| Debug Stats | ### Total Build Time: 26 ms 34.997 KB CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 334 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 210 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytesCONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytesCONCEPT_GENES gt=23 ms Completed: 23 ms rowSize= 33.140 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.152 KBCONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes- Reload Stats
|
Genes (33)
Species:
human : 32 mouse : 1 | |
| Mouse | MDK | 4192 | midkine (neurite growth-promoting factor 2) | Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor. | | Human | PRKCDBP | 112464 | protein kinase C, delta binding protein | The human SRBC gene (hSRBC) was mapped to chromosome region 11p15.5-p15.4, close to marker D11S1323, at which frequent loss of heterozygosity (LOH) has been observed in sporadic breast, lung, ovarian, and other types of adult cancers as well as childhood tumors. | | Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | Oncogene, 2002; 21(27): 4345-49 16.Harada K, Toyooka S, Shivapurkar N et al: Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines.: Cancer Res, 2002; 62(20): 5897-901 17.Rathi A, Virmani AK, Harada K et al: Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms.: Clin Cancer Res, 2003; 9(10 Pt 1): 3674-78 18.Shigematsu H, Suzuki M, Takahashi T et al: Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies.: Int J Cancer, 2005; 113(4): 600-4 19.Gallie BL: Predictive gene testing for retinoblastoma comes of age. | | Human | CHD5 | 26038 | chromodomain helicase DNA binding protein 5 | CHD5 maps within a small region of deletion on 1p36.3 in human neuroblastomas, a common pediatric tumor. | | Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | epigenetic inactivation of RASSF1A may have a role in childhood neoplasm initiation Aberrant promoter methylation of RASSF1A may contribute to the pathogenesis of many different forms of pediatric tumors | | Human | NES | 10763 | nestin | Both the properties of the ST15A cell line and the expression of nestin in medulloblastoma support a neuroectodermal stem cell origin for this childhood tumor. | | Human | HAND2 | 9464 | heart and neural crest derivatives expressed 2 | dHAND also appears to be a reliable and potentially useful clinical diagnostic marker for neuroblastoma, because expression was not dependent on tumor or differentiation stages and other pediatric tumors were dHAND-negative. | | Human | TNFRSF10D | 8793 | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | Lack of expression of DcR1 and DcR2 was widespread (13 of the 15 cell lines and 10 of 15, respectively), both in the adult tumor cell lines and in the pediatric tumor lines. | | Human | AXIN1 | 8312 | axin 1 | a tumor-associated mutation of the Axin gene is generally a rare event in pediatric neoplasms | | Human | VPREB1 | 7441 | pre-B lymphocyte 1 | Furthermore, other pediatric tumors that must be included in a differential diagnosis of precursor B-cell lymphoblastic lymphoma, including precursor T-cell lymphoblastic lymphoma, extramedullary myeloid tumors, and Ewing sarcoma, were also negative for both CD179a and CD179b. | | Human | SMARCB1 | 6598 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | The INI1 promoter is not hypermethylated in pediatric rhabdoid tumors | | Human | PLAG1 | 5324 | pleiomorphic adenoma gene 1 | Lipoblastomas are pediatric neoplasms that are characterized by rearrangements of PLAG1, located in 8q11-12 whereas hibernomas, that resemble brown fat, are associated with 11q13 rearrangements together with often complex chromosomal alterations. | | Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | Significance of P-glycoprotein expression in childhood malignant tumors: correlation between the level of P-glycoprotein expression and tumor histology, clinical outcome, use of therapy, relapse rate and metastatic disease was determined | | Human | NTRK3 | 4916 | neurotrophic tyrosine kinase, receptor, type 3 | Alternatively, STAT 5a expression may be related to the t(12;15)(p13;q25) chromosomal translocation, associated with certain pediatric tumors and recently demonstrated in many secretory carcinomas of the breast, which results in the expression of a tyrosine kinase through ETV6 and NTRK3 fusion. | | Human | NPM1 | 4869 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | The specific translocation was found exclusively in six childhood tumours previously diagnosed as malignant histiocytosis (MH), whereas all adult lymphomas (three ALCL without characteristics of MH, three secondary ALCL following HD) and two paediatric cases of secondary ALCL following HD did not show NPM/ALK gene fusion products. | | Human | NOV | 4856 | nephroblastoma overexpressed | reduced expression of NOV in childhood adrenocortical tumors may play an important role in the process of childhood childhood adrenocortical tumors tumorigenesis | | Human | MYCN | 4613 | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | MycN and DNA methylation are responsible for CRABP-II expression in pediatric tumors and demethylation of CRABP-II may be an early event in tumor development | | Human | MDM2 | 4193 | MDM2 oncogene, E3 ubiquitin protein ligase | Novel splice variants identified in pediatric rhabdomyosarcoma tumors and cell lines | | Human | MCF2 | 4168 | MCF.2 cell line derived transforming sequence | dbl oncogene expression in childhood tumors and tumor cell lines. We conclude that the wide expression of the dbl oncogene in these childhood tumors reduces its value as a molecular marker for their differential diagnosis; on the other hand, the dbl oncogene does not appear to be an essential molecular factor in the process of neuroectodermal differentiation of small round cell tumors of childhood. We have investigated the expression of the dbl proto-oncogene in childhood tumors of known or suspected neuroectodermal origin. | | Human | IGLL1 | 3543 | immunoglobulin lambda-like polypeptide 1 | Furthermore, other pediatric tumors that must be included in a differential diagnosis of precursor B-cell lymphoblastic lymphoma, including precursor T-cell lymphoblastic lymphoma, extramedullary myeloid tumors, and Ewing sarcoma, were also negative for both CD179a and CD179b. | | Human | IGF2 | 3481 | insulin-like growth factor 2 (somatomedin A) | we found 12 childhood hematoblasoma tumours (22%) with LOH in IGDF2, 9 (17%) with loss of imprinting (LOI) and 33 (61%) with retention of imprinting (ROI) | | Human | IGF1R | 3480 | insulin-like growth factor 1 receptor | Immunoblotting demonstrated depletion of the Hsp90 client proteins AKT and the type 1 insulin-like growth factor receptor (IGF1R) in a panel of pediatric tumor cell lines after exposure to GA. | | Human | HIC1 | 3090 | hypermethylated in cancer 1 | aberrant methylation of HIC1 may play a role in the pathogenesis of specific pediatric tumors | | Human | FOXO1 | 2308 | forkhead box O1 | The FKHR gene was first identified from its disruption by the t(2;13) chromosomal translocation seen in the pediatric tumor alveolar rhabdomyosarcoma. | | Human | DAPK1 | 1612 | death-associated protein kinase 1 | Therefore, we examined the methylation status of nine genes (p16(INK4A), MGMT, GSTP1, RASSF1A, APC, DAPK, RARbeta, CDH1 and CDH13) in 175 primary pediatric tumors and 23 tumor cell lines using methylation-specific PCR. |
|
