Human | TUBB2B | 347733 | tubulin, beta 2B class IIb | The data suggest that the ratio of beta-tubulin classes II and V mRNA could be useful as a biomarker for NSCLC tumor differentiation and/or NSCLC aggressiveness |
Human | TMPRSS6 | 164656 | transmembrane protease, serine 6 | Data show that genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation |
Human | PRUNE2 | 158471 | prune homolog 2 (Drosophila) | BMCC1 is a new member of prognostic factors for NBL and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells |
Human | EGLN3 | 112399 | egl-9 family hypoxia-inducible factor 3 | Overexpression of the oxygen sensor PHD-3 is associated with tumor aggressiveness in pancreatic endocrine tumors |
Human | EGLN2 | 112398 | egl-9 family hypoxia-inducible factor 2 | Overexpression of the oxygen sensor PHD-1 is associated with tumor aggressiveness in pancreatic endocrine tumors |
Human | SPINK7 | 84651 | serine peptidase inhibitor, Kazal type 7 (putative) | results suggest that ECRG2 inhibits aggressiveness of cancer cell, possibly through the down-regulation of uPA/plasmin activity |
Human | HPSE2 | 60495 | heparanase 2 | Heparanase expression seems to be involved in the invasiveness and aggressiveness of head and neck squamous cell carcinomas |
Human | PRUNE | 58497 | prune exopolyphosphatase | GSK-3 and h-prune cooperatively regulate the disassembly of focal adhesions to promote cell migration and that h-prune is useful as a marker for tumor aggressiveness prune has a role in breast neoplasm aggressiveness |
Human | RAB25 | 57111 | RAB25, member RAS oncogene family | Rab25 signalling pathway plays a role in the regulation of cell proliferation and apoptosis in ovarian cancer cells, which indicates that the Rab25 gene plays a definite role in the development and aggressiveness of human ovarian cancer |
Human | HIF1AN | 55662 | hypoxia inducible factor 1, alpha subunit inhibitor | Overexpression of the oxygen sensor FIH1 is associated with tumor aggressiveness in pancreatic endocrine tumors |
Human | WWOX | 51741 | WW domain containing oxidoreductase | loss of WWOX expression plays different roles in tumorigenesis of distinct histotypes and subtypes of NSCLC and is related to high aggressiveness (G3; high proliferating activity) of tumors |
Human | KLK14 | 43847 | kallikrein-related peptidase 14 | KLK14 is clearly overexpressed in breast cancer in comparison to normal breast tissues and is positively associated with conventional parameters of tumour aggressiveness |
Human | CHMP2B | 25978 | charged multivesicular body protein 2B | |
Human | KLK5 | 25818 | kallikrein-related peptidase 5 | expression in prostate cancer negatively correlated with cancer aggressiveness |
Human | FSCN2 | 25794 | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) | In ovarian tumors fascin is associated with certain features of increased tumor aggressiveness |
Human | CADM1 | 23705 | cell adhesion molecule 1 | TSLC1 represents central effector gene for controlling biological aggressiveness of pulmonary adenocarcinoma and is essential biomarker for predicting prognosis |
Human | LPAR3 | 23566 | lysophosphatidic acid receptor 3 | Expression of LPA3 during ovarian carcinogenesis contributes to ovarian cancer aggressiveness, suggesting that the targeting of LPA production and action may have potential for the treatment of ovarian cancer |
Human | VPS13A | 23230 | vacuolar protein sorting 13 homolog A (S. cerevisiae) | |
Human | NES | 10763 | nestin | nestin may be one mediator of N-myc-associated tumor aggressiveness of human neuroblastoma |
Human | ZEB2 | 9839 | zinc finger E-box binding homeobox 2 | Over expression of snail is associated with breast carcinoma aggressiveness |
Human | LPAR2 | 9170 | lysophosphatidic acid receptor 2 | Expression of LPA2 during ovarian carcinogenesis contributes to ovarian cancer aggressiveness, suggesting that the targeting of LPA production and action may have potential for the treatment of ovarian cancer |
Human | CFLAR | 8837 | CASP8 and FADD-like apoptosis regulator | c-FLIP might contribute to the carcinogenesis and aggressiveness of endometrial carcinoma and might be a useful prognostic factor in the tumor |
Human | HMGA2 | 8091 | high mobility group AT-hook 2 | HMGA2 overexpression is associated with aggressiveness of oral carcinoma |
Human | ADAM12 | 8038 | ADAM metallopeptidase domain 12 | in liver cancers ADAM12 expression is associated with tumor aggressiveness and progression |
Human | ALDH5A1 | 7915 | aldehyde dehydrogenase 5 family, member A1 | |