Genes (85)
Species: human : 85 | |
Human | SPANXB1 | 728695 | SPANX family, member B1 | Expression of SpanX proteins in normal testes and in testicular germ cell tumours. Expression of SpanX mRNA in testicular germ cell tumors. A locus in Xq27, where the SpanX gene family is located, has been associated with testicular germ cell tumor (TGCT) onset. Summary We investigated the expression of the SpanX protein family in cells of normal testes and in testicular germ cell tumours, mainly seminomas and embryonal carcinomas, using an immunohistochemical approach. | Human | POU5F1P3 | 642559 | POU class 5 homeobox 1 pseudogene 3 | data suggest that loss of Oct-3/4 expression leads to induction of a higher apoptotic threshold and to cisplatin resistance in embryonal carcinoma cells of nonseminomatous testicular germ cell tumors | Human | ERVK7 | 449619 | | The technique was used to compare the expression of transcripts containing LTR (Long Terminal Repeat) sequences derived from human endogenous retrovirus K (HERV-K) in testicular germ cell tumors and in corresponding normal tissue. This prompted us to study ovarian and testicular germ cell tumors, their precursor lesions, dysgenetic gonads, and trophoblast lesions for expression of HERV-K sequences by in situ hybridization using radioactive and non-radioactive probes. Prompted by the observation of retroviral particle formation in teratocarcinoma cell lines and the consistent finding of antibodies against Gag and Env proteins encoded by human endogenous retrovirus (HERV)-K genomes in the sera of patients with classical seminoma, we studied ovarian and testicular germ cell tumours, their precursor lesions, dysgenetic gonads, and trophoblast lesions for expression of HERV-K sequences by in situ hybridization using radioactive and non-radioactive probes. Expression of the HERV-K human endogenous retrovirus is very low in normal and tumor tissue, but is readily detected in testicular germ cell tumors (TGCT). | Human | MIR373 | 442918 | microRNA 373 | miRNA-372 and miRNA-373 have roles as oncogenes in testicular germ cell tumors | Human | MIR372 | 442917 | microRNA 372 | miRNA-372 and miRNA-373 have roles as oncogenes in testicular germ cell tumors | Human | DPPA3 | 359787 | developmental pluripotency associated 3 | We have identified the human orthologue of DPPA3 and find by human EST analysis that it is expressed in human testicular germ cell tumours but not in normal human somatic tissues. | Human | NLRP7 | 199713 | NLR family, pyrin domain containing 7 | Transfection of small interfering RNA (siRNA) for NALP7 significantly reduced the NALP7 expression and resulted in growth suppression of testicular germ-cell tumors. | Human | INHBE | 83729 | inhibin, beta E | Human testicular germ cell tumours express inhibin subunits, activin receptors and follistatin mRNAs. | Human | NANOG | 79923 | Nanog homeobox | Our recent genome-wide gene expression profiling study of the precursor of testicular germ cell tumours, carcinoma in situ testis (CIS), showed close similarity between ESC and CIS, including high NANOG expression. | Human | BIRC7 | 79444 | baculoviral IAP repeat containing 7 | Livin is implicated in testicular tumorigenesis and to be related to the histological testicular germ cell tumors subtype | Human | ERVK6 | 64006 | | The technique was used to compare the expression of transcripts containing LTR (Long Terminal Repeat) sequences derived from human endogenous retrovirus K (HERV-K) in testicular germ cell tumors and in corresponding normal tissue. Expression of the HERV-K human endogenous retrovirus is very low in normal and tumor tissue, but is readily detected in testicular germ cell tumors (TGCT). Prompted by the observation of retroviral particle formation in teratocarcinoma cell lines and the consistent finding of antibodies against Gag and Env proteins encoded by human endogenous retrovirus (HERV)-K genomes in the sera of patients with classical seminoma, we studied ovarian and testicular germ cell tumours, their precursor lesions, dysgenetic gonads, and trophoblast lesions for expression of HERV-K sequences by in situ hybridization using radioactive and non-radioactive probes. | Human | ERVK4 | 60359 | | Expression of the HERV-K human endogenous retrovirus is very low in normal and tumor tissue, but is readily detected in testicular germ cell tumors (TGCT). The technique was used to compare the expression of transcripts containing LTR (Long Terminal Repeat) sequences derived from human endogenous retrovirus K (HERV-K) in testicular germ cell tumors and in corresponding normal tissue. | Human | ERVK5 | 60358 | | Expression of the HERV-K human endogenous retrovirus is very low in normal and tumor tissue, but is readily detected in testicular germ cell tumors (TGCT). The technique was used to compare the expression of transcripts containing LTR (Long Terminal Repeat) sequences derived from human endogenous retrovirus K (HERV-K) in testicular germ cell tumors and in corresponding normal tissue. | Human | TGCT1 | 50830 | testicular germ cell tumor susceptibility 1 | PURPOSE: An overabundance of X chromosomes in testicular germ cell tumors and the identification of the candidate testicular germ cell tumor susceptibility gene TGCT1 on Xq27 highlight the potential involvement of X chromosomes in testicular germ cell tumor pathogenesis. | Human | KLK14 | 43847 | kallikrein-related peptidase 14 | In testicular germ cell tumors, some tissue kallikrein genes, including KLK5, KLK10, KLK13 and KLK14, were found to be significantly down-regulated. | Human | PRSS50 | 29122 | protease, serine, 50 | We also discovered that expression of TSP50 was largely downregulated in all testicular germ cell tumors examined by immunohistochemical analysis. | Human | KLK13 | 26085 | kallikrein-related peptidase 13 | In testicular germ cell tumors, some tissue kallikrein genes, including KLK5, KLK10, KLK13 and KLK14, were found to be significantly down-regulated. | Human | KLK5 | 25818 | kallikrein-related peptidase 5 | In testicular germ cell tumors, some tissue kallikrein genes, including KLK5, KLK10, KLK13 and KLK14, were found to be significantly down-regulated. | Human | CHEK2 | 11200 | checkpoint kinase 2 | Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours. | Human | PRSS21 | 10942 | protease, serine, 21 (testisin) | Using sequence analysis of bisulphite-treated genomic DNA, we find a strong relationship between hypermethylation of a 385 bp 5; CpG rich island of the Testisin gene, and silencing of the Testisin gene in a range of human tumour cell lines and in 100% (eight/eight) of testicular germ cell tumours. Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors. | Human | PNMA2 | 10687 | paraneoplastic Ma antigen 2 | Ma2 is an autoantigen previously identified in patients with germ cell tumours of the testis and paraneoplastic brain stem and limbic encephalitis. | Human | MVP | 9961 | major vault protein | CONCLUSION: Immunohistochemistry is a reliable method to evaluate LRP expression in testicular germ cell tumors. The aim of this study was to evaluate the expression of LRP in germ cell testicular tumors (GCT) and to determine the correlation between LRP expression and the clinical outcome of these tumors. This study was undertaken to investigate the expression and predictive value for outcome of multidrug resistance-associated (MDR) proteins P-glycoprotein (Pgp), MRP1, BCRP, and LRP, in advanced testicular germ-cell tumours (TGCT). Expression and prognostic value of the lung resistance-related protein (LRP) in germ cell testicular tumors. Our findings suggest that LRP has prognostic value in testicular germ cell tumors and can predict clinical outcome. | Human | MDC1 | 9656 | mediator of DNA-damage checkpoint 1 | Contrary to carcinomas, almost no activation or loss of MDC1 or 53BP1 were found among testicular germ-cell tumours (TGCTs), a tumour type with unique biology and exceptionally low incidence of p53 mutations | Human | PLAA | 9373 | phospholipase A2-activating protein | PATIENTS AND METHODS: A total of 673 serum samples from 116 patients with testicular germ cell tumours (78 seminomas and 38 non-seminomas) were analysed for several markers including PLAP, total alkaline phosphatase (AL-P), alpha fetoprotein (AFP), beta human chorionic gonadotrophin (HCG-B), and lactic dehydrogenase (LDH). | Human | PIWIL1 | 9271 | piwi-like RNA-mediated gene silencing 1 | hiwi maps to the long arm of chromosome 12, band 12q24.33, a genomic region that displays genetic linkage to the development of testicular germ cell tumors of adolescents and adults (TGCTs), i.e., seminomas and nonseminomas. |
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