GATACA

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Data

Data - ToppGene Sources

The vast majority of all data in Gataca is from ToppGene so its credits cover data sources that are used within Gataca. The primary reason for utilizing the same sources between these applications is to help ensure consistancy between them. ToppGene, and Gataca, uses data from over 20 sources.

For ToppGene Credits, please visit:

ToppGene Links (Credits)

Data - GUDMAP

GUDMAP

The GUDMAP data within Gataca is only availble within the GUDMAP interface:

Gataca's GUDMAP

Data - UMLSKS

UMLSKS website

Software

Software - Solr

Solr website

Software - PrototypeJS

Prototype JS website

Prototype JavaScript framework, version 1.7
(c) 2005-2010 Sam Stephenson
 
Prototype is freely distributable under the terms of an MIT-style license.
For details, see the Prototype web site: http://www.prototypejs.org/

Software - script.aculo.us

Script.aculo.us website

NOTE: Only the effects.js and dragdrop.js modules from Script.aculo.us are being used.

// script.aculo.us scriptaculous.js v1.9.0, Thu Dec 23 16:54:48 -0500 2010

// Copyright (c) 2005-2010 Thomas Fuchs (http://script.aculo.us, http://mir.aculo.us)
//
// Permission is hereby granted, free of charge, to any person obtaining
// a copy of this software and associated documentation files (the
// "Software"), to deal in the Software without restriction, including
// without limitation the rights to use, copy, modify, merge, publish,
// distribute, sublicense, and/or sell copies of the Software, and to
// permit persons to whom the Software is furnished to do so, subject to
// the following conditions:
//
// The above copyright notice and this permission notice shall be
// included in all copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
// EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
// MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
// NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE
// LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
// OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION
// WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
//
// For details, see the script.aculo.us web site: http://script.aculo.us/

Software - canvasXpress

canvasXpress website

CanvasXpress is a javascript library based on the <canvas> tag implemented in HTML5.

This package is currently being used for the Venn Diagram within SetBuilder. Plans are to utilize it in other areas in the generation of other graphs.

Software - Oracle Enterprise Edition

Oracle website

The data within Gataca is being stored in an Oracle 11g database.

Software - Modernizr

modernizr

modernizr provides simple interfacing to check to see what features are available within the client's browser. This is predomantly used to test for HTML 5 features such as canvas or local storage support.

Software - JQTouch

JQTouch website

JQTouch is being used for the mobile edition of Gataca.

Software - jQuery

JQuery website

jQuery is used within JQTouch only.

Software - tablesort

tablesort website

Copyright (c) 2006 Andrew Tetlaw 
http://tetlaw.id.au/view/blog/table-sorting-with-prototype/

Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use, copy,
modify, merge, publish, distribute, sublicense, and/or sell copies
of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.

Software - Firebug Light

Firebug Light website

firebugx.js - There is no disclaimer in the original file, but it is an open source project. The main website is http://www.getfirebug.com It is an open source project hosted by Google code.

Link-It Detail - Disease - Megakaryocytic Neoplasm

Debug Stats

### Total Build Time: 17 ms 61.301 KB
CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 344 bytes
CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
Skipping details on: CONCEPT_DEFINITION gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
CONCEPT_RELATIONSHIPS gt=2 ms Completed: 2 ms rowSize= 7.847 KB
CONCEPT_GENES gt=13 ms Completed: 13 ms rowSize= 51.891 KB
CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.157 KB
CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
Reload Stats

Disease (1)

Megakaryocytic Neoplasm C1334687

Relationships (14)

Relation Types:

diso_to_anat : 11

diso_to_diso : 3

Relationships:

is_abnormal_cell_of_disease : 4

is_associated_anatomic_site_of : 1

is_normal_cell_origin_of_disease : 2

is_normal_tissue_origin_of_disease : 2

is_not_abnormal_cell_of_disease : 1

is_primary_anatomic_site_of_disease : 1

isa : 2

may_be_finding_of_disease : 1

Relation Type	Co-Occuring Concept Count	Relationship	Concept
DISO_to_ANAT		is_primary_anatomic_site_of_disease	Bone Marrow C0005953
DISO_to_ANAT		is_normal_cell_origin_of_disease	Bone Marrow Stem Cell C1511246
DISO_to_ANAT		is_abnormal_cell_of_disease	Cancer Cell C0334227
DISO_to_ANAT		is_normal_tissue_origin_of_disease	HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANAT		is_normal_tissue_origin_of_disease	Haematopoietic tissue C0229619
DISO_to_ANAT		is_associated_anatomic_site_of	Hematopoietic and Lymphatic System C1512394
DISO_to_ANAT		is_normal_cell_origin_of_disease	Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANAT		is_abnormal_cell_of_disease	Neoplastic Cell C0597032
DISO_to_ANAT		is_not_abnormal_cell_of_disease	Neoplastic Erythroblast C1711389
DISO_to_ANAT		is_abnormal_cell_of_disease	Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANAT		is_abnormal_cell_of_disease	Neoplastic Myeloid Cell C1514039
DISO_to_DISO		isa	Acute Megakaryocytic Leukemias C0023462
DISO_to_DISO		isa	ESSENTIAL THROMBOCYTHEMIA C0040028
DISO_to_DISO		may_be_finding_of_disease	Hypercellular bone marrow C1334068

Genes (35)

Species:

human : 34

mouse : 1

Page Size

Current 25

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Current 1

Species	Gene	GeneId	Gene Name	Evidence
Mouse	MPL	4352	myeloproliferative leukemia virus oncogene	NCI, Score=801, Pubmed Id: 15234571, UMLKSK CUI: C1334687 We examined the effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on the development of L-8057, a murine megakaryoblastic leukemia that expresses the thrombopoietin receptor c-Mpl, in mice.
Human	PPBPL1	728045		NCI, Score=801, Pubmed Id: 6184272, UMLKSK CUI: C1334687 The use of anti beta-thromboglobulin serum for the diagnosis of megakaryoblastic leukaemia.
Human	SCIN	85477	scinderin	NCI, Score=801, Pubmed Id: 11568009, UMLKSK CUI: C1334687 The lack of scinderin expression in megakaryoblastic leukemia cells seems to be responsible for their inability to enter into differentiation and maturation pathways characteristic of their normal counterparts. NCI, Score=801, Pubmed Id: 11568009, UMLKSK CUI: C1334687 Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis.
Human	TUBA1C	84790	tubulin, alpha 1c	NCI, Score=801, Pubmed Id: 10942579, UMLKSK CUI: C1334687 In actinomycin D (AD)-induced apoptosis, caspase-3 activation and DNA cleavage in human megakaryoblastic leukemia CMK-7 cells were greatly accelerated by tubulin and actin polymerization inhibitors [e.g., colcemid (CL) and cytochalasin D (CD), respectively], but the acceleration was not found with Taxol or phalloidin.
Human	MKL1	57591	megakaryoblastic leukemia (translocation) 1	NCI, Score=801, Pubmed Id: 16098147, UMLKSK CUI: C1334687 Megakaryoblastic leukemia 1 (MKL1) was originally identified as a gene translocated in megakaryoblastic leukemia. NCI, Score=801, Pubmed Id: 15920491, UMLKSK CUI: C1334687 RBM15 and MKL1 mutational screening in megakaryoblastic leukemia cell lines and clinical samples. NCI, Score=801, Pubmed Id: 14970199, UMLKSK CUI: C1334687 In this report, we describe the capacity of myocardin to physically associate with megakaryoblastic leukemia factor-1 (MKL1) and characterize the function of MKL1 in smooth muscle cells (SMCs).
Human	PRAME	23532	preferentially expressed antigen in melanoma	NCI, Score=801, Pubmed Id: 15180862, UMLKSK CUI: C1334687 Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down;s syndrome, revealing PRAME as a specific discriminating marker.
Human	GNLY	10578	granulysin	NCI, Score=801, Pubmed Id: 12145461, UMLKSK CUI: C1334687 In this study, we found that the megakaryoblastic leukemia cell line CMK, established from a patient with Downs syndrome, expressed granulysin mRNA. NCI, Score=801, Pubmed Id: 12145461, UMLKSK CUI: C1334687 Expression of granulysin mRNA in the human megakaryoblastic leukemia cell line CMK.
Human	SPHK1	8877	sphingosine kinase 1	NCI, Score=801, Pubmed Id: 14729073, UMLKSK CUI: C1334687 The prolonged treatment with phorbol 12-myristate 13-acetate (PMA) of a human megakaryoblastic leukemia cell line, MEG-O1, induced increase of sphingosine kinase (SPHK) enzyme activity and SPHK1 protein expression as well as SPHK1 message.
Human	CXCR4	7852	chemokine (C-X-C motif) receptor 4	NCI, Score=801, Pubmed Id: 9680341, UMLKSK CUI: C1334687 Using flow cytometry in combination with reverse transcriptase-polymerase chain reaction (RT-PCR), we observed that bone marrow CD34(+), CD61(+) cells, blood platelets, and megakaryocytic leukemia cell lines all expressed the CXCR4 receptor.
Human	STAT5B	6777	signal transducer and activator of transcription 5B	NCI, Score=801, Pubmed Id: 9111365, UMLKSK CUI: C1334687 Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5.
Human	STAT5A	6776	signal transducer and activator of transcription 5A	NCI, Score=801, Pubmed Id: 9111365, UMLKSK CUI: C1334687 Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5.
Human	RAP1A	5906	RAP1A, member of RAS oncogene family	NCI, Score=801, Pubmed Id: 1549353, UMLKSK CUI: C1334687 Induction of smg p21/rap1A p21/krev-1 p21 gene expression during phorbol ester-induced differentiation of a human megakaryocytic leukemia cell line.
Human	PTPN11	5781	protein tyrosine phosphatase, non-receptor type 11	NCI, Score=801, Pubmed Id: 15561678, UMLKSK CUI: C1334687 She provides an overview of leukemias that are common in pediatric malignancies but rarely observed in adults, including the TEL-AML1 (ETV6-RUNX1) fusion associated with pediatric B-cell ALL, the OTT-MAL fusion associated with infant megakaryoblastic leukemia, PTPN11 mutations in juvenile myelomonocytic leukemia, and MLL fusion genes in leukemogenesis, among others.
Human	PTGIR	5739	prostaglandin I2 (prostacyclin) receptor (IP)	NCI, Score=801, Pubmed Id: 7514139, UMLKSK CUI: C1334687 A functional cDNA for the human prostacyclin receptor was isolated from a cDNA library of CMK cells, a human megakaryocytic leukaemia cell line.
Human	SRGN	5552	serglycin	NCI, Score=801, Pubmed Id: 7613073, UMLKSK CUI: C1334687 Phosphorothioate oligonucleotides cause degradation of secretory but not intracellular serglycin proteoglycan core protein in a sequence-independent manner in human megakaryocytic tumor cells. NCI, Score=801, Pubmed Id: 7613073, UMLKSK CUI: C1334687 Human megakaryocytic tumor cell lines CHRF-288-11 and HEL (human erythroleukemia) were incubated with antisense phosphodiester (PDE) and phosphorothioate (PS) oligodeoxynucleotides directed against the first six codons of the human serglycin proteoglycan gene. NCI, Score=801, Pubmed Id: 11012225, UMLKSK CUI: C1334687 This paper reviews the current status of knowledge of the structure, function and metabolism of the serglycin proteoglycan in megakaryocytes and megakaryocytic tumor cells. NCI, Score=801, Pubmed Id: 7613073, UMLKSK CUI: C1334687 Thus treatment of megakaryocytic tumor cells with PS-ODNs appeared to cause a selective degradation of the serglycin core protein in a sequence-independent manner.
Human	PDGFB	5155	platelet-derived growth factor beta polypeptide	NCI, Score=801, Pubmed Id: 2955817, UMLKSK CUI: C1334687 The 25S c-sis mRNA was detected in a megakaryoblastic leukemia cell line established from this patient. NCI, Score=801, Pubmed Id: 2955817, UMLKSK CUI: C1334687 Although the level varied, the mRNA of the c-sis gene was detected in all megakaryoblastic leukemia cells obtained at different clinical stages.
Human	NME1	4830	NME/NM23 nucleoside diphosphate kinase 1	NCI, Score=801, Pubmed Id: 8058309, UMLKSK CUI: C1334687 The expression levels of nm23-H1 mRNA and the levels of protein during induced differentiation of human leukemia cell lines were analysed. mRNA levels of the megakaryoblastic leukemia line MEG-01, which were induced to differentiate into megakaryocyte by TPA, decreased rapidly from 2 days after the start of treatment and became almost undetectable at day 4.
Human	MPL	4352	myeloproliferative leukemia virus oncogene	NCI, Score=801, Pubmed Id: 15234571, UMLKSK CUI: C1334687 We examined the effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on the development of L-8057, a murine megakaryoblastic leukemia that expresses the thrombopoietin receptor c-Mpl, in mice.
Human	LYN	4067	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	NCI, Score=801, Pubmed Id: 7636265, UMLKSK CUI: C1334687 Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e). NCI, Score=801, Pubmed Id: 7636265, UMLKSK CUI: C1334687 The role of the lyn product (p53/p56lyn), a membrane-associated protein tyrosine kinase in the signaling pathway used by granulocyte macrophage-CSFR (GM-CSFR) was investigated by using the GM-CSF-dependent human megakaryoblastic leukemia cell line M-07e.
Human	ITGB3	3690	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	NCI, Score=801, Pubmed Id: 8819897, UMLKSK CUI: C1334687 Immunogold labeling for the GpIIIa platelet glycoprotein (CD61) was used in cases where the light microscopy of blood films revealed possible megakaryoblastic leukemia.
Human	ITGA2B	3674	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	NCI, Score=801, Pubmed Id: 8078188, UMLKSK CUI: C1334687 Nine patients with acute leukemia showing 10% or more positive blast cells with platelet peroxidase (PPO) or CD41b were diagnosed as megakaryoblastic leukemia. NCI, Score=801, Pubmed Id: 7564468, UMLKSK CUI: C1334687 Human megakaryoblastic leukaemia cell lines have common biological features, including high expression of the megakaryocytic specific antigen: CD41; high expression of the early myeloid antigens: CD34 and CD33; constitutive expression of interleukin-6 and platelet-derived growth factor; complex karyotype picture; expression of c-kit: the stem cell factor receptor; growth-dependency or -stimulation by stem cell factor, interleukin-3 and/or GM-CSF; megakaryoblastic differentiation by phorbol-myristate-acetate; and in vivo tumorigenicity in mice is associated with marked fibrosis. NCI, Score=801, Pubmed Id: 8750618, UMLKSK CUI: C1334687 Human megakaryoblastic leukemia cell lines have common biological features: high expression of the megakaryocytic specific antigen (CD41); high expression of early myeloid antigens (CD34, CD33 and CD13); constitutive expression of IL-6 and platelet-derived growth factor; a complex karyotype picture; expression of c-kit (the stem cell factor receptor); growth-dependency or -stimulation by IL-3 and/or GM-CSF; and in vivo tumorigenicity in mice associated with marked fibrosis.
Human	IL9	3578	interleukin 9	NCI, Score=801, Pubmed Id: 7756643, UMLKSK CUI: C1334687 Interleukin-9 (IL-9) is a T-cell-derived multifunctional cytokine that can stimulate the proliferation of a human megakaryocytic leukemia cell line, MO7E. NCI, Score=801, Pubmed Id: 1693525, UMLKSK CUI: C1334687 Although the M-O7E cell line was derived from a patient with megakaryoblastic leukemia, IL-9 has not proved to be a growth or maturation factor for megakaryocytes, but instead has proved to be effective in supporting the development of erythroid bursts (BFU-E) in cultures supplemented with erythropoietin. NCI, Score=801, Pubmed Id: 1680606, UMLKSK CUI: C1334687 Interleukin-9 (IL9) is a relatively new cytokine that supports the growth of helper T-cell clones, mast cells, and megakaryoblastic leukemia cells.
Human	IL3	3562	interleukin 3 (colony-stimulating factor, multiple)	NCI, Score=801, Pubmed Id: 8021297, UMLKSK CUI: C1334687 IL-3 and ribavirin induce high level expression of megakaryocytic markers and messages during long-term treatment of a megakaryocytic leukemia cell line. NCI, Score=801, Pubmed Id: 7819061, UMLKSK CUI: C1334687 However, it remains unknown whether leukaemic megakaryoblasts can produce IL-3 and whether IL-3 is involved in the pathological process of megakaryoblastic leukaemia. NCI, Score=801, Pubmed Id: 8704203, UMLKSK CUI: C1334687 Interleukin-3 (IL-3) is a potent stimulator of megakaryocyte proliferation, and autocrine production of IL-3 by megakaryocytic leukemia cell lines and bone marrow-derived megakaryocytes has recently been demonstrated. NCI, Score=801, Pubmed Id: 8423333, UMLKSK CUI: C1334687 The M-07e megakaryocytic leukemia cell line, which proliferates in response to IL-3 or GM-CSF, was used to determine whether these cytokines were present in fluids derived after Ag challenge in the cutaneous blister chamber model. NCI, Score=801, Pubmed Id: 2273055, UMLKSK CUI: C1334687 We have isolated a subline of the M-07 human megakaryoblastic leukemia cell line, designated M-07e, that requires either interleukin-3 (IL-3) or granulocyte macrophage colony-stimulating factor (GM-CSF) for growth, even in the presence of fetal calf serum. NCI, Score=801, Pubmed Id: 8142647, UMLKSK CUI: C1334687 We show here that IL-3 and GM-CSF induce MAPKAP kinase 2 activity in the human megakaryoblastic leukemia cell line MO7 and phosphorylate the human small heat shock protein Hsp 27 on serine residues in vitro. NCI, Score=801, Pubmed Id: 7819061, UMLKSK CUI: C1334687 These findings indicate that IL-3, as an autocrine growth factor, is involved in the growth of some megakaryocytic leukaemia cell lines. NCI, Score=801, Pubmed Id: 8750618, UMLKSK CUI: C1334687 Human megakaryoblastic leukemia cell lines have common biological features: high expression of the megakaryocytic specific antigen (CD41); high expression of early myeloid antigens (CD34, CD33 and CD13); constitutive expression of IL-6 and platelet-derived growth factor; a complex karyotype picture; expression of c-kit (the stem cell factor receptor); growth-dependency or -stimulation by IL-3 and/or GM-CSF; and in vivo tumorigenicity in mice associated with marked fibrosis. NCI, Score=801, Pubmed Id: 7593232, UMLKSK CUI: C1334687 IL-3 and ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line. NCI, Score=801, Pubmed Id: 8704203, UMLKSK CUI: C1334687 These studies show that the transcriptional regulation of IL-3 expression in megakaryocytic leukemia cell lines is similar, but not identical to normal human T cells. NCI, Score=801, Pubmed Id: 7593232, UMLKSK CUI: C1334687 Differentiation of the megakaryocytic leukemia cells, CMK, was induced by long-term (12 day) treatment with the combination of IL-3 and the nucleoside analogue ribavirin (RV), which reduces cellular GTP levels. NCI, Score=801, Pubmed Id: 7678880, UMLKSK CUI: C1334687 The M07e megakaryoblastic leukemia cell line is strictly dependent on either interleukin 3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF) for continuous growth. NCI, Score=801, Pubmed Id: 7532035, UMLKSK CUI: C1334687 The UT-7 cell line was established from a patient with megakaryoblastic leukemia, and its growth and survival are strictly dependent on interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), erythropoietin (Epo), or IL-6. NCI, Score=801, Pubmed Id: 1290964, UMLKSK CUI: C1334687 We examined the changes in mRNA expression of granulocyte macrophage colony-stimulating factor receptor beta-subunit (GM-CSFR beta-subunit), which was a common subunit of a high-affinity interleukin-3 receptor (IL-3R) and a high-affinity GM-CSFR, and interleukin-6 receptor (IL-6R) during megakaryocyte development in a human megakaryocytic leukemia cell line (CMK) which could proliferate and/or differentiate in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA), IL-3, GM-CSF, and IL-6.
Human	FGF1	2246	fibroblast growth factor 1 (acidic)	NCI, Score=801, Pubmed Id: 7488550, UMLKSK CUI: C1334687 A new fibroblast growth stimulating activity has been identified in the supernatant of the ELF-153 human megakaryoblastic leukaemia cell line that is independent of the percentage of fetal calf serum in NRK-49F fibroblast agar clonogenic assays and is not due to any of the known fibroblast growth stimulating humoral factors including PDGF, epithelial growth factor, TGF-alpha or beta, tumour necrosis factor-alpha, interleukin-1, 2, 4 or 6, FGF, fibronectin, PF-4 and factor VIII AG.
Human	ETS2	2114	v-ets avian erythroblastosis virus E26 oncogene homolog 2	NCI, Score=801, Pubmed Id: 16140924, UMLKSK CUI: C1334687 We propose that trisomy 21 facilitates the occurrence of megakaryoblastic leukemias through a shift toward the megakaryoblastic lineage caused by the excess expression of ERG, and possibly by other chromosome 21 genes, such as RUNX1 and ETS2, in hematopoietic progenitor cells, coupled with a differentiation arrest caused by the acquisition of mutations in GATA1.

XRefs (1)

XRef Types:

cui : 1

ToppGene Datasets:

none : 1

ToppGene Datasets	XRef Type	XRef Id	XRef	Values	Source	Top % Rank
	CUI	C1334687	Megakaryocytic Neoplasm	0		self

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