Human | SFTPA1 | 653509 | surfactant protein A1 | In these cases, the expression of Surfactant-apoprotein-A (SP-A) by the tumor cells has been a helpful feature in the process of diagnosis by indicating primary carcinomas of the lungs. |
Human | HIST4H4 | 121504 | histone cluster 4, H4 | Quantitative real-time RT-PCR analysis showed that Mth1 mRNA expression was slightly, but significantly, increased in the primary carcinomas (P = 0.001 using GAPDH for normalization, and P = 0.002 using histone H4, t-test), contrary to our expectation, and was decreased to 1 / 2 in the cell lines. |
Human | ANKRD30A | 91074 | ankyrin repeat domain 30A | NY-BR-1 expression was more frequent in estrogen receptor-positive and lymph node-negative primary carcinomas (P _lt_ 0.05 each) and was more common in grade 1 (77%) than in grade 2 (63%) or grade 3 (50%) carcinomas (P _lt_ 0.05). |
Human | HACE1 | 57531 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Aberrant methylation of the HACE1 gene was detected in 9 out of the 32 (28%) primary colon carcinomas |
Human | DIABLO | 56616 | diablo, IAP-binding mitochondrial protein | Whereas Smac/DIABLO and HtrA2 transcripts were normally expressed in all cancer specimens we examined, XAF1 transcript was not expressed or present at extremely low levels in 40% (6 of 15) of cancer cell lines and in 23% (20 of 87) of primary carcinomas. |
Human | XAF1 | 54739 | XIAP associated factor 1 | Whereas Smac/DIABLO and HtrA2 transcripts were normally expressed in all cancer specimens we examined, XAF1 transcript was not expressed or present at extremely low levels in 40% (6 of 15) of cancer cell lines and in 23% (20 of 87) of primary carcinomas. |
Human | DCUN1D1 | 54165 | DCN1, defective in cullin neddylation 1, domain containing 1 | Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors |
Human | PLUNC | 51297 | | PLUNC is a novel marker that distinguishes gastric hepatoid adenocarcinoma from primary hepatocellular carcinoma |
Human | HTRA2 | 27429 | HtrA serine peptidase 2 | Whereas Smac/DIABLO and HtrA2 transcripts were normally expressed in all cancer specimens we examined, XAF1 transcript was not expressed or present at extremely low levels in 40% (6 of 15) of cancer cell lines and in 23% (20 of 87) of primary carcinomas. |
Human | PDCD4 | 27250 | programmed cell death 4 (neoplastic transformation inhibitor) | Immunohistochemical analysis of 124 primary carcinomas comprising all subtypes demonstrated that PDCD4 protein expression was widely lost in tumour samples (83%) and was negatively related to poor prognosis (p = 0.013). |
Human | NUPR1 | 26471 | nuclear protein, transcriptional regulator, 1 | In attempts to explore the biological role of com1 in clinical tumor growth and metastasis, expression of com1 mRNA in primary carcinomas from 81 breast cancer patients and 27 samples of uninvolved adjacent breast tissue from these patients was compared and related to known prognostic parameters and outcome. |
Human | AKT3 | 10000 | v-akt murine thymoma viral oncogene homolog 3 | STK1 and STK2 display a variable pattern of expression among a series of primary carcinomas as well as cancer cell lines. |
Human | PTTG1 | 9232 | pituitary tumor-transforming 1 | PTTG1 expression is enhanced in metastatic lymph nodes in comparison to that in primary carcinomas and may contribute to lymph node metastases in gastric carcinoma CONCLUSION: The results of this study demonstrate that PTTG1 expression is enhanced in metastatic lymph nodes in comparison to that in primary carcinomas. |
Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | The mean survival of patients who had primary hepatocellular carcinoma with high RCAS1 protein expression was significantly longer than that of patients with low expression |
Human | CLDN10 | 9071 | claudin 10 | High Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma |
Human | SQSTM1 | 8878 | sequestosome 1 | p62 expression in primary carcinomas of the digestive system. AIM: To characterize p62 expression and define the relationship between p62 expression and cell proliferation in primary carcinomas of the digestive system. p62 expression in primary carcinomas of the gastrointestinal tract (60/60,100%) was higher than that (27/40, 67.5%) of HCC (P<0.01, chi(2) = 19.63). |
Human | SOCS2 | 8835 | suppressor of cytokine signaling 2 | Favorable prognostic value of high SOCS2 expression in primary mammary carcinomas |
Human | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | Analysis of surgical biopsy specimens showed the expression of RANKL (31%), RANK (38%), and OPG (19%) in primary carcinoma. |
Human | ARID1A | 8289 | AT rich interactive domain 1A (SWI-like) | in the primary breast carcinoma, transforming ARID1A sequence was an antisense cDNA, and was the product of a genomic rearrangement; identified a lung adenocarcinoma cell line with a highly localized homozygous genomic deletion in the 5' end of ARID1A |
Human | ZNF217 | 7764 | zinc finger protein 217 | CCND1 amplifications were associated with the pharyngeal site in primary carcinomas (P < 0.001), whereas amplifications of ZNF217 were less frequent in pharyngeal carcinomas as compared with primary oral and laryngeal carcinomas (P = 0.02). |
Human | TXN | 7295 | thioredoxin | To determine the intratumor distribution and amount of thioredoxin protein in human primary carcinomas, we developed an immunohistochemical assay for thioredoxin in paraffin-embedded tissue. |
Human | TPO | 7173 | thyroid peroxidase | Sequential tissue sections from glands affected by Graves; disease (n = 15), multinodular goitre (MNG, n = 26), benign nodules (n = 11), primary carcinomas (n = 12) and control thyroid glands (n = 5) were stained for ICAM-1, HLA class I, HLA class II, CD3 and thyroid peroxidase (TPO). |
Human | TP53 | 7157 | tumor protein p53 | p53 genetic alterations found in gastric stump carcinomas & intestinal-type primary gastric carcinomas could originate from a similar pathway; no association found between p53 gene status & P-gp expression |
Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | In attempts to elucidate which of these functions may prevail in breast cancer, expression of mRNAs for TIMP-1 and TIMP-2 in the primary carcinomas from 34 breast cancer patients was related to known prognostic parameters and the clinical outcome. The present data suggest that high levels of TIMP-1 and TIMP-2 mRNAs in the primary carcinomas are strongly associated with development of metastasis in breast cancer. |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | In attempts to elucidate which of these functions may prevail in breast cancer, expression of mRNAs for TIMP-1 and TIMP-2 in the primary carcinomas from 34 breast cancer patients was related to known prognostic parameters and the clinical outcome. The present data suggest that high levels of TIMP-1 and TIMP-2 mRNAs in the primary carcinomas are strongly associated with development of metastasis in breast cancer. |