Genes (192)
Species: human : 188 mouse : 4 | |
Mouse | PHF17 | 79960 | PHD finger protein 17 | Jade-1 inhibited renal cancer cell growth, colony formation, and tumor formation in nude mice. | Mouse | MET | 4233 | met proto-oncogene | We examined the role of increased expression of HGFR kinase in in vivo growth of renal carcinoma. These results indicate for the first time that overexpression of HGFR tyrosine kinase in renal carcinoma cells participates in rapid tumor growth in vivo. Overexpression of hepatocyte growth factor receptor in renal carcinoma cells indirectly stimulates tumor growth in vivo. | Mouse | HIF1A | 3091 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | CONCLUSIONS: These results suggest that HIF-1alpha may have important roles in bladder and renal cancer angiogenesis and proliferation. | Mouse | FES | 2242 | feline sarcoma oncogene | Oncogenes src, fps, and mos were not expressed in any of the tumors tested but oncogene myc was transcribed in most of the tumors and myc was over-expressed in 3 tumors passaged in nude mice (Ewing sarcoma, large intestine carcinoma and kidney carcinoma) and in primary fibrous histiocytoma. | Human | FLCN | 201163 | folliculin | BHD is involved in the entire spectrum of histological types of renal tumors, suggesting its major role in kidney cancer tumorigenesis | Human | FAM129A | 116496 | family with sequence similarity 129, member A | Importantly, ;Niban; is well expressed even in small primary rat Eker renal tumors, more than in progressed cell lines, and is also expressed in human renal carcinoma cells, but not in normal human or rat kidneys. In addition, Niban was also expressed in other renal carcinoma models, including Tsc1 and Tsc2 knockout mice, and various types of human renal cell carcinomas. | Human | MAL2 | 114569 | mal, T-cell differentiation protein 2 (gene/pseudogene) | For comparison with normal epithelial tissue, different types of renal carcinoma were also analyzed, revealing alterations in MAL2 expression/distribution dependent on the particular histological type of the tumor. | Human | DIRC2 | 84925 | disrupted in renal carcinoma 2 | Subsequent positional cloning of the 3q21 chromosomal breakpoint revealed that this breakpoint disrupts a novel gene, DIRC2 (disrupted in renal cancer 2). Through a subsequent positional cloning effort we found that this breakpoint targets a hitherto unidentified gene, designated DIRC2 (disrupted in renal cancer 2). | Human | TUBA1C | 84790 | tubulin, alpha 1c | A novel series of 6,7,2,3,4-substituted-1,2,3,4-tetrahydro-2-phenyl- 4-quinolones were synthesized and evaluated for interactions with tubulin and for cytotoxic activity against a panel of human tumor cell lines, including ileocecal carcinoma (HCT-8), breast cancer (MCF-7), lung carcinoma (A-549), epidermoid carcinoma of the nasopharynx (KB), renal cancer (CAKI-1), and melanoma cancer (SKMEL-2). | Human | PHF17 | 79960 | PHD finger protein 17 | Click here to display 16 evidence detail records. | Human | CDC73 | 79577 | cell division cycle 73 | renal cancer-associated mutations in parafibromin occur in the absence of von Hippel-Lindau mutation | Human | RHOU | 58480 | ras homolog family member U | On the other hand, WRCH1 mRNA was significantly down-regulated in 6 cases of colon tumors, 2 cases of primary kidney cancer and breast cancer. | Human | MUC3B | 57876 | mucin 3B, cell surface associated | MUC1, MUC3 and MUC6 were expressed both in normal kidney and in renal carcinomas. In renal carcinoma, we showed a heterogeneous expression of MUC1 and MUC3 with an over-expression of MUC3 in renal clear cell carcinoma. | Human | AHRR | 57491 | aryl-hydrocarbon receptor repressor | AhRR mRNA was also detected in various human tissue-derived cell lines, HepG2 (hepatocellular carcinoma), MCF-7 (breast carcinoma), LS-180 (colon carcinoma), ACHN (renal carcinoma), A549 (lung carcinoma), HT-1197 (bladder carcinoma), HeLa (cervix of uterus adenocarcinoma), NEC14 (testis embryonal carcinoma), and OMC-3 (ovarian carcinoma). | Human | DLL4 | 54567 | delta-like 4 (Drosophila) | In this study, we assessed the expression of DLL4 in primary renal cancer and investigated the biological function of DLL4 in primary endothelial cells. | Human | ANGPT4 | 51378 | angiopoietin 4 | the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma | Human | OSGIN1 | 29948 | oxidative stress induced growth inhibitor 1 | Our data suggest the potential use of OKL38 in diagnosis, prognosis, and/or treatment of kidney cancer. Our data suggest the potential use of OKL38 in diagnosis, prognosis, and/or treatment of kidney cancer. | Human | DNAJC15 | 29103 | DnaJ (Hsp40) homolog, subfamily C, member 15 | Compared with various normal postnatal tissues, approximately 40-90% of these pediatric kidney cancers were hypermethylated in four of the genes, MCJ, RASSF1A, TNFRSF12 and CALCA as determined by a quantitative bisulfite-based assay (MethyLight). | Human | PPP2R3B | 28227 | protein phosphatase 2, regulatory subunit B'', beta | The ability of these analogues to inhibit PP1 and PP2A correlates well with their observed anti-cancer activity against a panel of five cancer cell lines: A2780 (human ovarian carcinoma), G401 (human kidney carcinoma), HT29 (human colorectal carcinoma), H460 (human lung carcinoma) and L1210 (murine leukemia). | Human | PDCD4 | 27250 | programmed cell death 4 (neoplastic transformation inhibitor) | Sensitivity to geldanamycin significantly increased in UO-31 renal cancer cells expressing sense PDCD4 cDNA. | Human | CACYBP | 27101 | calcyclin binding protein | Taken together, our work showed that CacyBP/SIP, as a novel down-regulated gene in renal cell carcinoma, suppressed proliferation and tumorigenesis of renal cancer cells | Human | TNFAIP8 | 25816 | tumor necrosis factor, alpha-induced protein 8 | Western blotting using an antipeptide antibody revealed endogenous SCC-S2 as a approximately 21 kDa cytosolic protein in human breast cancer cells (MDA-MB 231) and renal carcinoma cells (RCC-RS). | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | High expression of AMACR mRNA was found in prostate, liver, and kidney cancers but rarely in stomach and bladder cancers. | Human | PDS5A | 23244 | PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) | SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas. | Human | RNF139 | 11236 | ring finger protein 139 | Ptc protein presents a sterol sensing domain which has been identified in several proteins, including TRC8, recently implicated in hereditary renal carcinoma and which is also expressed as a 2.5-kb transcript in several rat brain areas. Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer. In a series of sporadic renal carcinomas, an acquired TRC8 mutation was identified. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. |
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