Human | L2HGDH | 79944 | L-2-hydroxyglutarate dehydrogenase | MRI shows subcortical leukoencephalopathy with cavitation Cystic cavitation of the white matter |
Human | GGCT | 79017 | gamma-glutamylcyclotransferase | presence of extra electron density/ligands and conservation at the sequence and structure levels, it is likely that the cavity has a crucial role in the function of LOC79017 and its structural neighbors possibly as an active site or ligand-binding site |
Human | TMPRSS11E | 28983 | transmembrane protease, serine 11E | The domain of DESC1 exhibits a trypsin-like serine proteinase fold with a thrombin-like S1 pocket, a urokinase-type plasminogen activator-type S2 pocket, to accept small residues, and an open hydrophobic S3/S4 cavity to accept large hydrophobic residues |
Human | SEC14L2 | 23541 | SEC14-like 2 (S. cerevisiae) | SPF has two domain topology, and the ligand binding cavity has a peculiar horseshoe-like shape |
Human | GLMN | 11146 | glomulin, FKBP associated protein | Multiple layers of glomus cells lining blood-filled cavities |
Human | VTN | 7448 | vitronectin | reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor |
Human | VEGFA | 7422 | vascular endothelial growth factor A | High production of VEGF and low production of IL-18 by polymorphonuclear leukocytes of cancer patients may promote neoangiogenesis and may be important for benign tumour cells to acquire metastatic phenotype in the early stage of oral cavity cancer |
Human | TP53 | 7157 | tumor protein p53 | p53 mutations are common among oral cavity cancers in the Brazilian population Human papillomavirus infection and/or changes in p53 protein coexist in oral cavity papillomas |
Human | SLC19A1 | 6573 | solute carrier family 19 (folate transporter), member 1 | implicate amino acids in transmembrane domains (TMDs) 4, 5, 7, 8, 10, and 11, but not in TMDs 1, 2, 3, 6, 9, or 12, as important structural or functional components of the putative hydrophilic cavity for binding of anionic folate substrates |
Human | SCN5A | 6331 | sodium channel, voltage-gated, type V, alpha subunit | Residue hNav1.5-S401 at D1S6 is facing the inner cavity and is in close proximity to the receptor sites for batrachotoxin and for local anesthetics |
Human | RLBP1 | 6017 | retinaldehyde binding protein 1 | Trp-165, Met-208, Met-222, Met-225, and Trp-244 are components of the CRALBP ligand binding cavity |
Human | PLAUR | 5329 | plasminogen activator, urokinase receptor | reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor |
Human | PLAU | 5328 | plasminogen activator, urokinase | reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor |
Human | NTF3 | 4908 | neurotrophin 3 | Fibroblasts genetically modified to express human neurotrophin-3 (NT-3) were placed in, and distal to, the lesion cavity in chronic spinal cord injured rats; grafted animals exhibited significant growth of corticospinal axons |
Human | NOTCH3 | 4854 | notch 3 | Jagged-1 is the primary Notch3 ligand in ovarian carcinoma and Jagged-1/Notch3 interaction constitutes a juxtacrine loop promoting proliferation and dissemination of ovarian cancer cells within the intraperitoneal cavity |
Human | MAOB | 4129 | monoamine oxidase B | These data suggest that the structural properties of the active site cavities in rat MAOs are significantly different from the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs |
Human | LMNB1 | 4001 | lamin B1 | Cavitating white matter degeneration |
Human | KCNJ13 | 3769 | potassium inwardly-rectifying channel, subfamily J, member 13 | Occasional optically empty vitreous cavity |
Human | KCNH2 | 3757 | potassium voltage-gated channel, subfamily H (eag-related), member 2 | positioning of S6 aromatic residues relative to the central cavity of the channel, not inactivation per se determines drug block of HERG or eag channels |
Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | High production of VEGF and low production of IL-18 by polymorphonuclear leukocytes of cancer patients may promote neoangiogenesis and may be important for benign tumour cells to acquire metastatic phenotype in the early stage of oral cavity cancer |
Human | GLRA1 | 2741 | glycine receptor, alpha 1 | Molecular modeling was used to thread the glycine receptor sequence onto a nicotinic acetylcholine receptor template; I229 and A288 are near-neighbors that can cross-link and providing evidence that these residues contribute to a single binding cavity |
Human | FTL | 2512 | ferritin, light polypeptide | MRI imaging shows cavitation of the basal ganglia Brain tissue shows cavitation of the basal ganglia |
Human | FKBP1A | 2280 | FK506 binding protein 1A, 12kDa | fndings suggest that the peptidyl-prolyl isomerase activity requires only the hydrophobic cavity that captures the Pro-containing peptide |
Human | FGF2 | 2247 | fibroblast growth factor 2 (basic) | bFGF-eluting stents are effective for accelerating organization of the thoracic aneurysm cavity and developing neointima |
Human | DHFR | 1719 | dihydrofolate reductase | analysis of human dihydrofolate reductase folding trajectories inside the GroEL GroES chaperonin cavity and free in solution |