Genes (35)
Species: human : 35 | |
Human | PTTG1 | 9232 | pituitary tumor-transforming 1 | We conclude that PTTG and FGF-2 expression are potential prognostic markers (and perhaps therapeutic targets) for differentiated thyroid cancer. pituitary tumor transforming gene and fibroblast growth factor-2 expression are potential prognostic markers (and perhaps therapeutic targets) for differentiated thyroid cancer We assessed the expression of PTTG and FGF-2 and its receptor FGF-R-1 in 27 differentiated thyroid cancers, and we compared this with expression in 11 normal thyroids, 25 multinodular goiters, and 13 Graves; disease specimens. overexpression of PTTG and PBF in differentiated thyroid cancer has profound implications for activity of the NIS gene, and hence significantly impacts upon the efficacy of radioiodine treatment | Human | WNT5A | 7474 | wingless-type MMTV integration site family, member 5A | Wnt-5a serves as an antagonist to the canonical Wnt-signaling pathway with tumor suppressor activity in differentiated thyroid carcinomas Immunohistochemically, a bell-shaped response was observed with low to undetectable levels in normal tissue and in anaplastic tumors whereas differentiated thyroid carcinomas showed strong positive immunostaining for Wnt-5a. Our data are compatible with the hypothesis that Wnt-5a serves as an antagonist to the canonical Wnt-signaling pathway with tumor suppressor activity in differentiated thyroid carcinomas.Oncogene (2005) 24, 2144-2154. | Human | TPO | 7173 | thyroid peroxidase | Moreover, the value of TPO determination as a tool in the follow-up of differentiated thyroid carcinoma was not provable. Preliminary experience with determination of TPO in differentiated thyroid carcinomas. The research is based on previous reports that DPPIV/CD26 is overexpressed in differentiated thyroid carcinoma tissues, and that TPO activity is very low in thyroid carcinoma tissues. TPO mRNA expression in differentiated thyroid carcinomas did not always correlate with the mRNA expression of thyroglobulin, thyroid stimulating hormone receptor, and thyroid transcription factor 1. c-Kit proto-oncogene is more likely to lose expression in differentiated thyroid carcinoma than three thyroid-specific genes: thyroid peroxidase, thyroglobulin, and thyroid stimulating hormone receptor. Using non-quantitative reverse-transcription polymerase chain reaction (RT-PCR), we found that thyroid peroxidase (TPO) is expressed in all differentiated thyroid carcinomas examined, although the ratio of the shorter to longer transcript is decreased in tumors that had lost the iodide concentrating capacity. It is believed that qualitative changes in thyroid peroxidase (TPO) cause decreased enzyme activity in differentiated thyroid carcinoma. With various degrees of expression, all differentiated thyroid carcinomas (20 papillary and 2 follicular) expressed TSH-R, Tg, and TPO, but not CT mRNAs. Serum thyroperoxidase (TPO) and serum human thyroglobulin (hTg) were studied in 80 patients with differentiated thyroid carcinoma after thyroidectomy before and after the first therapeutic radioiodine application (;radioiodine thyroid ablation;) and, in some cases, after the second radioiodine application. Sequential changes in serum thyroid peroxidase following radioiodine therapy of patients with differentiated thyroid carcinoma. Thyroid peroxidase (TPO) as a tumor marker in the follow-up of differentiated thyroid carcinomas with surgical and ablative radioiodine therapy. To determine the detectability and the time course of serum thyroid peroxidase (TPO) levels before and 1, 2, 4, and 6 months after 131I administration, we evaluated TPO in 13 selected patients with differentiated thyroid carcinoma (DTC) whose sera did not contain antimicrosomal or antithyroglobulin (Tg) antibodies. We assessed the accuracy of real-time RT-PCR-based detection of a panel of thyroid-specific markers, including TG, TPO, TSHR, NIS and PDS, in comparison with serum TG measurements in a series of 55 patients operated for differentiated thyroid cancer (DTC). Thyroperoxidase: a tumor marker for post-therapeutic follow-up of differentiated thyroid carcinomas? [CD26/dipeptidyl peptidase IV and thyroid peroxidase as molecular markers for differentiated thyroid carcinoma] | Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | The high level of TNF alpha expression was noted both for typical and sought TNF R2/R7 isoforms and 3) A considerable number of samples displayed higher levels of TNF R2 isoforms than TNF R2/R7 mRNA expression in differentiated thyroid carcinomas | Human | TNF | 7124 | tumor necrosis factor | The presence of TNF alpha expression was observed in all examined samples of differentiated thyroid carcinomas in comparison to surrounding tissue free from neoplastic infiltration | Human | NKX2-1 | 7080 | | Nuclear localization of thyroid transcription factor-1 correlates with serum thyrotropin activity and may be increased in differentiated thyroid carcinomas with aggressive clinical course. TPO mRNA expression in differentiated thyroid carcinomas did not always correlate with the mRNA expression of thyroglobulin, thyroid stimulating hormone receptor, and thyroid transcription factor 1. | Human | THBS1 | 7057 | thrombospondin 1 | recent results dealing with regulation of TSP-1 expression by epidermal growth factor & hepatocyte growth factor; results show TSP-1 can have opposite effects on cell invasion depending upon type of differentiated thyroid carcinoma studied [review] | Human | TG | 7038 | thyroglobulin | expression level of thyroglobulin mRNA in the anaplastic thyroid carcinoma tissue and cell lines was <10(2) times higher than that in the differentiated thyroid carcinomas | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | Proteomic analysis of human thyroid cell lines reveals reduced nuclear localization of Mn-SOD in poorly differentiated thyroid cancer cells. | Human | SLC5A5 | 6528 | solute carrier family 5 (sodium/iodide cotransporter), member 5 | Molecular analysis of the expression of the sodium iodide symporter with differentiated thyroid cancer and correlation with scintigraphic findings | Human | RET | 5979 | ret proto-oncogene | study demonstrated RET amplification in all 3 cases of radiation-associated thyroid cancers(papillary thyroid cancer (PTC) & anaplastic thyroid cancer(ATC) but not in sporadic well-differentiated PTC; RET amplification was observed in all 6 cases of ATCs | Human | PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Mutant PIK3CA is likely to function as an oncogene in anaplastic thyroid cancer and less frequently well-differentiated thyroid carcinomas | Human | SLC26A4 | 5172 | solute carrier family 26 (anion exchanger), member 4 | PDS gene expression was not detected in 5 of 25 differentiated thyroid carcinomas (DTC) while NIS gene was not expressed in six carcinomas. CONCLUSIONS: Our data demonstrate that pendrin expression: (i) is present in the more differentiated thyroid carcinoma cell lines studied; (ii) is reduced or absent in DTC tissues; (iii) may not correlate with the NIS expression. We assessed the accuracy of real-time RT-PCR-based detection of a panel of thyroid-specific markers, including TG, TPO, TSHR, NIS and PDS, in comparison with serum TG measurements in a series of 55 patients operated for differentiated thyroid cancer (DTC). | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | Recombinant Human TSH Modulates In Vivo C-Telopeptides of Type-1 Collagen and Bone Alkaline Phosphatase, but Not Osteoprotegerin Production in Postmenopausal Women Monitored for Differentiated Thyroid Carcinoma. | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | For this purpose, thyroid resected specimens obtained from 94 differentiated thyroid carcinoma consecutive patients (64 papillary and 30 follicular) with at least 5 yr of follow-up were stained using monoclonal antibody to nm23-H1. We did not observe any relationship between nm23-H1 immunoreactivity and age, gender, initial differentiated thyroid carcinoma stage, local recurrence, or distant metastases in patients with papillary carcinoma. nm23-H1 immunoreactivity as a prognostic factor in differentiated thyroid carcinoma. Reduced nm23-H1 expression (a metastatic suppressor gene) has been correlated with high tumor metastatic potential in various human carcinomas, but the results obtained in differentiated thyroid carcinoma remain controversial. In stages I through III of differentiated thyroid carcinoma, the average level of Nm23 gene expression was comparable to that in multinodular goitres. To elucidate the usefulness of nm23-H1 as a differentiated thyroid carcinoma prognosis factor, we evaluate the relationship between nm23-H1 immunoreactivity as well as both clinical status and patient outcome. | Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Increased MMP-2 expression is associated with differentiated thyroid carcinoma | Human | MCM7 | 4176 | minichromosome maintenance complex component 7 | MCM7 mRNA expression is higher in locally invasive differentiated thyroid cancer. The level of MCM7 mRNA expression was higher in T4 than in T1, T2, and T3 differentiated thyroid cancers (P _lt_ 0.0127). | Human | KRT16 | 3868 | keratin 16 | K16 in turn was present only focally in well-developed squamous metaplasia in goitres but was not found in differentiated thyroid carcinomas. | Human | IGF1R | 3480 | insulin-like growth factor 1 receptor | Data show that differentiated thyroid cancers of children and adolescents express IGF-I and IGF-I receptors | Human | ID1 | 3397 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | In conclusion, Id1 is overexpressed in hyperplastic and neoplastic thyroid tissue and directly regulates the growth of thyroid cancer cells of follicular cell origin, but is not a marker of aggressive phenotype in differentiated thyroid cancer. Id1 is overexpressed in hyperplastic and neoplastic thyroid tissue and directly regulates the growth of thyroid cancer cells of follicular cell origin, but is not a marker of aggressive phenotype in differentiated thyroid cancer | Human | HLA-C | 3107 | | Frequency of HLA-C alleles in differentiated thyroid carcinoma in southeastern Spain. METHODS: HLA-C genotyping was performed in 63 patients undergoing surgery for differentiated thyroid carcinoma (57 patients with the papillary subtype and 6 patients with the follicular subtype). The aims of the current study were to determine whether there is a significant association between any HLA-C allele and differentiated thyroid carcinoma and to establish the possible susceptibility or protection alleles related to these tumors. a relation between HLA-Cw7 and differentiated thyroid carcinoma | Human | GRK5 | 2869 | G protein-coupled receptor kinase 5 | GRK5 protein expression was significantly decreased in differentiated thyroid carcinoma (P < 0.02) and paralleled a decrease in GRK mRNA expression (P < 0.02). Furthermore, the decrease in GRK5 expression may underlie the reduction in homologous desensitization of the TSH receptor in differentiated thyroid carcinoma, contributing to explain the increased cAMP levels in these tumors. | Human | FGF2 | 2247 | fibroblast growth factor 2 (basic) | pituitary tumor transforming gene and fibroblast growth factor-2 expression are potential prognostic markers (and perhaps therapeutic targets) for differentiated thyroid cancer | Human | ETS1 | 2113 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | CONCLUSIONS: Upregulation of ets-1 and downregulation of Tg mRNA expression occur in differentiated thyroid cancer and may facilitate pre-operative identification of thyroid malignancy depending on further evaluation of these potentially promising markers in a larger series of benign and malignant thyroid tumours and their FNAC samples. | Human | ERBB3 | 2065 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | Her3 showed significantly increased expression in differentiated thyroid cancer and correlated with lymph node metastasis,tumor type,and higher N stage |
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