Human | ACTR5 | 79913 | ARP5 actin-related protein 5 homolog (yeast) | Arp5 is involved in the process of DNA double strand break repair through the regulation of the chromatin remodelling machinery |
Human | NHEJ1 | 79840 | nonhomologous end-joining factor 1 | Review focuses on the proteins involved in the NHEJ pathway, the major pathway for repair of DNA double-strand breaks, which can become molecular targets in the treatment of cancer |
Human | TDP1 | 55775 | tyrosyl-DNA phosphodiesterase 1 | a role for hTdp1 in repair of free radical-mediated DNA double strand breaks bearing terminally blocked 3' overhangs The role of TDP1 in 3'-phosphoglycolate processing during in vitro end joining of DNA double-strand breaks TDP1 is also required for the repair of single stranded breaks induced by ionizing radiation (IR), though not measurably for IR-induced DNA double-strand breaks |
Human | NLRP2 | 55655 | NLR family, pyrin domain containing 2 | is phosphorylated by ATM, the product of the Nbs1, an ataxia-telangiectasia mutated gene and a member of the phosphatidylinositol 3-kinase-related family of serine-threonine kinasesin response to DNA double-strand breaks |
Human | BBC3 | 27113 | BCL2 binding component 3 | histones and a ubiquitin conjugate protein UBC9, which are involved in DNA double-strand break (DSB) repair were significantly down-regulated in the PUMA-overexpressing apoptotic cells, suggesting the detection of DSB in the apoptotic process |
Human | SETX | 23064 | senataxin | defect in 2O2-induced DNA double-strand breaks repair was corrected by full-length SETX cDNA |
Human | PNKP | 11284 | polynucleotide kinase 3'-phosphatase | polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination |
Human | CHEK2 | 11200 | checkpoint kinase 2 | Mre11 stabilizes Nbs1 and Rad50 and MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks The response of promyelocytic leukemia nuclear bodies to DNA double-strand breaks is regulated by NBS1, ATM, Chk2, and ATR |
Human | RAD50 | 10111 | RAD50 homolog (S. cerevisiae) | activation in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes Data reveal a role for the Rad50 complex in V(D)J recombination, and demonstrate that the protein product of the disease-causing allele responsible for Nijmegen breakage syndrome encodes a protein with residual DNA double-strand break repair activity reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction Mre11 stabilizes Nbs1 and Rad50 and MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks |
Human | MDC1 | 9656 | mediator of DNA-damage checkpoint 1 | MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks |
Human | RECQL4 | 9401 | RecQ protein-like 4 | Findings suggest a role for RECQL4 in the repair of DNA double-strand breaks by homologous recombination and shed new light onto RECQL4's function in human cells |
Human | RNF8 | 9025 | ring finger protein 8, E3 ubiquitin protein ligase | RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins |
Human | CCNA1 | 8900 | cyclin A1 | These findings establish a novel function for cyclin A1 and CDK2 in DNA double strand break repair following radiation damage |
Human | RAD54L | 8438 | RAD54-like (S. cerevisiae) | Rad54 protein causes dissociation of joint molecules by ATP-dependent branch-migration and therefore plays an important role in double strand DNA break repair |
Human | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Results describe the response of BRCA1 at DNA double-strand breaks produced by laser microirradiation, and show that accumulation of the BRCA1 N terminus, but not the C terminus, at DSBs depended on Ku80 |
Human | XRCC4 | 7518 | X-ray repair complementing defective repair in Chinese hamster cells 4 | DNA Ligase IV/XRCC4 recruitment by DNA-PK to DNA double-strand breaks prevents the formation of long ssDNA ends at double-strand breaks during the S phase |
Human | XRCC3 | 7517 | X-ray repair complementing defective repair in Chinese hamster cells 3 | XRCC3 promotes homology-directed repair of DNA double-strand breaks in mammalian cells |
Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III utilize an alternative route for DNA double-strand breaks rejoining |
Human | XPC | 7508 | xeroderma pigmentosum, complementation group C | p53 determines the switch by regulating xpc and DNA double-strand breaks in antineoplastic agent treatment of glioblastoma multiforme |
Human | WRN | 7486 | Werner syndrome, RecQ helicase-like | a novel pathway in which Nbs1 may recruit WRN to the site of DNA double strand breaks in an ATM-dependent manner Results show that WRN plays an important role in the protection of HeLa cells against the toxicity of the benzene metabolite hydroquinone, specifically in mounting a normal DNA damage response following the induction of DNA double-strand breaks altered DNA double-strand break repair in CML cells is caused by the increased activity of an alternative nonhomologous end-joining repair pathway, involving DNA ligase IIIalpha and WRN |
Human | TP53BP1 | 7158 | tumor protein p53 binding protein 1 | These data indicate the existence of a DNA double-strand break-repair protein that functions upstream of 53BP1 and contributes to the normal development of the human immune system 53BP1 only has limited checkpoint functions but rather acts as an adaptor in the repair of DNA double strand breaks 53BP1 has the potential to participate directly in the repair of DNA double-strand breaks 53BP1 senses DNA double-stranded breaks indirectly through changes in higher-order chromatin structure that expose the 53BP1 binding site Additional elements in 53BP1 that facilitate recognition of DNA double-strand breaks, were identified |
Human | TP53 | 7157 | tumor protein p53 | Tumour protein p53 plays a role in facilitating histone H2AX phosphorylation, an important step in the mobilization of the DNA repair machinery at the site of DNA double-strand breaks |
Human | TERT | 7015 | telomerase reverse transcriptase | suppression of the telomerase catalytic subunit hTERT expression abrogates the cellular response to DNA double strand breaks |
Human | TERF2 | 7014 | telomeric repeat binding factor 2 | TRF2 is critical for the protection of A549 cells from both telomere erosion and DNA double-strand breaks driven by salvicine |
Human | SRSF1 | 6426 | serine/arginine-rich splicing factor 1 | The vivo depletion of ASF/SF2 results in a hypermutation phenotype likely due to DNA rearrangements, reflected in the rapid appearance of DNA double-strand breaks and high-molecular-weight DNA fragments |