Human | ACTR5 | 79913 | ARP5 actin-related protein 5 homolog (yeast) | Arp5 is involved in the process of DNA double strand break repair through the regulation of the chromatin remodelling machinery |
Human | NHEJ1 | 79840 | nonhomologous end-joining factor 1 | Review focuses on the proteins involved in the NHEJ pathway, the major pathway for repair of DNA double-strand breaks, which can become molecular targets in the treatment of cancer |
Human | TDP1 | 55775 | tyrosyl-DNA phosphodiesterase 1 | TDP1 is also required for the repair of single stranded breaks induced by ionizing radiation (IR), though not measurably for IR-induced DNA double-strand breaks The role of TDP1 in 3'-phosphoglycolate processing during in vitro end joining of DNA double-strand breaks a role for hTdp1 in repair of free radical-mediated DNA double strand breaks bearing terminally blocked 3' overhangs |
Human | NLRP2 | 55655 | NLR family, pyrin domain containing 2 | is phosphorylated by ATM, the product of the Nbs1, an ataxia-telangiectasia mutated gene and a member of the phosphatidylinositol 3-kinase-related family of serine-threonine kinasesin response to DNA double-strand breaks |
Human | BBC3 | 27113 | BCL2 binding component 3 | histones and a ubiquitin conjugate protein UBC9, which are involved in DNA double-strand break (DSB) repair were significantly down-regulated in the PUMA-overexpressing apoptotic cells, suggesting the detection of DSB in the apoptotic process |
Human | SETX | 23064 | senataxin | defect in 2O2-induced DNA double-strand breaks repair was corrected by full-length SETX cDNA |
Human | PNKP | 11284 | polynucleotide kinase 3'-phosphatase | polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination |
Human | CHEK2 | 11200 | checkpoint kinase 2 | The response of promyelocytic leukemia nuclear bodies to DNA double-strand breaks is regulated by NBS1, ATM, Chk2, and ATR Mre11 stabilizes Nbs1 and Rad50 and MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks |
Human | RAD50 | 10111 | RAD50 homolog (S. cerevisiae) | activation in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction Data reveal a role for the Rad50 complex in V(D)J recombination, and demonstrate that the protein product of the disease-causing allele responsible for Nijmegen breakage syndrome encodes a protein with residual DNA double-strand break repair activity Mre11 stabilizes Nbs1 and Rad50 and MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks |
Human | MDC1 | 9656 | mediator of DNA-damage checkpoint 1 | MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks |
Human | RECQL4 | 9401 | RecQ protein-like 4 | Findings suggest a role for RECQL4 in the repair of DNA double-strand breaks by homologous recombination and shed new light onto RECQL4's function in human cells |
Human | RNF8 | 9025 | ring finger protein 8, E3 ubiquitin protein ligase | RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins |
Human | CCNA1 | 8900 | cyclin A1 | These findings establish a novel function for cyclin A1 and CDK2 in DNA double strand break repair following radiation damage |
Human | RAD54L | 8438 | RAD54-like (S. cerevisiae) | Rad54 protein causes dissociation of joint molecules by ATP-dependent branch-migration and therefore plays an important role in double strand DNA break repair |
Human | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Results describe the response of BRCA1 at DNA double-strand breaks produced by laser microirradiation, and show that accumulation of the BRCA1 N terminus, but not the C terminus, at DSBs depended on Ku80 |
Human | XRCC4 | 7518 | X-ray repair complementing defective repair in Chinese hamster cells 4 | DNA Ligase IV/XRCC4 recruitment by DNA-PK to DNA double-strand breaks prevents the formation of long ssDNA ends at double-strand breaks during the S phase |
Human | XRCC3 | 7517 | X-ray repair complementing defective repair in Chinese hamster cells 3 | XRCC3 promotes homology-directed repair of DNA double-strand breaks in mammalian cells |
Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III utilize an alternative route for DNA double-strand breaks rejoining |
Human | XPC | 7508 | xeroderma pigmentosum, complementation group C | p53 determines the switch by regulating xpc and DNA double-strand breaks in antineoplastic agent treatment of glioblastoma multiforme |
Human | WRN | 7486 | Werner syndrome, RecQ helicase-like | altered DNA double-strand break repair in CML cells is caused by the increased activity of an alternative nonhomologous end-joining repair pathway, involving DNA ligase IIIalpha and WRN a novel pathway in which Nbs1 may recruit WRN to the site of DNA double strand breaks in an ATM-dependent manner Results show that WRN plays an important role in the protection of HeLa cells against the toxicity of the benzene metabolite hydroquinone, specifically in mounting a normal DNA damage response following the induction of DNA double-strand breaks |
Human | TP53BP1 | 7158 | tumor protein p53 binding protein 1 | 53BP1 only has limited checkpoint functions but rather acts as an adaptor in the repair of DNA double strand breaks These data indicate the existence of a DNA double-strand break-repair protein that functions upstream of 53BP1 and contributes to the normal development of the human immune system Additional elements in 53BP1 that facilitate recognition of DNA double-strand breaks, were identified 53BP1 has the potential to participate directly in the repair of DNA double-strand breaks 53BP1 senses DNA double-stranded breaks indirectly through changes in higher-order chromatin structure that expose the 53BP1 binding site |
Human | TP53 | 7157 | tumor protein p53 | Tumour protein p53 plays a role in facilitating histone H2AX phosphorylation, an important step in the mobilization of the DNA repair machinery at the site of DNA double-strand breaks |
Human | TERT | 7015 | telomerase reverse transcriptase | suppression of the telomerase catalytic subunit hTERT expression abrogates the cellular response to DNA double strand breaks |
Human | TERF2 | 7014 | telomeric repeat binding factor 2 | TRF2 is critical for the protection of A549 cells from both telomere erosion and DNA double-strand breaks driven by salvicine |
Human | SRSF1 | 6426 | serine/arginine-rich splicing factor 1 | The vivo depletion of ASF/SF2 results in a hypermutation phenotype likely due to DNA rearrangements, reflected in the rapid appearance of DNA double-strand breaks and high-molecular-weight DNA fragments |