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Details
Link-It Detail - Disease - Castleman's disease, multicentric
Debug Stats
  • ### Total Build Time: 28 ms 5.250 KB
  • CONCEPT_NAME gt=6 ms Completed: 6 ms rowSize= 364 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 931 bytes
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  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
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  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
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  • CONCEPT_RELATIONSHIPS gt=4 ms Completed: 4 ms rowSize= 106 bytes
  • CONCEPT_GENES gt=10 ms Completed: 10 ms rowSize= 2.645 KB
  • CONCEPT_XREFS gt=7 ms Completed: 7 ms rowSize= 1.167 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
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Disease (1)
Castleman's disease, multicentric C1334815
Definition (1)
A form of angiofollicular lymphoid hyperplasia characterized by fever, generalized lymphadenopathy, hypergammaglobulinemia, and dysfunction of multiple organs. Other signs and symptoms include anemia, thrombocytopenia, hepatomegaly, peripheral neuropathy and pleural effusions. Morphologically, in the majority of cases the lymph nodes show features of angiofollicular lymphoid hyperplasia of the plasma cell type. In a minority of cases, changes of angiofollicular lymphoid hyperplasia of the hyaline-vascular type are seen. In contrast to patients with localized disease who are usually cured following resection of the lesion, patients with the multicentric form of the disease may follow a progressive clinical course, complicated by infection, Kaposi sarcoma, or lymphoma.
Genes (2)

Species:
human : 2
SpeciesGeneGeneIdGene NameEvidence
HumanTLR47099toll-like receptor 4
img GENERIF, Score=1000, Pubmed Id: 18996347, UMLKSK CUI: C1334815
HumanMS4A1931membrane-spanning 4-domains, subfamily A, member 1
img NCI, Score=801, Pubmed Id: 15090823, UMLKSK CUI: C1334815
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1334815Castleman's disease, multicentric0self