2 mutations in primary glioblastomas. a role of CHEK2 in the pathway of alternative TP53 inactivation in primary glioblastoma |
Human | HRK | 8739 | harakiri, BCL2 interacting protein (contains only BH3 domain) | The region around the HRK transcription start site was methylated in 19% of diffuse astrocytomas, in 22% of anaplastic astrocytomas, in 27% of primary glioblastomas, and in 43% of secondary glioblastomas. |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | RESULTS: Expression analysis indicated that CXCR-4 is overexpressed in 57% of the primary glioblastoma tissues and in 88% of the glioblastoma cell lines analyzed. |
Human | VIM | 7431 | vimentin | Vimentin expression correlates with the cytoplasmic localization of wild-type p53 in human primary glioblastoma |
Human | UNG | 7374 | uracil-DNA glycosylase | Genetic alterations of UNG may play a role in the development of a subset of primary glioblastomas. |
Human | TP53 | 7157 | tumor protein p53 | p53 protein expression in vivo does not correlate with the outcome of patients with primary in primary glioblastoma |
Human | PRKCA | 5578 | protein kinase C, alpha | Human glioblastoma U-87 has many of the distinguishing phenotypic features of primary glioblastoma, including an autocrine form of proliferation, high levels of protein kinase C alpha (PKC alpha), and infiltration via white matter tracts. |
Human | PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | an important role of PIK3CA gene aberrations in the molecular pathogenesis of primary glioblastomas |
Human | OSM | 5008 | oncostatin M | OSM suppressed the proliferation of primary glioblastoma cells, but not that of normal astrocytes. We conclude that OSM inhibits proliferation of human astroglioma cells and primary glioblastoma cells via the gp130/OSMRbeta receptor complex. |
Human | MGMT | 4255 | O-6-methylguanine-DNA methyltransferase | High incidence of MGMT promoter methylation in primary glioblastomas without correlation with TP53 gene mutations is reporterd |
Human | ITGAV | 3685 | integrin, alpha V | significant difference in the expression of the beta(3) integrin subunit between primary glioblastomas compared with low-grade gliomas |
Human | IGF1R | 3480 | insulin-like growth factor 1 receptor | Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling |
Human | GPR26 | 2849 | G protein-coupled receptor 26 | Study has identified GPR26 to be a genetic indicator of primary glioblastoma, suggesting that it could be a suppressor of primary glioblastoma development |
Human | GFAP | 2670 | glial fibrillary acidic protein | GFAP expression correlates with cytoplasmic expression of wild-type p53 in human primary glioblastoma |
Human | EPHA2 | 1969 | EPH receptor A2 | We demonstrate in the current study that the EphA2 protein is restrictedly expressed in primary glioblastoma multiforme and anaplastic astrocytoma tissues in comparison to normal brain tissues. |
Human | CCND3 | 896 | cyclin D3 | Amplification and overexpression of the CCND3 gene was detected in the glioblastoma cell line CCF-STTG1, as well as in one primary glioblastoma and in the sarcomatous component of one gliosarcoma. |
Human | BIRC5 | 332 | baculoviral IAP repeat containing 5 | Expression in primary glioblastomas |