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Genes (15)
Species: human : 15 | |
Human | UTS2D | 257313 | | vascular remodelling processes in conjunction with enhanced vasoconstriction are involved in the pathogenesis of pulmonary hypertension; UII may play a novel role in the pathogenesis of this disorder | Human | TRPV1 | 7442 | transient receptor potential cation channel, subfamily V, member 1 | Tonic activation of TRPV1 channels in the abdominal viscera by yet unidentified nonthermal factors inhibits skin vasoconstriction and thermogenesis, thus having a suppressive effect on body temperature | Human | TRPC1 | 7220 | transient receptor potential cation channel, subfamily C, member 1 | hTRPC1 is an important Ca(2+)-permeable channel that mediates pulmonary vasoconstriction when pulmonary artery smooth muscle cell intracellular Ca2+ stores are depleted | Human | ROCK1 | 6093 | Rho-associated, coiled-coil containing protein kinase 1 | Rho kinase mediates both early- and late-phase cold-induced vasoconstriction (VC) providing a putative mechanism through which both adrenergic and nonadrenergic cold-induced VC occurs in an in vivo human thermoregulatory model | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | dexamethasone reduces vasoconstriction to electrical field stimulation in rat mesenteric arteries from spontaneously hypertensive rats by decreasing COX-2 expression, decreasing the smooth muscle TXA(2) release induced by alpha-adrenoceptor activation | Human | PRKCQ | 5588 | protein kinase C, theta | PKC theta activation induces insulin-mediated vasoconstriction by inhibition of Akt and stimulation of ERK1/2 in muscle resistance arteries | Human | PRKCE | 5581 | protein kinase C, epsilon | absence of protein kinase C-epsilon allows increased expression of potassium(V) channels (like Kv3.1b) to occur in pulmonary artery smooth muscle cells, which likely contributes to decreased hypoxic pulmonary vasoconstriction | Human | NPY | 4852 | neuropeptide Y | NPY participates in sympathetically mediated cutaneous vasoconstriction in humans during whole body cooling | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Glu298Asp variant of the eNOS gene provides no additional information on the genetic basis of alpha(2)-adrenoceptor-induced coronary vasoconstriction, which appears exclusively associated to the 825T allele at GNB3 | Human | KCNMA1 | 3778 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | propose that MaxiK channels via direct c-Src-dependent phosphorylation play a significant role supporting vasoconstriction after activation of G protein-coupled receptors by vasoactive substances and neurotransmitters | Human | HTR2A | 3356 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | In the human internal thoracic artery, 5-hydroxytryptamine (5-HT)-induced vasoconstriction is mediated by activation of both 5-HT2A and 5-HT1B receptors | Human | GNB3 | 2784 | guanine nucleotide binding protein (G protein), beta polypeptide 3 | Title:Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction.|Association:Y|Conclusion:Contrary to the initial analysis, the Glu298Asp variant of the eNOS gene provides no additional information on the genetic basis of alpha(2)-adrenoceptor-induced coronary vasoconstriction, which appears exclusively associated to the 825T allele at GNB3. Analysis of modifying genes appears crucial for the understanding of genetic associations. GNB3 825T is likely gene for which natural selection of an allele favoring conservation and vasoconstriction promotes hypertension susceptibility | Human | EDN1 | 1906 | endothelin 1 | Suggest ET-1 and alpha-adrenergic receptors regulate leg skeletal muscle blood flow at rest and suggest a similar, intensity-dependent "lysis" of peripheral ET and alpha-adrenergic vasoconstriction during dynamic exercise In patients with acute lung injury/ARDS, ET-1 is produced mainly in the lung and is associated not only with pulmonary vasoconstriction but also the development of permeability oedema, leading to the impairment of oxygenation ET-1 could be implicated in the pathogenesis of appendicitis by inducing appendiceal ischemia through vasoconstriction Title:Interactive effects of anger expression and ET-1 Lys198Asn polymorphism on vasoconstriction reactivity to behavioral stress|Association:Not Found|Conclusion:Individuals with a genetic predisposition for exaggerated vasoconstriction who also display low AM skills may be at particular risk for development of stress-induced EH. Such individuals may particularly benefit from anger management training. 21 amino acid peptide exerts a wide range of biological activities including vasoconstriction, mitogenesis and inotropic effects on the heart Elevated levels of ET-1 in hypertensive patients on hemodialysis contribute to systemic vasoconstriction and may be a marker for vascular dysfunction in this patient population Elevated plasma ET-1 levels following acute myocardial infarction and recanalization in humans probably contributes to the coronary vasoconstriction that underlies the myocardial ischaemia and ventricular dysfunction, as related in this review | Human | ADRA2C | 152 | adrenoceptor alpha 2C | Increased expression of alpha(2C)-adrenoceptors may contribute to enhanced cold-induced vasoconstriction and Raynaud's phenomenon An estrogen-dependent increase in expression of cold-sensitive alpha(2C)-ARs may contribute to the increased activity of cold-induced vasoconstriction under estrogen-replete conditions | Human | ADRA2B | 151 | adrenoceptor alpha 2B | Title:Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response.|Association:Not Found|Conclusion:These findings suggest that the del301-303 polymorphism does not contribute significantly to interindividual in vivo variability in response to alpha2-AR activation in the hand vein. These data indicate that alpha-2 adrenergic receptors contribute significantly to CBR-induced vasoconstriction in the human leg under resting conditions |
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